PBK/TOPK is a novel mitotic kinase which is upregulated in Burkitt's lymphoma and other highly proliferative malignant cells
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Identification of the oncogenic kinase TOPK/PBK as a master mitotic regulator of C2H2 zinc finger proteinsPBK/TOPK interacts with the DBD domain of tumor suppressor p53 and modulates expression of transcriptional targets including p21Comprehensive expression profiling of tumor cell lines identifies molecular signatures of melanoma progression.The molecular basis of genistein-induced mitotic arrest and exit of self-renewal in embryonal carcinoma and primary cancer cell linesShared TP53 gene mutation in morphologically and phenotypically distinct concurrent primary small cell neuroendocrine carcinoma and adenocarcinoma of the prostate.Prognostic and predictive value of TOPK stratified by KRAS and BRAF gene alterations in sporadic, hereditary and metastatic colorectal cancer patients.T-LAK cell-originated protein kinase (TOPK) phosphorylation of Prx1 at Ser-32 prevents UVB-induced apoptosis in RPMI7951 melanoma cells through the regulation of Prx1 peroxidase activity.A porcine gene, PBK, differentially expressed in the longissimus muscle from Meishan and Large White pig.Expression of PBK/TOPK in cervical cancer and cervical intraepithelial neoplasia.Coffee phenolic phytochemicals suppress colon cancer metastasis by targeting MEK and TOPKTargeting PBK/TOPK decreases growth and survival of glioma initiating cells in vitro and attenuates tumor growth in vivoTOPK is highly expressed in circulating tumor cells, enabling metastasis of prostate cancerInterleukin-6 and its receptor, key players in hepatobiliary inflammation and cancerRegulation of distinct branches of the non-canonical Wnt-signaling network in Xenopus dorsal marginal zone explantsLymphokine-activated killer T-cell-originated protein kinase phosphorylation of histone H2AX prevents arsenite-induced apoptosis in RPMI7951 melanoma cells.Phosphorylation of IκBα at serine 32 by T-lymphokine-activated killer cell-originated protein kinase is essential for chemoresistance against doxorubicin in cervical cancer cells.Gossypol-Induced Differentiation in Human Leukemia HL-60 Cells.PDZ-binding kinase/T-LAK cell-originated protein kinase is a target of the fucoidan from brown alga Fucus evanescens in the prevention of EGF-induced neoplastic cell transformation and colon cancer growthPBK/TOPK Expression Predicts Prognosis in Oral CancerStable interference of EWS-FLI1 in an Ewing sarcoma cell line impairs IGF-1/IGF-1R signalling and reveals TOPK as a new target.Pantoprazole, an FDA-approved proton-pump inhibitor, suppresses colorectal cancer growth by targeting T-cell-originated protein kinase.Phosphorylation of TOPK at Y74, Y272 by Src increases the stability of TOPK and promotes tumorigenesis of colonPDZ binding kinase (PBK) is a theranostic target for nasopharyngeal carcinoma: driving tumor growth via ROS signaling and correlating with patient survivalRadiation-inducible miR-770-5p sensitizes tumors to radiation through direct targeting of PDZ-binding kinase.T cell-based targeted immunotherapies for patients with multiple myeloma.T-LAK cell-originated protein kinase presents a novel therapeutic target in FLT3-ITD mutated acute myeloid leukemia.Immunohistochemistry-based prognostic biomarkers in NSCLC: novel findings on the road to clinical use?The Protective Role of the TOPK/PBK Pathway in Myocardial Ischemia/Reperfusion and H₂O₂-Induced Injury in H9C2 Cardiomyocytes.Proton pump inhibitor ilaprazole suppresses cancer growth by targeting T-cell-originated protein kinaseTOPK/PBK promotes cell migration via modulation of the PI3K/PTEN/AKT pathway and is associated with poor prognosis in lung cancer.PBK/TOPK promotes tumour cell proliferation through p38 MAPK activity and regulation of the DNA damage response.Ginsenoside Rh2 inhibiting HCT116 colon cancer cell proliferation through blocking PDZ-binding kinase/T-LAK cell-originated protein kinase.TOPK and PTEN participate in CHFR mediated mitotic checkpoint.Transcriptomic analyses identify association between mitotic kinases, PDZ-binding kinase and BUB1, and clinical outcome in breast cancer.PBK/TOPK expression in non-small-cell lung cancer: its correlation and prognostic significance with Ki67 and p53 expression.Impact of a novel biomarker, T-LAK cell-originating protein kinase (TOPK) expression on outcome in malignant glioma.Enhanced Expression of the Key Mitosis Regulator Cyclin B1 Is Mediated by PDZ-Binding Kinase in Islets of Pregnant Mice.In silico structural and functional analysis of the human TOPK protein by structure modeling and molecular dynamics studies.Overexpression of T-LAK cell-originated protein kinase predicts poor prognosis in patients with stage I lung adenocarcinoma.MicroRNA-216b-3p inhibits lung adenocarcinoma cell growth via regulating PDZ binding kinase/T-LAK-cell-originated protein kinase.
P2860
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P2860
PBK/TOPK is a novel mitotic kinase which is upregulated in Burkitt's lymphoma and other highly proliferative malignant cells
description
2001 nî lūn-bûn
@nan
2001 թուականին հրատարակուած գիտական յօդուած
@hyw
2001 թվականին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
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name
PBK/TOPK is a novel mitotic ki ...... proliferative malignant cells
@ast
PBK/TOPK is a novel mitotic ki ...... proliferative malignant cells
@en
PBK/TOPK is a novel mitotic ki ...... proliferative malignant cells
@nl
type
label
PBK/TOPK is a novel mitotic ki ...... proliferative malignant cells
@ast
PBK/TOPK is a novel mitotic ki ...... proliferative malignant cells
@en
PBK/TOPK is a novel mitotic ki ...... proliferative malignant cells
@nl
prefLabel
PBK/TOPK is a novel mitotic ki ...... proliferative malignant cells
@ast
PBK/TOPK is a novel mitotic ki ...... proliferative malignant cells
@en
PBK/TOPK is a novel mitotic ki ...... proliferative malignant cells
@nl
P2093
P3181
P356
P1476
PBK/TOPK is a novel mitotic ki ...... proliferative malignant cells
@en
P2093
A P Rapoport
D Kalvakolanu
J A Toretsky
K Bailey-Dell
M Simons-Evelyn
P3181
P356
10.1006/BCMD.2001.0452
P407
P577
2001-01-01T00:00:00Z