Glucocorticoid signaling is perturbed by the atypical orphan receptor and corepressor SHP
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LXXLL motifs and AF-2 domain mediate SHP (NR0B2) homodimerization and DAX1 (NR0B1)-DAX1A heterodimerizationComplex Coordination of Cell Plasticity by a PGC-1α-controlled Transcriptional Network in Skeletal MuscleNuclear Receptors as Therapeutic Targets in Liver Disease: Are We There Yet?Role of nuclear receptor SHP in metabolism and cancer.Structural and biochemical basis for selective repression of the orphan nuclear receptor liver receptor homolog 1 by small heterodimer partner.Glucocorticoids promote structural and functional maturation of foetal cardiomyocytes: a role for PGC-1α.Hormone binding and co-regulator binding to the glucocorticoid receptor are allosterically coupled.PGC-1alpha negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erb(alpha) axis.Negative regulators of brown adipose tissue (BAT)-mediated thermogenesisAMPK-dependent repression of hepatic gluconeogenesis via disruption of CREB.CRTC2 complex by orphan nuclear receptor small heterodimer partner.Sodium arsenite induces orphan nuclear receptor SHP gene expression via AMP-activated protein kinase to inhibit gluconeogenic enzyme gene expression.Deciphering the nuclear bile acid receptor FXR paradigm.PGC-1 coactivators in the control of energy metabolism.Bile Acid signaling in liver metabolism and diseases.Metformin suppresses pregnane X receptor (PXR)-regulated transactivation of CYP3A4 geneCoordinated recruitment of histone methyltransferase G9a and other chromatin-modifying enzymes in SHP-mediated regulation of hepatic bile acid metabolism.A pleiotropic role for the orphan nuclear receptor small heterodimer partner in lipid homeostasis and metabolic pathways.Proteome-scale Binary Interactomics in Human Cells.Role of nuclear receptors in lipid dysfunction and obesity-related diseases.Nuclear bile acid receptor FXR as pharmacological target: are we there yet?Endoplasmic reticulum stress-induced activation of activating transcription factor 6 decreases insulin gene expression via up-regulation of orphan nuclear receptor small heterodimer partner.Pharmacology of bile acid receptors: Evolution of bile acids from simple detergents to complex signaling molecules.Expression and activation of the farnesoid X receptor in the vasculature.Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.The orphan nuclear receptor SHP inhibits apoptosis during the monocytic differentiation by inducing p21WAF1.Targeting orphan nuclear receptor SHP in the treatment of metabolic diseases.Lipid-sensing nuclear receptors in the pathophysiology and treatment of the metabolic syndrome.Functional crosstalk of PGC-1 coactivators and inflammation in skeletal muscle pathophysiology.Glucocorticoid hormones and energy homeostasis.Compound A influences gene regulation of the Dexamethasone-activated glucocorticoid receptor by alternative cofactor recruitment.Structural Analysis of the Glucocorticoid Receptor Ligand-Binding Domain in Complex with Triamcinolone Acetonide and a Fragment of the Atypical Coregulator, Small Heterodimer Partner.Stabilization of small heterodimer partner mRNA by grape seed procyanidins extract in cultured hepatocytes.Role of an mSin3A-Swi/Snf chromatin remodeling complex in the feedback repression of bile acid biosynthesis by SHP.Transcriptional repression of the gluconeogenic gene PEPCK by the orphan nuclear receptor SHP through inhibitory interaction with C/EBPalpha.Differential regulation of human and mouse orphan nuclear receptor small heterodimer partner promoter by sterol regulatory element binding protein-1.Bile acids regulate gluconeogenic gene expression via small heterodimer partner-mediated repression of hepatocyte nuclear factor 4 and Foxo1.The nuclear bile acid receptor FXR is activated by PGC-1alpha in a ligand-dependent manner.An adamantyl-substituted retinoid-derived molecule that inhibits cancer cell growth and angiogenesis by inducing apoptosis and binds to small heterodimer partner nuclear receptor: effects of modifying its carboxylate group on apoptosis, proliferatioInsights into the binding mode and mechanism of action of some atypical retinoids as ligands of the small heterodimer partner (SHP).Txnip contributes to impaired glucose tolerance by upregulating the expression of genes involved in hepatic gluconeogenesis in mice.
P2860
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P2860
Glucocorticoid signaling is perturbed by the atypical orphan receptor and corepressor SHP
description
2002 nî lūn-bûn
@nan
2002 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Glucocorticoid signaling is perturbed by the atypical orphan receptor and corepressor SHP
@ast
Glucocorticoid signaling is perturbed by the atypical orphan receptor and corepressor SHP
@en
Glucocorticoid signaling is perturbed by the atypical orphan receptor and corepressor SHP
@nl
type
label
Glucocorticoid signaling is perturbed by the atypical orphan receptor and corepressor SHP
@ast
Glucocorticoid signaling is perturbed by the atypical orphan receptor and corepressor SHP
@en
Glucocorticoid signaling is perturbed by the atypical orphan receptor and corepressor SHP
@nl
prefLabel
Glucocorticoid signaling is perturbed by the atypical orphan receptor and corepressor SHP
@ast
Glucocorticoid signaling is perturbed by the atypical orphan receptor and corepressor SHP
@en
Glucocorticoid signaling is perturbed by the atypical orphan receptor and corepressor SHP
@nl
P2093
P2860
P356
P1476
Glucocorticoid signaling is perturbed by the atypical orphan receptor and corepressor SHP
@en
P2093
Eckardt Treuter
Knut R Steffensen
Lotta Johansson Borgius
P2860
P304
P356
10.1074/JBC.M205641200
P407
P577
2002-12-20T00:00:00Z