The discovery of capsazepine, the first competitive antagonist of the sensory neuron excitants capsaicin and resiniferatoxin
about
Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assayPhytochemicals for the Management of MelanomaTRPV1 Channel: A Potential Drug Target for Treating EpilepsyOptical control of TRPV1 channelsQSAR and docking studies on capsazepine derivatives for immunomodulatory and anti-inflammatory activityPharmacological blockade of TRPM8 ion channels alters cold and cold pain responses in miceTRPV1: A Potential Drug Target for Treating Various Diseases.Characterization of in vitro metabolism of capsazepine, a vanilloid transient receptor potential channel antagonist, by liquid chromatography quadrupole ion trap mass spectrometry.TRPV1 activation counters diet-induced obesity through sirtuin-1 activation and PRDM-16 deacetylation in brown adipose tissue.Activation of the TRPV1 cation channel contributes to stress-induced astrocyte migrationRole of TRPV1 channels in ischemia/reperfusion-induced acute kidney injury.Structure-activity relationship of capsaicin analogs and transient receptor potential vanilloid 1-mediated human lung epithelial cell toxicity.Interference of TRPV1 function altered the susceptibility of PTZ-induced seizuresThe stimulation of capsaicin-sensitive neurones in a vanilloid receptor-mediated fashion by pungent terpenoids possessing an unsaturated 1,4-dialdehyde moietyDynasore blocks evoked release while augmenting spontaneous synaptic transmission from primary visceral afferents.Resiniferatoxin for Pain Treatment: An Interventional Approach to Personalized Pain Medicine.Endocannabinoids and endovanilloids: a possible balance in the regulation of the testicular GnRH signallingInhibition of fatty acid amide hydrolase activates Nrf2 signalling and induces heme oxygenase 1 transcription in breast cancer cellsIon channel blockers for the treatment of neuropathic pain.Screening TRPV1 antagonists for the treatment of pain: lessons learned over a decade.Opposite effect of capsaicin and capsazepine on behavioral thermoregulation in insectsTumour-Derived Glutamate: Linking Aberrant Cancer Cell Metabolism to Peripheral Sensory Pain PathwaysEmerging Targets in Photopharmacology.Transient Receptor Potential Channels in Microglia: Roles in Physiology and Disease.Structure-Driven Pharmacology of Transient Receptor Potential Channel Vanilloid 1.Novel scaffolds for modulation of TRPV1 identified with pharmacophore modeling and virtual screening.The Transient Receptor Potential Vanilloid 1 Antagonist Capsazepine Improves the Impaired Lung Mechanics during Endotoxemia.Synthesis, high-throughput screening and pharmacological characterization of β-lactam derivatives as TRPM8 antagonists.Design, synthesis, insecticidal activity, and structure-activity relationship (SAR): studies of novel triazone derivatives containing a urea bridge group based on transient receptor potential (TRP) channels.Photoswitchable fatty acids enable optical control of TRPV1.Effect of capsaicin and analogues on potassium and calcium currents and vanilloid receptors in Xenopus embryo spinal neurones1,2-Bis(bromo-meth-yl)-4,5-dimethoxy-benzene.TRPV1 antagonist capsazepine suppresses 4-AP-induced epileptiform activity in vitro and electrographic seizures in vivo.Microsomal omega-hydroxylated metabolites of N-arachidonoyl dopamine are active at recombinant human TRPV1 receptors.Capsaicin-, resiniferatoxin-, and olvanil-induced adrenaline secretions in rats via the vanilloid receptor.Identification of species-specific determinants of the action of the antagonist capsazepine and the agonist PPAHV on TRPV1.Capsazepine concentration dependently inhibits currents in HEK 293 cells mediated by human hyperpolarization-activated cyclic nucleotide-gated 2 and 4 channels.Natural product modulators of human sensations and mood: molecular mechanisms and therapeutic potential.Design, synthesis and biological evaluation of B-region modified diarylalkyl amide analogues as novel TRPV1 antagonists.Capsaicin, nonivamide and trans-pellitorine decrease free fatty acid uptake without TRPV1 activation and increase acetyl-coenzyme A synthetase activity in Caco-2 cells.
