Biosynthetic processing of the pro-alpha 1(V)2pro-alpha 2(V) collagen heterotrimer by bone morphogenetic protein-1 and furin-like proprotein convertases
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GDF11 forms a bone morphogenetic protein 1-activated latent complex that can modulate nerve growth factor-induced differentiation of PC12 cellsOrder of intron removal influences multiple splice outcomes, including a two-exon skip, in a COL5A1 acceptor-site mutation that results in abnormal pro-alpha1(V) N-propeptides and Ehlers-Danlos syndrome type IFunctional genomic analysis of C. elegans moltingMammalian tolloid proteinases: role in growth factor signallingTransforming growth factor-beta induces secretion of activated ADAMTS-2. A procollagen III N-proteinase.Bone morphogenetic protein-1/Tolloid-like proteinases process dentin matrix protein-1Proteinases of the bone morphogenetic protein-1 family convert procollagen VII to mature anchoring fibril collagenPost-translational modification of bone morphogenetic protein-1 is required for secretion and stability of the proteinConstitutive release of alpha4 type V collagen N-terminal domain by Schwann cells and binding to cell surface and extracellular matrix heparan sulfate proteoglycansBMP-1-mediated proteolytic processing of alternatively spliced isoforms of collagen type XIBone morphogenetic protein 1 processes prolactin to a 17-kDa antiangiogenic factor.Collagen V-induced nasal tolerance downregulates pulmonary collagen mRNA gene and TGF-beta expression in experimental systemic sclerosis.Characterization of the six zebrafish clade B fibrillar procollagen genes, with evidence for evolutionarily conserved alternative splicing within the pro-alpha1(V) C-propeptide.A novel splice variant in the N-propeptide of COL5A1 causes an EDS phenotype with severe kyphoscoliosis and eye involvement.First evidence of bone morphogenetic protein 1 expression and activity in sheep ovarian follicles.The collagen V homotrimer [alpha1(V)](3) production is unexpectedly favored over the heterotrimer [alpha1(V)](2)alpha2(V) in recombinant expression systems.Interaction properties of the procollagen C-proteinase enhancer protein shed light on the mechanism of stimulation of BMP-1.Low resolution structure determination shows procollagen C-proteinase enhancer to be an elongated multidomain glycoprotein.Procollagen C proteinase enhancer 1 genes are important determinants of the mechanical properties and geometry of bone and the ultrastructure of connective tissues.Biosynthetic processing of the Pro-alpha1(V)Pro-alpha2(V)Pro-alpha3(V) procollagen heterotrimer.DSP-PP precursor protein cleavage by tolloid-related-1 protein and by bone morphogenetic protein-1Identification of the minimal domain structure of bone morphogenetic protein-1 (BMP-1) for chordinase activity: chordinase activity is not enhanced by procollagen C-proteinase enhancer-1 (PCPE-1).Inhibition of bone morphogenetic protein 1 by native and altered forms of alpha2-macroglobulin.Furin is the major processing enzyme of the cardiac-specific growth factor bone morphogenetic protein 10.Use of Bmp1/Tll1 doubly homozygous null mice and proteomics to identify and validate in vivo substrates of bone morphogenetic protein 1/tolloid-like metalloproteinasesMetalloproteinases in Drosophila to humans that are central players in developmental processes.A novel DFP tripeptide motif interacts with the coagulation factor XI apple 2 domainComprehensive mass spectrometric mapping of the hydroxylated amino acid residues of the α1(V) collagen chain.Clinical and molecular characterization of 40 patients with classic Ehlers-Danlos syndrome: identification of 18 COL5A1 and 2 COL5A2 novel mutationsThe bone morphogenetic protein 1/Tolloid-like metalloproteinasesRole of dimerization and substrate exclusion in the regulation of bone morphogenetic protein-1 and mammalian tolloidα3 Chains of type V collagen regulate breast tumour growth via glypican-1.Type V Collagen in Health, Disease, and Fibrosis.Binding of procollagen C-proteinase enhancer-1 (PCPE-1) to heparin/heparan sulfate: properties and role in PCPE-1 interaction with cells.Interaction between periostin and BMP-1 promotes proteolytic activation of lysyl oxidase.A novel 2D-based approach to the discovery of candidate substrates for the metalloendopeptidase meprin.Substrate-specific modulation of a multisubstrate proteinase. C-terminal processing of fibrillar procollagens is the only BMP-1-dependent activity to be enhanced by PCPE-1.Collagen V localizes to pericellular sites during tendon collagen fibrillogenesisEnzymatic cleavage specificity of the proalpha1(V) chain processing analysed by site-directed mutagenesis.Sizzled is unique among secreted frizzled-related proteins for its ability to specifically inhibit bone morphogenetic protein-1 (BMP-1)/tolloid-like proteinases.
P2860
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P2860
Biosynthetic processing of the pro-alpha 1(V)2pro-alpha 2(V) collagen heterotrimer by bone morphogenetic protein-1 and furin-like proprotein convertases
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2002 nî lūn-bûn
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2002 թուականի Փետրուարին հրատարակուած գիտական յօդուած
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2002 թվականի փետրվարին հրատարակված գիտական հոդված
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2002年の論文
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2002年論文
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2002年論文
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2002年論文
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2002年論文
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2002年論文
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2002年论文
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name
Biosynthetic processing of the ...... in-like proprotein convertases
@ast
Biosynthetic processing of the ...... in-like proprotein convertases
@en
Biosynthetic processing of the ...... in-like proprotein convertases
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Biosynthetic processing of the ...... in-like proprotein convertases
@ast
Biosynthetic processing of the ...... in-like proprotein convertases
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Biosynthetic processing of the ...... in-like proprotein convertases
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Biosynthetic processing of the ...... in-like proprotein convertases
@ast
Biosynthetic processing of the ...... in-like proprotein convertases
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Biosynthetic processing of the ...... in-like proprotein convertases
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P2093
P2860
P3181
P356
P1476
Biosynthetic processing of the ...... in-like proprotein convertases
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P2093
Barry M Steiglitz
Christine Unsöld
William N Pappano
P2860
P304
P3181
P356
10.1074/JBC.M110003200
P407
P577
2001-12-12T00:00:00Z