The costimulation-regulated duration of PKB activation controls T cell longevity
about
CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanismsThe intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the gamesCostimulation by CD137/4-1BB inhibits T cell apoptosis and induces Bcl-xL and c-FLIP(short) via phosphatidylinositol 3-kinase and AKT/protein kinase B.Association of interacting genes in the toll-like receptor signaling pathway and the antibody response to pertussis vaccinationCD27 sustains survival of CTLs in virus-infected nonlymphoid tissue in mice by inducing autocrine IL-2 production.Control of immunity by the TNFR-related molecule OX40 (CD134)OX40 facilitates control of a persistent virus infection.OX40 costimulation can abrogate Foxp3+ regulatory T cell-mediated suppression of antitumor immunity.Signals from OX40 regulate nuclear factor of activated T cells c1 and T cell helper 2 lineage commitment.Antigen-independent signalosome of CARMA1, PKCθ, and TNF receptor-associated factor 2 (TRAF2) determines NF-κB signaling in T cellsTNF receptor-associated factor 3 is required for T cell-mediated immunity and TCR/CD28 signalingIntrinsic IL-21 signaling is critical for CD8 T cell survival and memory formation in response to vaccinia viral infection.Regulation of A1 by OX40 contributes to CD8(+) T cell survival and anti-tumor activity.The significance of OX40 and OX40L to T-cell biology and immune disease.Herpesvirus entry mediator (TNFRSF14) regulates the persistence of T helper memory cell populations.Targeting OX40 promotes lung-resident memory CD8 T cell populations that protect against respiratory poxvirus infectionNew insights on OX40 in the control of T cell immunity and immune tolerance in vivoTherapeutic targeting of the effector T-cell co-stimulatory molecule OX40.The role of apoptosis in the development and function of T lymphocytes.Functional reprogramming of the primary immune response by T cell receptor antagonism.SDF-1α degrades whereas glycoprotein 120 upregulates Bcl-2 interacting mediator of death extralong isoform: implications for the development of T cell memoryThe small molecule TGF-β signaling inhibitor SM16 synergizes with agonistic OX40 antibody to suppress established mammary tumors and reduce spontaneous metastasis.Activation of NF-kappaB1 by OX40 contributes to antigen-driven T cell expansion and survival.Immune regulation and control of regulatory T cells by OX40 and 4-1BBA critical role for direct TLR2-MyD88 signaling in CD8 T-cell clonal expansion and memory formation following vaccinia viral infection.Enhanced T cell apoptosis within Drak2-deficient mice promotes resistance to autoimmunityHypercostimulation through 4-1BB distorts homeostasis of immune cells.OX40 drives protective vaccinia virus-specific CD8 T cells.The role of TNF superfamily members in T-cell function and diseases.Integrating costimulatory agonists to optimize immune-based cancer therapies.The role of OX40-mediated co-stimulation in T-cell activation and survival.Soluble OX40L and JAG1 Induce Selective Proliferation of Functional Regulatory T-Cells Independent of canonical TCR signalingICOSL expression in human bone marrow-derived mesenchymal stem cells promotes induction of regulatory T cells.Signaling through OX40 enhances antitumor immunity.Regulation of PI-3-Kinase and Akt Signaling in T Lymphocytes and Other Cells by TNFR Family MoleculesThe contextual role of TNFR family members in CD8(+) T-cell control of viral infections.T-cell costimulatory blockade in organ transplantation.Roles for TNF-receptor associated factor 3 (TRAF3) in lymphocyte functions.Various ways to improve whole cancer cell vaccines.The Ox40/Ox40 Ligand Pathway Promotes Pathogenic Th Cell Responses, Plasmablast Accumulation, and Lupus Nephritis in NZB/W F1 Mice.
P2860
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P2860
The costimulation-regulated duration of PKB activation controls T cell longevity
description
2004 nî lūn-bûn
@nan
2004 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
The costimulation-regulated duration of PKB activation controls T cell longevity
@ast
The costimulation-regulated duration of PKB activation controls T cell longevity
@en
The costimulation-regulated duration of PKB activation controls T cell longevity
@nl
type
label
The costimulation-regulated duration of PKB activation controls T cell longevity
@ast
The costimulation-regulated duration of PKB activation controls T cell longevity
@en
The costimulation-regulated duration of PKB activation controls T cell longevity
@nl
prefLabel
The costimulation-regulated duration of PKB activation controls T cell longevity
@ast
The costimulation-regulated duration of PKB activation controls T cell longevity
@en
The costimulation-regulated duration of PKB activation controls T cell longevity
@nl
P2093
P2860
P921
P356
P1433
P1476
The costimulation-regulated duration of PKB activation controls T cell longevity
@en
P2093
Jianxun Song
Luk Van Parijs
Mary Cheng
Michael Croft
Paul R Rogers
Shahram Salek-Ardakani
P2860
P356
10.1038/NI1030
P407
P577
2004-02-01T00:00:00Z