Efficient discovery of anti-inflammatory small-molecule combinations using evolutionary computing
about
Individuality, phenotypic differentiation, dormancy and 'persistence' in culturable bacterial systems: commonalities shared by environmental, laboratory, and clinical microbiologyStructure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive reviewMetabolomics and systems pharmacology: why and how to model the human metabolic network for drug discoveryFenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer's disease in rodent modelsQSAR modeling: where have you been? Where are you going to?High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells.P38 and JNK have opposing effects on persistence of in vivo leukocyte migration in zebrafish.A strategy for the identification of combinatorial bioactive compounds contributing to the holistic effect of herbal medicines.Finding novel pharmaceuticals in the systems biology era using multiple effective drug targets, phenotypic screening and knowledge of transporters: where drug discovery went wrong and how to fix it.On the translocation of bacteria and their lipopolysaccharides between blood and peripheral locations in chronic, inflammatory diseases: the central roles of LPS and LPS-induced cell death.Diverse array-designed modes of combination therapies in Fangjiomics.Regional brain shrinkage and change in cognitive performance over two years: The bidirectional influences of the brain and cognitive reserve factorsAge and sex related differences in subcortical brain iron concentrations among healthy adults.Predicting Drug Combination Index and Simulating the Network-Regulation Dynamics by Mathematical Modeling of Drug-Targeted EGFR-ERK Signaling Pathway.Network pharmacology strategies toward multi-target anticancer therapies: from computational models to experimental design principles.The role of inflammation and interleukin-1 in acute cerebrovascular disease.Existing and Developing Approaches for QSAR Analysis of Mixtures.Neighbor communities in drug combination networks characterize synergistic effect.Closed-loop optimization of chromatography column sizing strategies in biopharmaceutical manufacture.A 'rule of 0.5' for the metabolite-likeness of approved pharmaceutical drugs.Scientific discovery as a combinatorial optimisation problem: how best to navigate the landscape of possible experiments?A novel method for assessing the role of iron and its functional chelation in fibrin fibril formation: the use of scanning electron microscopy.Network Pharmacology Strategies Toward Multi-Target Anticancer Therapies: From Computational Models to Experimental Design Principles.On handling ephemeral resource constraints in evolutionary search.No effects without causes: the Iron Dysregulation and Dormant Microbes hypothesis for chronic, inflammatory diseases.
P2860
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P2860
Efficient discovery of anti-inflammatory small-molecule combinations using evolutionary computing
description
2011 nî lūn-bûn
@nan
2011 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Efficient discovery of anti-in ...... s using evolutionary computing
@ast
Efficient discovery of anti-in ...... s using evolutionary computing
@en
Efficient discovery of anti-in ...... s using evolutionary computing
@nl
type
label
Efficient discovery of anti-in ...... s using evolutionary computing
@ast
Efficient discovery of anti-in ...... s using evolutionary computing
@en
Efficient discovery of anti-in ...... s using evolutionary computing
@nl
prefLabel
Efficient discovery of anti-in ...... s using evolutionary computing
@ast
Efficient discovery of anti-in ...... s using evolutionary computing
@en
Efficient discovery of anti-in ...... s using evolutionary computing
@nl
P2860
P50
P3181
P356
P1476
Efficient discovery of anti-in ...... s using evolutionary computing
@en
P2093
Joshua Knowles
Nancy J Rothwell
P2860
P2888
P3181
P356
10.1038/NCHEMBIO.689
P407
P50
P577
2011-10-23T00:00:00Z