Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2 - Test2 - elhamkhani - TriplyDB

Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2

Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2

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Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity.FLASH links the CD95 signaling pathway to the cell nucleus and nuclear bodies Tumor necrosis factor alpha-induced desumoylation and cytoplasmic translocation of homeodomain-interacting protein kinase 1 are critical for apoptosis signal-regulating kinase 1-JNK/p38 activation The epigenetic regulator UHRF1 promotes ubiquitination-mediated degradation of the tumor-suppressor protein promyelocytic leukemia protein Dynamic regulation of p53 subnuclear localization and senescence by MORC3 Protein kinase C delta regulates Ser46 phosphorylation of p53 tumor suppressor in the apoptotic response to DNA damage Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation The WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functions Homeodomain-interacting protein kinase 2 plays an important role in normal terminal erythroid differentiation Possible role of death receptor-mediated apoptosis by the E3 ubiquitin ligases Siah2 and POSH Ubiquitination and degradation of homeodomain-interacting protein kinase 2 by WD40 repeat/SOCS box protein WSB-1 AXIN is an essential co-activator for the promyelocytic leukemia protein in p53 activation Protein interaction analysis of senataxin and the ALS4 L389S mutant yields insights into senataxin post-translational modification and uncovers mutant-specific binding with a brain cytoplasmic RNA-encoded peptide Myeloid Elf-1-like factor, an ETS transcription factor, up-regulates lysozyme transcription in epithelial cells through interaction with promyelocytic leukemia protein How cells switch HIPK2 on and off The human protein kinase HIPK2 phosphorylates and downregulates the methyl-binding transcription factor ZBTB4 US11 of herpes simplex virus type 1 interacts with HIPK2 and antagonizes HIPK2-induced cell growth arrest Involvement of the Hipk family in regulation of eyeball size, lens formation and retinal morphogenesis HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function Cyclic AMP stimulates SF-1-dependent CYP11A1 expression through homeodomain-interacting protein kinase 3-mediated Jun N-terminal kinase and c-Jun phosphorylation Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK Alterations in gene expression and sensitivity to genotoxic stress following HdmX or Hdm2 knockdown in human tumor cells harboring wild-type p53 The role of cullin 5-containing ubiquitin ligases The function, regulation and therapeutic implications of the tumor suppressor protein, PML Role of HIPK2 in kidney fibrosis The cell biology of disease: Acute promyelocytic leukemia, arsenic, and PML bodies HIPK2 is a new drug target for anti-fibrosis therapy in kidney disease Another fork in the road--life or death decisions by the tumour suppressor p53 An African-specific polymorphism in the TP53 gene impairs p53 tumor suppressor function in a mouse model Desumoylation of homeodomain-interacting protein kinase 2 (HIPK2) through the cytoplasmic-nuclear shuttling of the SUMO-specific protease SENP1.Homeodomain-Interacting Protein Kinase-2: A Critical Regulator of the DNA Damage Response and the Epigenome p53 Acetylation: Regulation and Consequences Targeting hypoxia in cancer cells by restoring homeodomain interacting protein-kinase 2 and p53 activity and suppressing HIF-1alpha Overlapping roles for homeodomain-interacting protein kinases hipk1 and hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals.Essential function of HIPK2 in TGFbeta-dependent survival of midbrain dopamine neurons Interaction of Brn3a and HIPK2 mediates transcriptional repression of sensory neuron survival Deficiency in the multicopy Sycp3-like X-linked genes Slx and Slxl1 causes major defects in spermatid differentiation Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation Phosphorylation and transactivation of Pax6 by homeodomain-interacting protein kinase 2 DYRK3 activation, engagement of protein kinase A/cAMP response element-binding protein, and modulation of progenitor cell survival

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Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2

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2002 nî lūn-bûn

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2002年の論文

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Regulation of p53 activity by ...... n-interacting protein kinase-2

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Nature Cell Biology

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Andreas Möller

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Hans Will

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Hüaeyin Sirma

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M Lienhard Schmitz

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Thomas G Hofmann

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Wulf Dröge

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Yoichi Taya

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P2860

PML regulates p53 acetylation and premature senescence induced by oncogenic Ras

p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

Regulation of p53 activity in nuclear bodies by a specific PML isoform

Mdm2 promotes the rapid degradation of p53

p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage

Mixed-lineage kinase 3 delivers CD3/CD28-derived signals into the IkappaB kinase complex

NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription

Modulation of CREB binding protein function by the promyelocytic (PML) oncoprotein suggests a role for nuclear bodies in hormone signaling

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

Regulation of p53 stability by Mdm2

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1-10

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2047311

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10.1038/NCB715

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1

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4

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Hanswalter Zentgraf

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2002-01-01T00:00:00Z

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11615198

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1007633392

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11740489

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