The 5-HT3 antagonist tropisetron (ICS 205-930) is a potent and selective alpha7 nicotinic receptor partial agonist
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A randomised, double-blind, placebo-controlled trial of tropisetron in patients with schizophreniaStructural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal α7 nicotinic acetylcholine receptorCreating an 7 Nicotinic Acetylcholine Recognition Domain from the Acetylcholine-binding Protein: CRYSTALLOGRAPHIC AND LIGAND SELECTIVITY ANALYSESMultiple pharmacophores for the selective activation of nicotinic alpha7-type acetylcholine receptorsNicotinic mechanisms in the treatment of psychotic disorders: a focus on the α7 nicotinic receptorOndansetron results in improved auditory gating in DBA/2 mice through a cholinergic mechanismTreating schizophrenia symptoms with an alpha7 nicotinic agonist, from mice to men.The multi-functional drug tropisetron binds APP and normalizes cognition in a murine Alzheimer's model.High throughput electrophysiology with Xenopus oocytesThe binding orientation of epibatidine at α7 nACh receptorsThe binding orientations of structurally-related ligands can differ; A cautionary noteDiscovery of benzamide analogues as a novel class of 5-HT₃ receptor agonists.Hippocampal deletion of BDNF gene attenuates gamma oscillations in area CA1 by up-regulating 5-HT3 receptorNeuronal nicotinic receptors as analgesic targets: it's a winding roadα7 Nicotinic Receptor Agonists: Potential Therapeutic Drugs for Treatment of Cognitive Impairments in Schizophrenia and Alzheimer's Disease.Preclinical characterization of A-582941: a novel alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties.Hypoxia switches episodic breathing to singlet breathing in red-eared slider turtles (Trachemys scripta) via a tropisetron-sensitive mechanismComparative pharmacology of rat and human alpha7 nAChR conducted with net charge analysis.Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in VenomsVUF10166, a novel compound with differing activities at 5-HT₃A and 5-HT₃AB receptors.The stimulating effects of ethanol on ventral tegmental area dopamine neurons projecting to the ventral pallidum and medial prefrontal cortex in female Wistar rats: regional difference and involvement of serotonin-3 receptors.The Novel, Nicotinic Alpha7 Receptor Partial Agonist, BMS-933043, Improves Cognition and Sensory Processing in Preclinical Models of Schizophrenia.Identification and in vitro pharmacological characterization of a novel and selective α7 nicotinic acetylcholine receptor agonist, Br-IQ17B.Occupancy of α7 Nicotinic Acetylcholine Receptors in the Brain by Tropisetron: A Positron Emission Tomography Study Using [(11)C]CHIBA-1001 in Healthy Human SubjectsSelective breeding for high alcohol preference increases the sensitivity of the posterior VTA to the reinforcing effects of nicotine.Targeting of α7 Nicotinic Acetylcholine Receptors in the Treatment of Schizophrenia and the Use of Auditory Sensory Gating as a Translational BiomarkerThe structural basis of function in Cys-loop receptors.Spontaneous object recognition and its relevance to schizophrenia: a review of findings from pharmacological, genetic, lesion and developmental rodent models.Newer antipsychotics and upcoming molecules for schizophrenia.Biomedical importance of indoles.Pharmacotherapy of cognitive deficits in schizophrenia.From Chemotherapy-Induced Emesis to Neuroprotection: Therapeutic Opportunities for 5-HT3 Receptor Antagonists.Potential serotonergic agents for the treatment of schizophrenia.The development of novel polypharmacological agents targeting the multiple binding sites of nicotinic acetylcholine receptors.Tropisetron suppresses collagen synthesis in skin fibroblasts via α7 nicotinic acetylcholine receptor and attenuates fibrosis in a scleroderma mouse model.Tropisetron as a neuroprotective agent against glutamate-induced excitotoxicity and mechanisms of action.Tropisetron alleviate early post-operative pain after gynecological laparoscopy in sevoflurane based general anaesthesia: a randomized, parallel-group, factorial study.Quinuclidine compounds differently act as agonists of Kenyon cell nicotinic acetylcholine receptors and induced distinct effect on insect ganglionic depolarizations.The current agonists and positive allosteric modulators of α7 nAChR for CNS indications in clinical trials.Peripheral 5-HT3 Receptors Are Involved in the Antinociceptive Effect of Bunodosine 391.
P2860
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P2860
The 5-HT3 antagonist tropisetron (ICS 205-930) is a potent and selective alpha7 nicotinic receptor partial agonist
description
2001 nî lūn-bûn
@nan
2001 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
The 5-HT3 antagonist tropisetr ...... tinic receptor partial agonist
@ast
The 5-HT3 antagonist tropisetr ...... tinic receptor partial agonist
@en
The 5-HT3 antagonist tropisetr ...... tinic receptor partial agonist
@nl
type
label
The 5-HT3 antagonist tropisetr ...... tinic receptor partial agonist
@ast
The 5-HT3 antagonist tropisetr ...... tinic receptor partial agonist
@en
The 5-HT3 antagonist tropisetr ...... tinic receptor partial agonist
@nl
prefLabel
The 5-HT3 antagonist tropisetr ...... tinic receptor partial agonist
@ast
The 5-HT3 antagonist tropisetr ...... tinic receptor partial agonist
@en
The 5-HT3 antagonist tropisetr ...... tinic receptor partial agonist
@nl
P2093
P3181
P1476
The 5-HT3 antagonist tropisetr ...... tinic receptor partial agonist
@en
P2093
J C Gordon
T Lanthorn
P304
P3181
P356
10.1016/S0960-894X(00)00670-3
P407
P577
2001-02-12T00:00:00Z