Inhibition of c-src transcription by mithramycin: structure-activity relationships of biosynthetically produced mithramycin analogues using the c-src promoter as target
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Crystal Structure of Baeyer−Villiger Monooxygenase MtmOIV, the Key Enzyme of the Mithramycin Biosynthetic Pathway,FOSL1 controls the assembly of endothelial cells into capillary tubes by direct repression of αv and β3 integrin transcriptionModulation of the activity of Sp transcription factors by mithramycin analogues as a new strategy for treatment of metastatic prostate cancerThe crucial role of divalent metal ions in the DNA-acting efficacy and inhibition of the transcription of dimeric chromomycin A3Sp1 expression regulates lung tumor progression.Combined treatment of pancreatic cancer with mithramycin A and tolfenamic acid promotes Sp1 degradation and synergistic antitumor activityCrystal structure of the [Mg2+-(chromomycin A3)2]-d(TTGGCCAA)2 complex reveals GGCC binding specificity of the drug dimer chelated by a metal ionInhibition of Sp1-dependent transcription and antitumor activity of the new aureolic acid analogues mithramycin SDK and SK in human ovarian cancer xenografts.Deoxysugar transfer during chromomycin A3 biosynthesis in Streptomyces griseus subsp. griseus: new derivatives with antitumor activity.Novel GC-rich DNA-binding compound produced by a genetically engineered mutant of the mithramycin producer Streptomyces argillaceus exhibits improved transcriptional repressor activity: implications for cancer therapy.Identification of a novel cell type-specific intronic enhancer of macrophage migration inhibitory factor (MIF) and its regulation by mithramycin."Function-first" lead discovery: mode of action profiling of natural product libraries using image-based screeningIdentification of an inhibitor of the EWS-FLI1 oncogenic transcription factor by high-throughput screening.Combining betulinic acid and mithramycin a effectively suppresses pancreatic cancer by inhibiting proliferation, invasion, and angiogenesisA novel mithramycin analogue with high antitumor activity and less toxicity generated by combinatorial biosynthesis.Mithramycin analogues generated by combinatorial biosynthesis show improved bioactivitySemi-synthetic mithramycin SA derivatives with improved anticancer activity.Generation of new derivatives of the antitumor antibiotic mithramycin by altering the glycosylation pattern through combinatorial biosynthesis.Specific protein 1 depletion attenuates glucose uptake and proliferation of human glioma cells by regulating GLUT3 expression.Mithramycin is a gene-selective Sp1 inhibitor that identifies a biological intersection between cancer and neurodegeneration.Studies on the synthesis of durhamycin A: stereoselective synthesis of a model aglycone.Natural glycoconjugates with antitumor activity.Inhibition of p53-mediated transcriptional responses by mithramycin A.Role of the acyl groups in carbohydrate chains in cytotoxic properties of olivomycin A.Premithramycinone G, an early shunt product of the mithramycin biosynthetic pathway accumulated upon inactivation of oxygenase MtmOIIMithramycin-loaded mPEG-PLGA nanoparticles exert potent antitumor efficacy against pancreatic carcinoma.Entropically-driven binding of mithramycin in the minor groove of C/G-rich DNA sequences.Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.Mithramycin A suppresses basal triple-negative breast cancer cell survival partially via down-regulating Krüppel-like factor 5 transcription by Sp1.Mithramycin A Alleviates Osteoarthritic Cartilage Destruction by Inhibiting HIF-2α Expression.
P2860
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P2860
Inhibition of c-src transcription by mithramycin: structure-activity relationships of biosynthetically produced mithramycin analogues using the c-src promoter as target
description
2003 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2003
@ast
im Juli 2003 veröffentlicher wissenschaftlicher Artikel
@de
scientific article (publication date: 15 July 2003)
@en
vedecký článok (publikovaný 2003/07/15)
@sk
vědecký článek publikovaný v roce 2003
@cs
wetenschappelijk artikel (gepubliceerd op 2003/07/15)
@nl
наукова стаття, опублікована в липні 2003
@uk
مقالة علمية (نشرت في 15-7-2003)
@ar
name
Inhibition of c-src transcript ...... g the c-src promoter as target
@ast
Inhibition of c-src transcript ...... g the c-src promoter as target
@en
Inhibition of c-src transcript ...... g the c-src promoter as target
@nl
type
label
Inhibition of c-src transcript ...... g the c-src promoter as target
@ast
Inhibition of c-src transcript ...... g the c-src promoter as target
@en
Inhibition of c-src transcript ...... g the c-src promoter as target
@nl
prefLabel
Inhibition of c-src transcript ...... g the c-src promoter as target
@ast
Inhibition of c-src transcript ...... g the c-src promoter as target
@en
Inhibition of c-src transcript ...... g the c-src promoter as target
@nl
P2093
P3181
P356
P1433
P1476
Inhibition of c-src transcript ...... g the c-src promoter as target
@en
P2093
Carlo V Catapano
Eileen M McGuffie
Giuseppina M Carbone
Hamid R Bahadori
Jürgen Rohr
Lily L Remsing
P304
P3181
P356
10.1021/BI034091Z
P407
P577
2003-07-15T00:00:00Z