Chemogenomics: an emerging strategy for rapid target and drug discovery - Test2 - elhamkhani - TriplyDB

Chemogenomics: an emerging strategy for rapid target and drug discovery

Chemogenomics: an emerging strategy for rapid target and drug discovery

http://www.wikidata.org/entity/Q28260664

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Genome-scale screening of drug-target associations relevant to Ki using a chemogenomics approach Chemogenomic profiling on a genome-wide scale using reverse-engineered gene networks Zebrafish whole-adult-organism chemogenomics for large-scale predictive and discovery chemical biology Bioassays to monitor Taspase1 function for the identification of pharmacogenetic inhibitors Mining relational paths in integrated biomedical data In silico repositioning-chemogenomics strategy identifies new drugs with potential activity against multiple life stages of Schistosoma mansoni Predicting drug target interactions using meta-path-based semantic network analysis Applications of chemogenomic library screening in drug discovery Machine learning for in silico virtual screening and chemical genomics: new strategies A Chemogenomic Screen Reveals Novel Snf1p/AMPK Independent Regulators of Acetyl-CoA Carboxylase Chemogenomics and orthology-based design of antibiotic combination therapies ExCAPE-DB: an integrated large scale dataset facilitating Big Data analysis in chemogenomics Entropy-scaling search of massive biological data Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics.Computational Prediction of DrugTarget Interactions Using Chemical, Biological, and Network Features.3D Structure, Dimerization Modeling, and Lead Discovery by Ligand-protein Interaction Analysis of p60 Transcription Regulator Protein (p60TRP).Enhancing reproducibility in cancer drug screening: how do we move forward?Characterizing protein domain associations by Small-molecule ligand binding Data integration: challenges for drug discovery.A comparison of machine learning algorithms for chemical toxicity classification using a simulated multi-scale data model.Chemical proteomics from a nuclear magnetic resonance spectroscopy perspective.Chemogenomics approaches to novel target discovery.Supporting retrieval of diverse biomedical data using evidence-aware queries.A pairwise chemical genetic screen identifies new inhibitors of glucose transport.Creation and manipulation of common functional groups en route to a skeletally diverse chemical library Phenotypic screening of phylomer peptide libraries derived from genome fragments to identify and validate new targets and therapeutics.Translocation Biosensors - Cellular System Integrators to Dissect CRM1-Dependent Nuclear Export by Chemicogenomics.Selectively targeting the DNA-binding domain of the androgen receptor as a prospective therapy for prostate cancer.Cell biology, chemogenomics and chemoproteomics - application to drug discovery.A chemogenomics based approach for deorphanization of testicular receptor 4: An orphan receptor of nuclear receptor superfamily.Network measures for chemical library design.Genomic characterization of Alzheimer's disease and genotype-related phenotypic analysis of biological markers in dementia.TargetNet: a web service for predicting potential drug-target interaction profiling via multi-target SAR models.Chemogenetic profiling identifies RAD17 as synthetically lethal with checkpoint kinase inhibition.Patient-Derived Xenografts as a Model System for Radiation Research Quantifying the relationships among drug classes Antibacterials from the sea.A decade of the human genome sequence--how does the medicinal chemist benefit?Cell-based apoptosis assays in oncology drug discovery.Selecting oral bioavailability enhancing formulations during drug discovery and development.

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Chemogenomics: an emerging strategy for rapid target and drug discovery

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Chemogenomics: an emerging strategy for rapid target and drug discovery

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Chemogenomics: an emerging strategy for rapid target and drug discovery

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Chemogenomics: an emerging strategy for rapid target and drug discovery

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Edgar Jacoby

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Markus Bredel

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Initial sequencing and analysis of the human genome

The Sequence of the Human Genome

Gene ontology: tool for the unification of biology

TTD: Therapeutic Target Database

The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2

Gene expression profiles derived from fine needle aspiration correlate with response to systemic chemotherapy in breast cancer.

Basic local alignment search tool

Novel functions of the phosphatidylinositol metabolic pathway discovered by a chemical genomics screen with wortmannin

Correlation between protein and mRNA abundance in yeast

High-throughput screening of small molecules in miniaturized mammalian cell-based assays involving post-translational modifications

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10.1038/NRG1317

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