P2860
Q24672180-EC281FBD-DD04-4E3D-9DD5-7F3EBFE8CC1FQ26766708-954142BD-AC11-4F9E-B494-EE6766102FFFQ26786478-73AE18AF-284D-435F-B5E5-17CA7476C7C1Q28294957-D0F9067B-37BD-4ECE-8B43-A74C2C17A7D1Q28389712-358DD97C-056C-4B05-AB42-8743CDC6D09CQ28477318-4AAE1B45-394B-4473-A658-9A07CDE9202AQ30434994-D086DEC8-6101-4B91-A4D4-AA86F990DC45Q33619537-72A2044D-D4C4-440E-9DAB-311CEE49B887Q33627453-5234112B-BC53-4CAB-A9A3-D808E71808F6Q33934830-9A4F0F5F-E122-441F-9EA9-93FC229B1519Q34361800-9AF13C78-9E65-42F8-B92B-6D2232564C54Q34868207-ABD966DE-5616-4595-9434-A966F3CDE3C0Q35067058-4010B066-2F20-4FE1-853C-4633542CBFC4Q35884647-2254E1CE-9CFB-4B00-9608-79143074A326Q36328379-FB8AFD7A-D423-45D4-A013-7375B152898BQ36458451-128FC2C8-9BFF-4385-BDB4-C0B090112EEFQ37171969-DB42974F-086E-4BCB-A73A-C2F126632796Q37219066-7D862D2E-23A6-46D4-8631-A4A4B3D1E0DFQ37855929-C54E9A7E-EF34-4AAA-8184-5F4217D8BED7Q38088356-A910F6A8-4CBF-4344-B824-07C34F1BAA77Q38524395-BE77DDEF-6ECE-4B9D-9593-037B0A0720ABQ38828988-01EF93CC-47B9-4139-87F1-A199CF171AF4Q38845495-27861745-DAF1-42E4-BDCB-7B8182B34D0FQ38853425-4F728EB8-4B4C-4CD5-AB55-085498B63439Q38874068-71E45144-4A9A-4D9D-845C-BAC3F56BEA33Q39023266-4D18B4B4-BCDA-4630-899A-7088AF7C5401Q40709500-EDB0E043-896F-403B-ACBF-3B0CE8A86277Q41545232-71759683-99F1-4919-8AD7-8EF72E940C10Q41991167-C5F8AE6F-6084-4700-8879-F9A9A02FFB32Q42089811-372B4DE0-0F92-468E-AD2B-9040F68C9598Q42239723-B2F70823-323E-4C98-9FF2-A1EEB4F81E77Q42387422-0A78935E-B248-403F-BB9E-AD2BAB4FBABFQ42740630-CEC412F5-0E10-4444-AC52-CA93E03E45FAQ43184096-6C2E18CC-2537-4735-962D-85C474833CA4Q43854871-C9803B36-1812-4BFD-BAC4-D9161CE5A579Q44762642-42D398A2-607B-4179-A332-6FED2795718AQ45386818-0BC0CAD8-FF62-4CD9-80D5-E1916B59125FQ47652702-23BB2AA5-FA57-44DC-B72D-2C8FF719EE22Q47782984-0E9A415D-64E9-4438-BD5F-B29F906DFBC5Q50456769-CB2DA562-ABA3-4D5E-AA86-775D8F65B248
P2860
The discovery of capsazepine, the first competitive antagonist of the sensory neuron excitants capsaicin and resiniferatoxin
description
1994 nî lūn-bûn
@nan
1994 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
The discovery of capsazepine, ...... capsaicin and resiniferatoxin
@ast
The discovery of capsazepine, ...... capsaicin and resiniferatoxin
@en
The discovery of capsazepine, ...... capsaicin and resiniferatoxin
@nl
type
label
The discovery of capsazepine, ...... capsaicin and resiniferatoxin
@ast
The discovery of capsazepine, ...... capsaicin and resiniferatoxin
@en
The discovery of capsazepine, ...... capsaicin and resiniferatoxin
@nl
prefLabel
The discovery of capsazepine, ...... capsaicin and resiniferatoxin
@ast
The discovery of capsazepine, ...... capsaicin and resiniferatoxin
@en
The discovery of capsazepine, ...... capsaicin and resiniferatoxin
@nl
P2093
P356
P1476
The discovery of capsazepine, ...... capsaicin and resiniferatoxin
@en
P2093
C S Walpole
G A Hughes
G Bovermann
J J Boelsterli
J W Davies
R Breckenridge
P304
P356
10.1021/JM00039A006
P407
P50
P577
1994-06-01T00:00:00Z