Chronic overexpression of the calcineurin inhibitory gene DSCR1 (Adapt78) is associated with Alzheimer's disease
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Mutational analyses of the signals involved in the subcellular location of DSCR1.Regulation of RCAN1 protein activity by Dyrk1A protein-mediated phosphorylationProtein phosphatases and Alzheimer's diseaseDissecting Alzheimer disease in Down syndrome using mouse modelsNebula/DSCR1 upregulation delays neurodegeneration and protects against APP-induced axonal transport defects by restoring calcineurin and GSK-3β signalingSynaptic Vesicle Recycling Is Unaffected in the Ts65Dn Mouse Model of Down SyndromeCalcineurin activity in children with Mental handicap.A calcineurin inhibitory protein overexpressed in Down's syndrome interacts with the product of a ubiquitously expressed transcript.NF-kappaB-inducing kinase phosphorylates and blocks the degradation of Down syndrome candidate region 1.Interleukin-11 in endometrial adenocarcinoma is regulated by prostaglandin F2alpha-F-prostanoid receptor interaction via the calcium-calcineurin-nuclear factor of activated T cells pathway and negatively regulated by the regulator of calcineurin-1.Role of protein phosphatases and mitochondria in the neuroprotective effects of estrogens.Neuropathological role of PI3K/Akt/mTOR axis in Down syndrome brain.Role of metal ions in the cognitive decline of Down syndrome.RCAN1 regulates mitochondrial function and increases susceptibility to oxidative stress in mammalian cells.Identification and dissection of Ca(2+)-binding sites in the extracellular domain of Ca(2+)-sensing receptor.Over-expression of RCAN1 causes Down syndrome-like hippocampal deficits that alter learning and memory.Calcineurin A versus NS5A-TP2/HD domain containing 2: a case study of site-directed low-frequency random mutagenesis for dissecting target specificity of peptide aptamersPituitary Adenylate Cyclase-activating Polypeptide (PACAP) Targets Down Syndrome Candidate Region 1 (DSCR1/RCAN1) to control Neuronal Differentiation.Expression level of sarah, a homolog of DSCR1, is critical for ovulation and female courtship behavior in Drosophila melanogasterRegulator of calcineurin 1 (RCAN1) facilitates neuronal apoptosis through caspase-3 activation.Rescue of calcineurin Aα(-/-) mice reveals a novel role for the α isoform in the salivary gland.Down syndrome--recent progress and future prospects.What Are the bona fide GSK3 Substrates?Isoform-specific dephosphorylation of dynamin1 by calcineurin couples neurotrophin receptor endocytosis to axonal growth.GSK-3 kinases enhance calcineurin signaling by phosphorylation of RCNsStructural basis for activation of calcineurin by calmodulinMechanism of Oxidative Stress and Synapse Dysfunction in the Pathogenesis of Alzheimer's Disease: Understanding the Therapeutics StrategiesThe use of mouse models for understanding the biology of down syndrome and agingChronic expression of RCAN1-1L protein induces mitochondrial autophagy and metabolic shift from oxidative phosphorylation to glycolysis in neuronal cells.Bidirectional Regulation of Amyloid Precursor Protein-Induced Memory Defects by Nebula/DSCR1: A Protein Upregulated in Alzheimer's Disease and Down SyndromeAltered gene expression profiles reveal similarities and differences between Parkinson disease and model systems.Over-expression of DSCR1 protects against post-ischemic neuronal injuryRCAN1 links impaired neurotrophin trafficking to aberrant development of the sympathetic nervous system in Down syndrome.Free radical biology and medicine: it's a gas, man!Creation and characterization of BAC-transgenic mice with physiological overexpression of epitope-tagged RCAN1 (DSCR1)A rare de novo duplication of chromosome 21q22.12 → q22.3 with other concomitant deletion and duplication of small fragments in 21q associated with Down syndrome: Prenatal diagnosis, molecular cytogenetic characterizationThe calcineurin inhibitor Sarah (Nebula) exacerbates Aβ42 phenotypes in a Drosophila model of Alzheimer's disease.The genomically mosaic brain: aneuploidy and more in neural diversity and disease.Calcium homeostasis and modulation of synaptic plasticity in the aged brain.Amyloid-β toxicity and tau hyperphosphorylation are linked via RCAN1 in Alzheimer's disease.
P2860
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P2860
Chronic overexpression of the calcineurin inhibitory gene DSCR1 (Adapt78) is associated with Alzheimer's disease
description
2001 nî lūn-bûn
@nan
2001 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Chronic overexpression of the ...... iated with Alzheimer's disease
@ast
Chronic overexpression of the ...... iated with Alzheimer's disease
@en
Chronic overexpression of the ...... iated with Alzheimer's disease
@nl
type
label
Chronic overexpression of the ...... iated with Alzheimer's disease
@ast
Chronic overexpression of the ...... iated with Alzheimer's disease
@en
Chronic overexpression of the ...... iated with Alzheimer's disease
@nl
prefLabel
Chronic overexpression of the ...... iated with Alzheimer's disease
@ast
Chronic overexpression of the ...... iated with Alzheimer's disease
@en
Chronic overexpression of the ...... iated with Alzheimer's disease
@nl
P356
P1476
Chronic overexpression of the ...... iated with Alzheimer's disease
@en
P2093
P304
38787-38794
P356
10.1074/JBC.M102829200
P407
P50
P577
2001-08-01T00:00:00Z