Oncogenic signaling from the hematopoietic growth factor receptors c-Kit and Flt3
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Class III Receptor Tyrosine Kinases in Acute Leukemia - Biological Functions and Modern Laboratory AnalysisSTAT5-regulated microRNA-193b controls haematopoietic stem and progenitor cell expansion by modulating cytokine receptor signalling.Receptor Signaling Directs Global Recruitment of Pre-existing Transcription Factors to Inducible ElementsDistinct patterns of DNA damage response and apoptosis correlate with Jak/Stat and PI3kinase response profiles in human acute myelogenous leukemiaExpression of GADS enhances FLT3-induced mitogenic signaling.Group 2 innate lymphoid cell production of IL-5 is regulated by NKT cells during influenza virus infectionGAS6 expression identifies high-risk adult AML patients: potential implications for therapyBlocking autocrine VEGF signaling by sunitinib, an anti-cancer drug, promotes embryonic stem cell self-renewal and somatic cell reprogramming.Src-Like adaptor protein (SLAP) binds to the receptor tyrosine kinase Flt3 and modulates receptor stability and downstream signaling.Complex interactions in EML cell stimulation by stem cell factor and IL-3Oncogenic tyrosine kinases target Dok-1 for ubiquitin-mediated proteasomal degradation to promote cell transformationMutations in the transmembrane and juxtamembrane domains enhance IL27R transforming activityPhase I pharmacokinetic and pharmacodynamic study of the multikinase inhibitor sorafenib in combination with clofarabine and cytarabine in pediatric relapsed/refractory leukemia.The IKAROS interaction with a complex including chromatin remodeling and transcription elongation activities is required for hematopoiesis.Online nanoflow multidimensional fractionation for high efficiency phosphopeptide analysisKIT with D816 mutations cooperates with CBFB-MYH11 for leukemogenesis in mice.Bortezomib interferes with C-KIT processing and transforms the t(8;21)-generated fusion proteins into tumor-suppressing fragments in leukemia cells.Clinical and pharmacodynamic activity of bortezomib and decitabine in acute myeloid leukemia.Generation and characterization of a highly effective protein substrate for analysis of FLT3 activityFlt3L is a novel regulator of skeletal myogenesisMolecular characteristics of malignant ovarian germ cell tumors and comparison with testicular counterparts: implications for pathogenesis.Axl/Gas6 pathway positively regulates FLT3 activation in human natural killer cell developmentPathogenesis, classification and treatment of mastocytosis: state of the art in 2010 and future perspectives.Differential signaling of Flt3 activating mutations in acute myeloid leukemia: a working model.Molecular genetics of testicular germ cell tumors.STAT5 acetylation: Mechanisms and consequences for immunological control and leukemogenesis.SOCS proteins in regulation of receptor tyrosine kinase signaling.c-Cbl and Cbl-b ligases mediate 17-allylaminodemethoxygeldanamycin-induced degradation of autophosphorylated Flt3 kinase with internal tandem duplication through the ubiquitin proteasome pathway.Aberrant activation of the PI3K/mTOR pathway promotes resistance to sorafenib in AML.Overview of fundamental study of pazopanib in cancer.Tyrosine 842 in the activation loop is required for full transformation by the oncogenic mutant FLT3-ITD.ABL2 suppresses FLT3-ITD-induced cell proliferation through negative regulation of AKT signaling.The activation loop tyrosine 823 is essential for the transforming capacity of the c-Kit oncogenic mutant D816V.Antileukemic effects of midostaurin in acute myeloid leukemia - the possible importance of multikinase inhibition in leukemic as well as nonleukemic stromal cells.Phosphorylation of the activation loop tyrosine 823 in c-Kit is crucial for cell survival and proliferation.Suppressor of cytokine signaling 2 (SOCS2) associates with FLT3 and negatively regulates downstream signaling.KIT-D816V oncogenic activity is controlled by the juxtamembrane docking site Y568-Y570.FLT3 signals via the adapter protein Grb10 and overexpression of Grb10 leads to aberrant cell proliferation in acute myeloid leukemiaSuppressor of cytokine signaling 6 (SOCS6) negatively regulates Flt3 signal transduction through direct binding to phosphorylated tyrosines 591 and 919 of Flt3.Silencing of ETV6/RUNX1 abrogates PI3K/AKT/mTOR signaling and impairs reconstitution of leukemia in xenografts.
P2860
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P2860
Oncogenic signaling from the hematopoietic growth factor receptors c-Kit and Flt3
description
2009 nî lūn-bûn
@nan
2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Oncogenic signaling from the hematopoietic growth factor receptors c-Kit and Flt3
@ast
Oncogenic signaling from the hematopoietic growth factor receptors c-Kit and Flt3
@en
Oncogenic signaling from the hematopoietic growth factor receptors c-Kit and Flt3
@nl
type
label
Oncogenic signaling from the hematopoietic growth factor receptors c-Kit and Flt3
@ast
Oncogenic signaling from the hematopoietic growth factor receptors c-Kit and Flt3
@en
Oncogenic signaling from the hematopoietic growth factor receptors c-Kit and Flt3
@nl
prefLabel
Oncogenic signaling from the hematopoietic growth factor receptors c-Kit and Flt3
@ast
Oncogenic signaling from the hematopoietic growth factor receptors c-Kit and Flt3
@en
Oncogenic signaling from the hematopoietic growth factor receptors c-Kit and Flt3
@nl
P3181
P1433
P1476
Oncogenic signaling from the hematopoietic growth factor receptors c-Kit and Flt3
@en
P2093
Kristina Masson
Lars Rönnstrand
P304
P3181
P356
10.1016/J.CELLSIG.2009.06.002
P407
P577
2009-12-01T00:00:00Z