A monoclonal antibody that targets a NaV1.7 channel voltage sensor for pain and itch relief - Test2 - elhamkhani - TriplyDB

A monoclonal antibody that targets a NaV1.7 channel voltage sensor for pain and itch relief

A monoclonal antibody that targets a NaV1.7 channel voltage sensor for pain and itch relief

http://www.wikidata.org/entity/Q28240662

about

Anti-nerve growth factor in pain management: current evidence Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade.Intrathecal bone marrow stromal cells inhibit neuropathic pain via TGF-β secretion.Advances in understanding itching and scratching: a new era of targeted treatments Neuroimmune interactions in itch: Do chronic itch, chronic pain, and chronic cough share similar mechanisms?Endogenous opioids contribute to insensitivity to pain in humans and mice lacking sodium channel Nav1.7 Nav1.7 and other voltage-gated sodium channels as drug targets for pain relief Global Nav1.7 knockout mice recapitulate the phenotype of human congenital indifference to pain Modeling nociception in zebrafish: a way forward for unbiased analgesic discovery Inhibition of Inactive States of Tetrodotoxin-Sensitive Sodium Channels Reduces Spontaneous Firing of C-Fiber Nociceptors and Produces Analgesia in Formalin and Complete Freund's Adjuvant Models of Pain Evaluation of recombinant monoclonal antibody SVmab1 binding to Na V1.7 target sequences and block of human Na V1.7 currents Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release.Information processing in the CNS: a supramolecular chemistry?New Horizons in Diabetic Neuropathy: Mechanisms, Bioenergetics, and Pain.Toll-like receptor 4 contributes to chronic itch, alloknesis, and spinal astrocyte activation in male mice Insensitivity to pain induced by a potent selective closed-state Nav1.7 inhibitor.β-arrestin-2 regulates NMDA receptor function in spinal lamina II neurons and duration of persistent pain.Affimer proteins are versatile and renewable affinity reagents Defining the nociceptor transcriptome.Bacterial voltage-gated sodium channels (BacNa(V)s) from the soil, sea, and salt lakes enlighten molecular mechanisms of electrical signaling and pharmacology in the brain and heart.A surface plasmon resonance approach to monitor toxin interactions with an isolated voltage-gated sodium channel paddle motif.Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway.Temporal dynamics of anxiety phenotypes in a dental pulp injury model Role of anoctamin-1 and bestrophin-1 in spinal nerve ligation-induced neuropathic pain in rats.Novel sodium channel antagonists in the treatment of neuropathic pain.Matrix Metalloproteinase (MMP) Proteolysis of the Extracellular Loop of Voltage-gated Sodium Channels and Potential Alterations in Pain Signaling.A monoclonal antibody against KCNK9 K(+) channel extracellular domain inhibits tumour growth and metastasis.Transient Receptor Potential Vanilloid 4 Ion Channel Functions as a Pruriceptor in Epidermal Keratinocytes to Evoke Histaminergic Itch.Peripheral Brain Derived Neurotrophic Factor Precursor Regulates Pain as an Inflammatory Mediator Disrupting the dynamic equilibrium of ORAI channels determines the phenotype of malignant cells Engineering Highly Potent and Selective Microproteins against Nav1.7 Sodium Channel for Treatment of Pain.Sodium channel Nav1.7 expression is upregulated in the dorsal root ganglia in a rat model of paclitaxel-induced peripheral neuropathy.MicroRNA-30b regulates expression of the sodium channel Nav1.7 in nerve injury-induced neuropathic pain in the rat Hierarchical CRMP2 posttranslational modifications control NaV1.7 function.Discovery of functional antibodies targeting ion channels.New horizons in therapeutic antibody discovery: opportunities and challenges versus small-molecule therapeutics.Toward a Mechanism-Based Approach to Pain Diagnosis.The voltage-gated sodium channel NaV 1.9 in visceral pain.Combining Human and Rodent Genetics to Identify New Analgesics.Functional Studies of Sodium Channels: From Target to Compound Identification.

P2860

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P2860

A monoclonal antibody that targets a NaV1.7 channel voltage sensor for pain and itch relief

http://www.wikidata.org/entity/Q28240662

description

2014 nî lūn-bûn

@nan

2014 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի հունիսին հրատարակված գիտական հոդված

@hy

2014年の論文

@ja

2014年論文

@yue

2014年論文

@zh-hant

2014年論文

@zh-hk

2014年論文

@zh-mo

2014年論文

@zh-tw

2014年论文

@wuu

name

A monoclonal antibody that tar ...... ensor for pain and itch relief

@ast

A monoclonal antibody that tar ...... ensor for pain and itch relief

@en

A monoclonal antibody that tar ...... ensor for pain and itch relief

@nl

type

label

A monoclonal antibody that tar ...... ensor for pain and itch relief

@ast

A monoclonal antibody that tar ...... ensor for pain and itch relief

@en

A monoclonal antibody that tar ...... ensor for pain and itch relief

@nl

prefLabel

A monoclonal antibody that tar ...... ensor for pain and itch relief

@ast

A monoclonal antibody that tar ...... ensor for pain and itch relief

@en

A monoclonal antibody that tar ...... ensor for pain and itch relief

@nl

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J.CELL.2014.03.064

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A monoclonal antibody that tar ...... ensor for pain and itch relief

@en

P2093

Chul-Kyu Park

http://www.w3.org/2001/XMLSchema#string

Gang Chen

http://www.w3.org/2001/XMLSchema#string

Qingjian Han

http://www.w3.org/2001/XMLSchema#string

Rou-Gang Xie

http://www.w3.org/2001/XMLSchema#string

Seok-Yong Lee

http://www.w3.org/2001/XMLSchema#string

Tong Liu

http://www.w3.org/2001/XMLSchema#string

P2860

X-ray structure of a voltage-dependent K+ channel

Discovery of a selective NaV1.7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain models.

Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons

Neuronal circuitry for pain processing in the dorsal horn

Charge movement associated with the opening and closing of the activation gates of the Na channels

Portability of paddle motif function and pharmacology in voltage sensors

The crystal structure of a voltage-gated sodium channel

New insights into the mechanisms of itch: are pain and itch controlled by distinct mechanisms?

SCN9A mutations in paroxysmal extreme pain disorder: allelic variants underlie distinct channel defects and phenotypes

Reengineering biopharmaceuticals for targeted delivery across the blood-brain barrier

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1393-404

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scholarly article

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6

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157

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24856969

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4098795

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