A positive-feedback-based bistable 'memory module' that governs a cell fate decision
about
To lyse or not to lyse: transient-mediated stochastic fate determination in cells infected by bacteriophagesRobust network topologies for generating switch-like cellular responsesMathematical modeling identifies inhibitors of apoptosis as mediators of positive feedback and bistabilityLinking fast and slow positive feedback loops creates an optimal bistable switch in cell signalingComputational modelling of the receptor-tyrosine-kinase-activated MAPK pathwayATM-mediated stabilization of hMutL DNA mismatch repair proteins augments p53 activation during DNA damagePositive feedback of G1 cyclins ensures coherent cell cycle entryMAPK signaling in equations and embryosThe smallest chemical reaction system with bistabilityTweaking biological switches through a better understanding of bistability behaviorSystems biology: On the cell cycle and its switchesGene switching rate determines response to extrinsic perturbations in the self-activation transcriptional network motifAutogenous and nonautogenous control of response in a genetic networkUnderstanding bistability in complex enzyme-driven reaction networksThe stability of a stochastic CaMKII switch: dependence on the number of enzyme molecules and protein turnoverA steady state analysis indicates that negative feedback regulation of PTP1B by Akt elicits bistability in insulin-stimulated GLUT4 translocationModeling T cell antigen discrimination based on feedback control of digital ERK responsesMultistable and multistep dynamics in neutrophil differentiation.On Having No Head: Cognition throughout Biological SystemsControl theory meets synthetic biologyMolecular signaling network motifs provide a mechanistic basis for cellular threshold responsesRegulatory gene network circuits underlying T cell development from multipotent progenitorsSpatial and temporal organization of signaling pathwaysFeedback loops and reciprocal regulation: recurring motifs in the systems biology of the cell cycleT cell responses to antigen: hasty proposals resolved through long engagementsStochasticity and the molecular mechanisms of induced pluripotencyBistable cell fate specification as a result of stochastic fluctuations and collective spatial cell behaviourPositive feedback of NDT80 expression ensures irreversible meiotic commitment in budding yeastGene networks of fully connected triads with complete auto-activation enable multistability and stepwise stochastic transitionsEpigenetic and conventional regulation is distributed among activators of FLO11 allowing tuning of population-level heterogeneity in its expressionInterlinked dual-time feedback loops can enhance robustness to stochasticity and persistence of memoryCellular memory of acquired stress resistance in Saccharomyces cerevisiae.Rational design of memory in eukaryotic cellsAn excitable gene regulatory circuit induces transient cellular differentiationComputational investigations into the origins of short-term biochemical memory in T cell activationSwitches, excitable responses and oscillations in the Ring1B/Bmi1 ubiquitination systemCharacterizing multistationarity regimes in biochemical reaction networksRoles of protein ubiquitination and degradation kinetics in biological oscillationsCycles and the qualitative evolution of chemical systemsDesign principles of a genetic alarm clock
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P2860
A positive-feedback-based bistable 'memory module' that governs a cell fate decision
description
2003 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Nature
@fr
artículu científicu espublizáu en 2003
@ast
scientific article (publication date: 27 November 2003)
@en
vedecký článok (publikovaný 2003/11/27)
@sk
vědecký článek publikovaný v roce 2003
@cs
wetenschappelijk artikel (gepubliceerd op 2003/11/27)
@nl
наукова стаття, опублікована в листопаді 2003
@uk
مقالة علمية (نشرت في 27-11-2003)
@ar
name
A positive-feedback-based bistable 'memory module' that governs a cell fate decision
@ast
A positive-feedback-based bistable 'memory module' that governs a cell fate decision
@en
A positive-feedback-based bistable 'memory module' that governs a cell fate decision
@nl
type
label
A positive-feedback-based bistable 'memory module' that governs a cell fate decision
@ast
A positive-feedback-based bistable 'memory module' that governs a cell fate decision
@en
A positive-feedback-based bistable 'memory module' that governs a cell fate decision
@nl
prefLabel
A positive-feedback-based bistable 'memory module' that governs a cell fate decision
@ast
A positive-feedback-based bistable 'memory module' that governs a cell fate decision
@en
A positive-feedback-based bistable 'memory module' that governs a cell fate decision
@nl
P3181
P356
P1433
P1476
A positive-feedback-based bistable 'memory module' that governs a cell fate decision
@en
P2093
James E Ferrell
P2888
P3181
P356
10.1038/NATURE02089
P407
P577
2003-11-27T00:00:00Z
P5875
P6179
1026655503