Structure-function relationships in the interaction between the urokinase-type plasminogen activator and its receptor
about
PATE gene clusters code for multiple, secreted TFP/Ly-6/uPAR proteins that are expressed in reproductive and neuron-rich tissues and possess neuromodulatory activityCrystal structure of the human urokinase plasminogen activator receptor bound to an antagonist peptideStructural Basis for Recognition of Urokinase-type Plasminogen Activator by Plasminogen Activator Inhibitor-1Isothiocyanate-Functionalized Bifunctional Chelates and fac-[M(I)(CO)3](+) (M = Re, (99m)Tc) Complexes for Targeting uPAR in Prostate CancerGenomic organization, tissue distribution and functional characterization of the rat Pate gene cluster.Elevated urinary levels of urokinase-type plasminogen activator receptor (uPAR) in pancreatic ductal adenocarcinoma identify a clinically high-risk group.Plasmin cleaves the juxtamembrane domain and releases truncated species of the urokinase receptor (CD87) from human bronchial epithelial cells.Mapping of the vitronectin-binding site on the urokinase receptor: involvement of a coherent receptor interface consisting of residues from both domain I and the flanking interdomain linker region.Synthesis and characterization of an (111)In-labeled peptide for the in vivo localization of human cancers expressing the urokinase-type plasminogen activator receptor (uPAR)Development of Receptor Targeted Magnetic Iron Oxide Nanoparticles for Efficient Drug Delivery and Tumor Imaging.Anti-tumour/metastasis effects of the potassium-sparing diuretic amiloride: an orally active anti-cancer drug waiting for its call-of-duty?Serum-stable RNA aptamers to urokinase-type plasminogen activator blocking receptor binding.Utility of the plasma level of suPAR in monitoring risk of mortality during TB treatmentFirst (18)F-labeled ligand for PET imaging of uPAR: in vivo studies in human prostate cancer xenografts.Extracellular matrix-associated gene expression in adult sensory neuron populations cultured on a laminin substrate.Plasminogen activation independent of uPA and tPA maintains wound healing in gene-deficient mice.Epithelial progenitor 1, a novel factor associated with epithelial cell growth and differentiation.Members of the murine Pate family are predominantly expressed in the epididymis in a segment-specific fashion and regulated by androgens and other testicular factors.Expression of C4.4A, a structural uPAR homolog, reflects squamous epithelial differentiation in the adult mouse and during embryogenesisThe Pseudomonas aeruginosa LasB metalloproteinase regulates the human urokinase-type plasminogen activator receptor through domain-specific endoproteolysisStroma targeting nuclear imaging and radiopharmaceuticals.Sense p16 and antisense uPAR bicistronic construct inhibits angiogenesis and induces glioma cell death.A flexible multidomain structure drives the function of the urokinase-type plasminogen activator receptor (uPAR)The acidic domain of the endothelial membrane protein GPIHBP1 stabilizes lipoprotein lipase activity by preventing unfolding of its catalytic domain.Ligand-engaged urokinase-type plasminogen activator receptor and activation of the CD11b/CD18 integrin inhibit late events of HIV expression in monocytic cells.Therapeutic potential of siRNA-mediated targeting of urokinase plasminogen activator, its receptor, and matrix metalloproteinases.Genome-wide protein QTL mapping identifies human plasma kallikrein as a post-translational regulator of serum uPAR levels.Urokinase plasminogen activator system as a potential target for cancer therapy.Functional intersection of the kallikrein-related peptidases (KLKs) and thrombostasis axis.A novel tumor targeting drug carrier for optical imaging and therapySmall-molecule modulators of zymogen activation in the fibrinolytic and coagulation systems.Radiometallated peptides targeting guanylate cyclase C and the urokinase-type plasminogen activator receptor.Structure-driven design of radionuclide tracers for non-invasive imaging of uPAR and targeted radiotherapy. The tale of a synthetic peptide antagonist.uPAR peptide antagonist alters regulation of MAP kinases and Bcl-2 family members in favor of apoptosis in MDA-MB-231 cell lineOverexpression of the urokinase receptor mRNA splice variant uPAR-del4/5 affects tumor-associated processes of breast cancer cells in vitro and in vivo.A doxycycline-inducible urokinase receptor (uPAR) upregulates uPAR activities including resistance to anoikis in human prostate cancer cell lines.Elevated plasma urokinase receptor predicts low birth weight in maternal malaria.Functional relevance of urinary-type plasminogen activator receptor-alpha3beta1 integrin association in proteinase regulatory pathways.Cross-talk between fMLP and vitronectin receptors triggered by urokinase receptor-derived SRSRY peptide.Domain 2 of the urokinase receptor contains an integrin-interacting epitope with intrinsic signaling activity: generation of a new integrin inhibitor.
P2860
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P2860
Structure-function relationships in the interaction between the urokinase-type plasminogen activator and its receptor
description
2003 nî lūn-bûn
@nan
2003 թուականին հրատարակուած գիտական յօդուած
@hyw
2003 թվականին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Structure-function relationshi ...... gen activator and its receptor
@ast
Structure-function relationshi ...... gen activator and its receptor
@en
Structure-function relationshi ...... gen activator and its receptor
@nl
type
label
Structure-function relationshi ...... gen activator and its receptor
@ast
Structure-function relationshi ...... gen activator and its receptor
@en
Structure-function relationshi ...... gen activator and its receptor
@nl
prefLabel
Structure-function relationshi ...... gen activator and its receptor
@ast
Structure-function relationshi ...... gen activator and its receptor
@en
Structure-function relationshi ...... gen activator and its receptor
@nl
P356
P1476
Structure-function relationshi ...... gen activator and its receptor
@en
P304
P356
10.2174/1381612033454630
P407
P577
2003-01-01T00:00:00Z