Leukocyte-specific adaptor protein Grap2 interacts with hematopoietic progenitor kinase 1 (HPK1) to activate JNK signaling pathway in T lymphocytes
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Efficient T-cell receptor signaling requires a high-affinity interaction between the Gads C-SH3 domain and the SLP-76 RxxK motifHIP-55 is important for T-cell proliferation, cytokine production, and immune responsesTumorigenesis suppressor Pdcd4 down-regulates mitogen-activated protein kinase kinase kinase kinase 1 expression to suppress colon carcinoma cell invasionModeling host genetic regulation of influenza pathogenesis in the collaborative crossInvolvement of hematopoietic progenitor kinase 1 in T cell receptor signalingHematopoietic progenitor kinase 1 associates physically and functionally with the adaptor proteins B cell linker protein and SLP-76 in lymphocytesDetection of Grb-2-related adaptor protein gene (GRAP) and peptide molecule in salivary glands of MRL/lpr mice and patients with Sjögren's syndromeMona/Gads SH3C binding to hematopoietic progenitor kinase 1 (HPK1) combines an atypical SH3 binding motif, R/KXXK, with a classical PXXP motif embedded in a polyproline type II (PPII) helixProstaglandin E2 activates HPK1 kinase activity via a PKA-dependent pathway.Gads/Grb2-mediated association with LAT is critical for the inhibitory function of Gab2 in T cellsThe role of Gads in hematopoietic cell signalling.Host genetic determinants of influenza pathogenicity.HPK1 associates with SKAP-HOM to negatively regulate Rap1-mediated B-lymphocyte adhesion.Protein phosphatase 4 is a positive regulator of hematopoietic progenitor kinase 1.Down-regulation of B cell receptor signaling by hematopoietic progenitor kinase 1 (HPK1)-mediated phosphorylation and ubiquitination of activated B cell linker protein (BLNK).PRAK suppresses oncogenic ras-induced hematopoietic cancer development by antagonizing the JNK pathway.Attenuation of T cell receptor signaling by serine phosphorylation-mediated lysine 30 ubiquitination of SLP-76 protein.Pdcd4 knockdown up-regulates MAP4K1 expression and activation of AP-1 dependent transcription through c-Myc.Effect of (211)At alpha-particle irradiation on expression of selected radiation responsive genes in human lymphocytes.A systems medicine approach for finding target proteins affecting treatment outcomes in patients with non-Hodgkin lymphoma.
P2860
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P2860
Leukocyte-specific adaptor protein Grap2 interacts with hematopoietic progenitor kinase 1 (HPK1) to activate JNK signaling pathway in T lymphocytes
description
2001 nî lūn-bûn
@nan
2001 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի մարտին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Leukocyte-specific adaptor pro ...... aling pathway in T lymphocytes
@ast
Leukocyte-specific adaptor pro ...... aling pathway in T lymphocytes
@en
Leukocyte-specific adaptor pro ...... aling pathway in T lymphocytes
@nl
type
label
Leukocyte-specific adaptor pro ...... aling pathway in T lymphocytes
@ast
Leukocyte-specific adaptor pro ...... aling pathway in T lymphocytes
@en
Leukocyte-specific adaptor pro ...... aling pathway in T lymphocytes
@nl
prefLabel
Leukocyte-specific adaptor pro ...... aling pathway in T lymphocytes
@ast
Leukocyte-specific adaptor pro ...... aling pathway in T lymphocytes
@en
Leukocyte-specific adaptor pro ...... aling pathway in T lymphocytes
@nl
P2093
P2860
P356
P1433
P1476
Leukocyte-specific adaptor pro ...... aling pathway in T lymphocytes
@en
P2093
P2860
P2888
P304
P356
10.1038/SJ.ONC.1204224
P407
P577
2001-03-29T00:00:00Z