Acetyl-coenzyme A carboxylase: crucial metabolic enzyme and attractive target for drug discovery
about
A symmetrical tetramer for S. aureus pyruvate carboxylase in complex with coenzyme AStructural evidence for direct interactions between the BRCT domains of human BRCA1 and a phospho-peptide from human ACC1Crystal structure of biotin carboxylase in complex with substrates and implications for its catalytic mechanismMicroRNAs and oncogenic transcriptional regulatory networks controlling metabolic reprogramming in cancersObesity pharmacotherapy: current perspectives and future directionsStructure and function of biotin-dependent carboxylasesInfluence of neonatal hypothyroidism on hepatic gene expression and lipid metabolism in adulthoodThe dynamic organization of fungal acetyl-CoA carboxylase.Structural diversity in the six-fold redundant set of acyl-CoA carboxyltransferases in Mycobacterium tuberculosisDomain architecture of pyruvate carboxylase, a biotin-dependent multifunctional enzymeA different mechanism for the inhibition of the carboxyltransferase domain of acetyl-coenzyme A carboxylase by tepraloxydimCrystal structure of the α6β6 holoenzyme of propionyl-coenzyme A carboxylaseMechanism for the inhibition of the carboxyltransferase domain of acetyl-coenzyme A carboxylase by pinoxadenStructural and Biochemical Studies on the Regulation of Biotin Carboxylase by Substrate Inhibition and DimerizationStructure-Guided Expansion of the Substrate Range of Methylmalonyl Coenzyme A Synthetase (MatB) of Rhodopseudomonas palustrisStructure-guided Inhibitor Design for Human Acetyl-coenzyme A Carboxylase by Interspecies Active Site ConversionCharacterizing the Importance of the Biotin Carboxylase Domain Dimer for Staphylococcus aureus Pyruvate Carboxylase CatalysisAn unanticipated architecture of the 750-kDa α6β6 holoenzyme of 3-methylcrotonyl-CoA carboxylaseCrystal Structure of Urea Carboxylase Provides Insights into the Carboxyltransfer ReactionACCase 6 is the essential acetyl-CoA carboxylase involved in fatty acid and mycolic acid biosynthesis in mycobacteriaPleiotropic effect of AccD5 and AccE5 depletion in acyl-coenzyme A carboxylase activity and in lipid biosynthesis in mycobacteriaProteomic analysis of carbon concentrating chemolithotrophic bacteria Serratia sp. for sequestration of carbon dioxideImproving production of malonyl coenzyme A-derived metabolites by abolishing Snf1-dependent regulation of Acc1GPR40 agonist ameliorates liver X receptor-induced lipid accumulation in liver by activating AMPK pathwayStructure and function of a single-chain, multi-domain long-chain acyl-CoA carboxylase.Early evolution of the biotin-dependent carboxylase family.Identifying essential genes in bacterial metabolic networks with machine learning methodsThe Mycobacterium tuberculosis cytochrome P450 system.Lipid metabolism enzyme ACSVL3 supports glioblastoma stem cell maintenance and tumorigenicityLow birth weight male guinea pig offspring display increased visceral adiposity in early adulthood.Identification of ligand binding sites of proteins using the Gaussian Network Model.Proteomic analysis of the carotenogenic yeast Xanthophyllomyces dendrorhous.Rosiglitazone and fenofibrate improve insulin sensitivity of pre-diabetic OLETF rats by reducing malonyl-CoA levels in the liver and skeletal muscleGene expression profiles of a mouse congenic strain carrying an obesity susceptibility QTL under obesigenic dietsDengue virus nonstructural protein 3 redistributes fatty acid synthase to sites of viral replication and increases cellular fatty acid synthesis.Acetylation of malate dehydrogenase 1 promotes adipogenic differentiation via activating its enzymatic activity.Screening of small molecules affecting mammalian P-body assembly uncovers links with diverse intracellular processes and organelle physiology.Structure-based inhibitor design of AccD5, an essential acyl-CoA carboxylase carboxyltransferase domain of Mycobacterium tuberculosisPET imaging of tumor glycolysis downstream of hexokinase through noninvasive measurement of pyruvate kinase M2.Comparative Analysis of Xenorhabdus koppenhoeferi Gene Expression during Symbiotic Persistence in the Host Nematode.
P2860
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P2860
Acetyl-coenzyme A carboxylase: crucial metabolic enzyme and attractive target for drug discovery
description
2005 nî lūn-bûn
@nan
2005 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Acetyl-coenzyme A carboxylase: ...... tive target for drug discovery
@ast
Acetyl-coenzyme A carboxylase: ...... tive target for drug discovery
@en
Acetyl-coenzyme A carboxylase: ...... tive target for drug discovery
@nl
type
label
Acetyl-coenzyme A carboxylase: ...... tive target for drug discovery
@ast
Acetyl-coenzyme A carboxylase: ...... tive target for drug discovery
@en
Acetyl-coenzyme A carboxylase: ...... tive target for drug discovery
@nl
prefLabel
Acetyl-coenzyme A carboxylase: ...... tive target for drug discovery
@ast
Acetyl-coenzyme A carboxylase: ...... tive target for drug discovery
@en
Acetyl-coenzyme A carboxylase: ...... tive target for drug discovery
@nl
P3181
P1476
Acetyl-coenzyme A carboxylase: ...... tive target for drug discovery
@en
P2093
P2888
P304
P3181
P356
10.1007/S00018-005-5121-4
P407
P50
P577
2005-08-01T00:00:00Z