Human alpha spectrin II and the Fanconi anemia proteins FANCA and FANCC interact to form a nuclear complex
about
A new spectrin, beta IV, has a major truncated isoform that associates with promyelocytic leukemia protein nuclear bodies and the nuclear matrixSpectrin interacts with EVL (Enabled/vasodilator-stimulated phosphoprotein-like protein), a protein involved in actin polymerizationEmerin caps the pointed end of actin filaments: evidence for an actin cortical network at the nuclear inner membraneTyrosine phosphorylation regulates alpha II spectrin cleavage by calpainFanconi anaemiaHES1 is a novel interactor of the Fanconi anemia core complexFormation and repair of interstrand cross-links in DNAFunctional Significance of Nuclear α Spectrin.Fanconi anemia proteins localize to chromatin and the nuclear matrix in a DNA damage- and cell cycle-regulated manner.Brain proteins interacting with the tetramerization region of non-erythroid alpha spectrin.An emerin "proteome": purification of distinct emerin-containing complexes from HeLa cells suggests molecular basis for diverse roles including gene regulation, mRNA splicing, signaling, mechanosensing, and nuclear architecture.Knockdown of mu-calpain in Fanconi anemia, FA-A, cells by siRNA restores alphaII spectrin levels and corrects chromosomal instability and defective DNA interstrand cross-link repair.The Fanconi anemia protein, FANCG, binds to the ERCC1-XPF endonuclease via its tetratricopeptide repeats and the central domain of ERCC1.Caspase-2 short isoform interacts with membrane-associated cytoskeleton proteins to inhibit apoptosis.Cell organization, growth, and neural and cardiac development require αII-spectrin.Lipoxin A4 counterregulates GM-CSF signaling in eosinophilic granulocytesGene expression profiling of whole blood in ipilimumab-treated patients for identification of potential biomarkers of immune-related gastrointestinal adverse events.Non-erythroid alpha spectrin prevents telomere dysfunction after DNA interstrand cross-link damageHepatic stem cells and transforming growth factor β in hepatocellular carcinomaNuclear alpha spectrin: Critical roles in DNA interstrand cross-link repair and genomic stability.Actin dynamics and functions in the interphase nucleus: moving toward an understanding of nuclear polymeric actin.Maintenance of genome stability by Fanconi anemia proteins.Beyond lamins other structural components of the nucleoskeleton.Nuclear α Spectrin Differentially Affects Monoubiquitinated Versus Non-Ubiquitinated FANCD2 Function After DNA Interstrand Cross-Link Damage.Nuclear mechanical resilience but not stiffness is modulated by αII-spectrin.Knockdown of alphaII spectrin in normal human cells by siRNA leads to chromosomal instability and decreased DNA interstrand cross-link repair.Regulation of the Fanconi anemia group C protein through proteolytic modification.MicroRNA-128-3p regulates mitomycin C-induced DNA damage response in lung cancer cells through repressing SPTAN1AlphaII-spectrin is an in vitro target for caspase-2, and its cleavage is regulated by calmodulin binding.The cellular control enzyme polyADP ribosyl transferase is eliminated in cultured Fanconi anemia fibroblasts at confluency.Current and emerging therapeutic strategies for Fanconi anemia.Patterns of spectrin expression in B-cell lymphomas: loss of spectrin isoforms is associated with nodule-forming and germinal center-related lymphomas.Spectrin and its interacting partners in nuclear structure and function.Spectrin alpha is important for rear polarization of the microtubule organizing center during migration and spindle pole assembly during division of neointimal smooth muscle cells.
P2860
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P2860
Human alpha spectrin II and the Fanconi anemia proteins FANCA and FANCC interact to form a nuclear complex
description
1999 nî lūn-bûn
@nan
1999 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Human alpha spectrin II and th ...... ract to form a nuclear complex
@ast
Human alpha spectrin II and th ...... ract to form a nuclear complex
@en
Human alpha spectrin II and th ...... ract to form a nuclear complex
@nl
type
label
Human alpha spectrin II and th ...... ract to form a nuclear complex
@ast
Human alpha spectrin II and th ...... ract to form a nuclear complex
@en
Human alpha spectrin II and th ...... ract to form a nuclear complex
@nl
prefLabel
Human alpha spectrin II and th ...... ract to form a nuclear complex
@ast
Human alpha spectrin II and th ...... ract to form a nuclear complex
@en
Human alpha spectrin II and th ...... ract to form a nuclear complex
@nl
P2093
P2860
P356
P1476
Human alpha spectrin II and th ...... ract to form a nuclear complex
@en
P2093
L W McMahon
M W Lambert
P2860
P304
P356
10.1074/JBC.274.46.32904
P407
P577
1999-11-12T00:00:00Z