Central pore residues mediate the p97/VCP activity required for ERAD
about
Defining human ERAD networks through an integrative mapping strategyRecognition of C-terminal amino acids in tubulin by pore loops in Spastin is important for microtubule severingRegulation of retrotranslocation by p97-associated deubiquitinating enzyme ataxin-3OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERADDefining the human deubiquitinating enzyme interaction landscapeRegulation of endoplasmic reticulum-associated degradation by RNF5-dependent ubiquitination of JNK-associated membrane protein (JAMP)The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ERRNF185 is a novel E3 ligase of endoplasmic reticulum-associated degradation (ERAD) that targets cystic fibrosis transmembrane conductance regulator (CFTR)Inhibition of p97-dependent protein degradation by Eeyarestatin IThe homozygote VCP(R¹⁵⁵H/R¹⁵⁵H) mouse model exhibits accelerated human VCP-associated disease pathologyInactivation of VCP/ter94 suppresses retinal pathology caused by misfolded rhodopsin in DrosophilaBiochemical and Structural Studies of Yeast Vps4 OligomerizationStructural Insights on the Mycobacterium tuberculosis Proteasomal ATPase MpaThe crystal structure of apo-FtsH reveals domain movements necessary for substrate unfolding and translocation.An intersubunit signaling network coordinates ATP hydrolysis by m-AAA proteasesNucleotide-dependent conformational changes of the AAA+ ATPase p97 revisitedEndoplasmic reticulum-associated ubiquitin-conjugating enzyme Ube2j1 is a novel substrate of MK2 (MAPKAP kinase-2) involved in MK2-mediated TNFα productionCleaning up in the endoplasmic reticulum: ubiquitin in chargeHereditary inclusion body myopathy-linked p97/VCP mutations in the NH2 domain and the D1 ring modulate p97/VCP ATPase activity and D2 ring conformationControl of p97 function by cofactor bindingTargeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein HomeostasisStructure-activity relationship study reveals ML240 and ML241 as potent and selective inhibitors of p97 ATPaseReversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathwaysPositive cooperativity of the p97 AAA ATPase is critical for essential functionsOTUB1 overexpression in mesangial cells is a novel regulator in the pathogenesis of glomerulonephritis through the decrease of DCN levelVCP mutations causing frontotemporal lobar degeneration disrupt localization of TDP-43 and induce cell death.Molecular snapshots of the Pex1/6 AAA+ complex in action.Unfolding the mechanism of the AAA+ unfoldase VAT by a combined cryo-EM, solution NMR study.Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers.Withaferin A Analogs That Target the AAA+ Chaperone p97.Dissecting the N-ethylmaleimide-sensitive factor: required elements of the N and D1 domainsThe endoplasmic reticulum-associated degradation of the epithelial sodium channel requires a unique complement of molecular chaperones.Role of intramembrane charged residues in the quality control of unassembled T-cell receptor alpha-chains at the endoplasmic reticulumSelective inhibition of p97 by chlorinated analogues of dehydrocurvularinA Mighty "Protein Extractor" of the Cell: Structure and Function of the p97/CDC48 ATPase.Inclusion body myopathy, Paget's disease of the bone and fronto-temporal dementia: a disorder of autophagyDeviation of the typical AAA substrate-threading pore prevents fatal protein degradation in yeast Cdc48.Specific inhibition of p97/VCP ATPase and kinetic analysis demonstrate interaction between D1 and D2 ATPase domainsThe final moments of misfolded proteins en route to the proteasome.BAT3 guides misfolded glycoproteins out of the endoplasmic reticulum.
P2860
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P2860
Central pore residues mediate the p97/VCP activity required for ERAD
description
2006 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի մայիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2006
@ast
im Mai 2006 veröffentlichter wissenschaftlicher Artikel
@de
scientific article (publication date: 19 May 2006)
@en
vedecký článok (publikovaný 2006/05/19)
@sk
vědecký článek publikovaný v roce 2006
@cs
wetenschappelijk artikel (gepubliceerd op 2006/05/19)
@nl
наукова стаття, опублікована в травні 2006
@uk
مقالة علمية (نشرت في 19-5-2006)
@ar
name
Central pore residues mediate the p97/VCP activity required for ERAD
@ast
Central pore residues mediate the p97/VCP activity required for ERAD
@en
Central pore residues mediate the p97/VCP activity required for ERAD
@nl
type
label
Central pore residues mediate the p97/VCP activity required for ERAD
@ast
Central pore residues mediate the p97/VCP activity required for ERAD
@en
Central pore residues mediate the p97/VCP activity required for ERAD
@nl
prefLabel
Central pore residues mediate the p97/VCP activity required for ERAD
@ast
Central pore residues mediate the p97/VCP activity required for ERAD
@en
Central pore residues mediate the p97/VCP activity required for ERAD
@nl
P3181
P1433
P1476
Central pore residues mediate the p97/VCP activity required for ERAD
@en
P2093
Byron DeLaBarre
Ron R Kopito
P304
P3181
P356
10.1016/J.MOLCEL.2006.03.036
P407
P577
2006-05-19T00:00:00Z