Gene expression changes presage neurodegeneration in a Drosophila model of Parkinson's disease - Test2 - elhamkhani - TriplyDB

Gene expression changes presage neurodegeneration in a Drosophila model of Parkinson's disease

Gene expression changes presage neurodegeneration in a Drosophila model of Parkinson's disease

http://www.wikidata.org/entity/Q28201316

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Molecular markers of early Parkinson's disease based on gene expression in blood Parkin counteracts symptoms in a Drosophila model of Parkinson's disease.Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo Acyl-CoA synthetase activity links wild-type but not mutant alpha-synuclein to brain arachidonate metabolism Whole transcriptome analysis of a reversible neurodegenerative process in Drosophila reveals potential neuroprotective genes.Alpha-synuclein redistributes to neuromelanin lipid in the substantia nigra early in Parkinson's disease.Isotopolog perturbation techniques for metabolic networks: metabolic recycling of nutritional glucose in Drosophila melanogaster Association of cytochrome b5 with ETR1 ethylene receptor signaling through RTE1 in Arabidopsis.The glycolytic enzyme, GPI, is a functionally conserved modifier of dopaminergic neurodegeneration in Parkinson's models.Orchestrated increase of dopamine and PARK mRNAs but not miR-133b in dopamine neurons in Parkinson's disease.Drosophila melanogaster in the study of human neurodegeneration.Parkin and alpha-synuclein: opponent actions in the pathogenesis of Parkinson's disease.Functional genomics in Drosophila models of human disease.SKN-1/Nrf2 inhibits dopamine neuron degeneration in a Caenorhabditis elegans model of methylmercury toxicity.α-Synuclein Transgenic Drosophila As a Model of Parkinson's Disease and Related Synucleinopathies.Drosophila models of neurodegenerative diseases.Neuropathology, biochemistry, and biophysics of alpha-synuclein aggregation.Bridging molecular genetics and biomarkers in lewy body and related disorders What we can learn from animal models about cerebral multi-morbidity.Transcriptional modulator H2A histone family, member Y (H2AFY) marks Huntington disease activity in man and mouse Genes and pathways affected by CAG-repeat RNA-based toxicity in Drosophila The pugilistDominant Mutation of Drosophila melanogaster: A Simple-Sequence Repeat Disorder Reveals Localized Transport in the Eye.Polyunsaturated fatty acids induce alpha-synuclein-related pathogenic changes in neuronal cells Altered gene expression profiles reveal similarities and differences between Parkinson disease and model systems.Identification of novel genes that modify phenotypes induced by Alzheimer's beta-amyloid overexpression in Drosophila Microarrays in Parkinson's disease: a systematic approach.Quantitative proteomics of a presymptomatic A53T alpha-synuclein Drosophila model of Parkinson disease.Protein expression in a Drosophila model of Parkinson's disease.Physiological and pathological role of alpha-synuclein in Parkinson's disease through iron mediated oxidative stress; the role of a putative iron-responsive element Recent advances in using Drosophila to model neurodegenerative diseases.Exploiting the potential of molecular profiling in Parkinson's disease: current practice and future probabilities.Understanding and treating neurodegeneration: insights from the flies.Pla2g6 Deficiency in Zebrafish Leads to Dopaminergic Cell Death, Axonal Degeneration, Increased β-Synuclein Expression, and Defects in Brain Functions and Pathways.The dietary supplementation of nordihydroguaiaretic acid (NDGA) delayed the loss of climbing ability in Drosophila model of Parkinson's disease.Amino acid sequence motifs and mechanistic features of the membrane translocation of alpha-synuclein.Drosophila melanogaster White Mutant w1118 Undergo Retinal Degeneration.Impaired Wnt signaling in dopamine containing neurons is associated with pathogenesis in a rotenone triggered Drosophila Parkinson's disease model.Genetic and genomic studies of Drosophila parkin mutants implicate oxidative stress and innate immune responses in pathogenesis.

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P2860

Gene expression changes presage neurodegeneration in a Drosophila model of Parkinson's disease

http://www.wikidata.org/entity/Q28201316

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2003年の論文

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Human Molecular Genetics

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Clemens R Scherzer

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Mel B Feany

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Roderick V Jensen

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10.1093/HMG/DDG265

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12915459

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Parkinson's disease