Mutation of a dibasic amino acid motif within the C terminus of the P2X7 nucleotide receptor results in trafficking defects and impaired function
about
Molecular and functional properties of P2X receptors--recent progress and persisting challengesConserved ectodomain cysteines are essential for rat P2X7 receptor traffickingIdentification of a trafficking motif involved in the stabilization and polarization of P2X receptorsMolecular properties of P2X receptorsThe C-terminus of human nucleotide receptor P2X7 is critical for receptor oligomerization and N-linked glycosylationNucleotide receptor signaling in murine macrophages is linked to reactive oxygen species generationCloning and pharmacological characterization of the guinea pig P2X7 receptor orthologueCloning and pharmacological characterization of the dog P2X7 receptor.The delta e13 isoform of the calcitonin receptor forms a six-transmembrane domain receptor with dominant-negative effects on receptor surface expression and signaling.Activation of the transcription factor FosB/activating protein-1 (AP-1) is a prominent downstream signal of the extracellular nucleotide receptor P2RX7 in monocytic and osteoblastic cells.The second transmembrane domain of P2X7 contributes to dilated pore formationLipopolysaccharide inhibits the channel activity of the P2X7 receptor.Transcriptional control mechanisms associated with the nucleotide receptor P2X7, a critical regulator of immunologic, osteogenic, and neurologic functions.C-terminal motif prediction in eukaryotic proteomes using comparative genomics and statistical over-representation across protein familiesAssociation between P2X7 Receptor Polymorphisms and Bone Status in Mice.P2 receptors: intracellular signaling.A truncated P2X7 receptor variant (P2X7-j) endogenously expressed in cervical cancer cells antagonizes the full-length P2X7 receptor through hetero-oligomerizationEpidermal growth factor facilitates epinephrine inhibition of P2X7-receptor-mediated pore formation and apoptosis: a novel signaling network.The nucleotide receptor P2RX7 mediates ATP-induced CREB activation in human and murine monocytic cells.Interaction of P2 purinergic receptors with cellular macromolecules.Assembly and trafficking of P2X purinergic receptors (Review).Nucleotide receptor P2RX7 stimulation enhances LPS-induced interferon-β production in murine macrophagesCell signaling via the P2X(7) nucleotide receptor: linkage to ROS production, gene transcription, and receptor traffickingThe trafficking and targeting of P2X receptors.P2X7-mediated chemoprevention of epithelial cancers.C terminus of the P2X7 receptor: treasure hunting.Identification and characterization of a novel variant of the human P2X(7) receptor resulting in gain of function.P2X7 receptor-mediated apoptosis of human cervical epithelial cells.C-terminal calmodulin-binding motif differentially controls human and rat P2X7 receptor current facilitation.Contribution of the Juxtatransmembrane Intracellular Regions to the Time Course and Permeation of ATP-gated P2X7 Receptor Ion ChannelsDifferential requirement for P2X7R function in IL-17 dependent vs. IL-17 independent cellular immune responses.The P2X7 receptor forms a dye-permeable pore independent of its intracellular domain but dependent on membrane lipid composition.Residues 155 and 348 contribute to the determination of P2X7 receptor function via distinct mechanisms revealed by single-nucleotide polymorphisms.Large-conductance channel formation mediated by P2X7 receptor activation is regulated through distinct intracellular signaling pathways in peritoneal macrophages and 2BH4 cells.The P2X7 Receptor.
P2860
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P2860
Mutation of a dibasic amino acid motif within the C terminus of the P2X7 nucleotide receptor results in trafficking defects and impaired function
description
2003 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2003
@ast
im August 2003 veröffentlichter wissenschaftlicher Artikel
@de
scientific article (publication date: August 2003)
@en
vedecký článok (publikovaný 2003/08/01)
@sk
vědecký článek publikovaný v roce 2003
@cs
wetenschappelijk artikel (gepubliceerd op 2003/08/01)
@nl
наукова стаття, опублікована в серпні 2003
@uk
مقالة علمية (نشرت في أغسطس 2003)
@ar
name
Mutation of a dibasic amino ac ...... defects and impaired function
@ast
Mutation of a dibasic amino ac ...... defects and impaired function
@en
Mutation of a dibasic amino ac ...... defects and impaired function
@nl
type
label
Mutation of a dibasic amino ac ...... defects and impaired function
@ast
Mutation of a dibasic amino ac ...... defects and impaired function
@en
Mutation of a dibasic amino ac ...... defects and impaired function
@nl
prefLabel
Mutation of a dibasic amino ac ...... defects and impaired function
@ast
Mutation of a dibasic amino ac ...... defects and impaired function
@en
Mutation of a dibasic amino ac ...... defects and impaired function
@nl
P2093
P1476
Mutation of a dibasic amino ac ...... defects and impaired function
@en
P2093
George R Dubyak
Julie A Sommer
Jyoti W Watters
Karen Parker
Lalitha Gudipaty
Loren C Denlinger
Paul J Bertics
Philip L Fisette
Richard A Proctor
P304
P356
10.4049/JIMMUNOL.171.3.1304
P407
P577
2003-08-01T00:00:00Z