Paxillin is a target for somatic mutations in lung cancer: implications for cell growth and invasion - Test2 - elhamkhani - TriplyDB

Paxillin is a target for somatic mutations in lung cancer: implications for cell growth and invasion

Paxillin is a target for somatic mutations in lung cancer: implications for cell growth and invasion

http://www.wikidata.org/entity/Q28263339

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The MET axis as a therapeutic target.Identification and functional characterization of paxillin as a target of protein tyrosine phosphatase receptor T FAK and paxillin, two potential targets in pancreatic cancer c-Jun N-Terminal Kinases Mediate a Wide Range of Targets in the Metastatic Cascade Role of mesenchymal-epithelial transition amplification in resistance to anti-epidermal growth factor receptor agents MET molecular mechanisms and therapies in lung cancer Paxillin expression and amplification in early lung lesions of high-risk patients, lung adenocarcinoma and metastatic disease Proteomic characterization of non-small cell lung cancer in a comprehensive translational thoracic oncology database Paxillin mediates sensing of physical cues and regulates directional cell motility by controlling lamellipodia positioning Calpain-mediated proteolysis of paxillin negatively regulates focal adhesion dynamics and cell migration.The MET receptor tyrosine kinase is a potential novel therapeutic target for head and neck squamous cell carcinoma.Chemo-resistant protein expression pattern of glioblastoma cells (A172) to perillyl alcohol.Paxillin mutations affect focal adhesions and lead to altered mitochondrial dynamics: relevance to lung cancer Role of PAX8 in the regulation of MET and RON receptor tyrosine kinases in non-small cell lung cancer.Significance of talin in cancer progression and metastasis.MET and PI3K/mTOR as a potential combinatorial therapeutic target in malignant pleural mesothelioma.Emerging role of paxillin-PKL in regulation of cell adhesion, polarity and migration Abnormal expression of paxillin correlates with tumor progression and poor survival in patients with gastric cancer.Fascin-1, ezrin and paxillin contribute to the malignant progression and are predictors of clinical prognosis in laryngeal squamous cell carcinoma.p190RhoGEF (Rgnef) promotes colon carcinoma tumor progression via interaction with focal adhesion kinase.CK2 inhibitor CX-4945 blocks TGF-β1-induced epithelial-to-mesenchymal transition in A549 human lung adenocarcinoma cells.RON (MST1R) is a novel prognostic marker and therapeutic target for gastroesophageal adenocarcinoma.The role of the c-Met pathway in lung cancer and the potential for targeted therapy.DNA repair biomarkers XPF and phospho-MAPKAP kinase 2 correlate with clinical outcome in advanced head and neck cancer Bcl-2 stabilization by paxillin confers 5-fluorouracil resistance in colorectal cancer.A novel aminothiazole KY-05009 with potential to inhibit Traf2- and Nck-interacting kinase (TNIK) attenuates TGF-β1-mediated epithelial-to-mesenchymal transition in human lung adenocarcinoma A549 cells HOXA5 inhibits metastasis via regulating cytoskeletal remodelling and associates with prolonged survival in non-small-cell lung carcinoma Paxillin promotes colorectal tumor invasion and poor patient outcomes via ERK-mediated stabilization of Bcl-2 protein by phosphorylation at Serine 87.Expression of Paxillin is Correlated with Clinical Prognosis in Colorectal Cancer Patients Deciphering Mode of Action of Functionally Important Regions in the Intrinsically Disordered Paxillin (Residues 1-313) Using Its Interaction with FAT (Focal Adhesion Targeting Domain of Focal Adhesion Kinase).Paxillin mediates extranuclear and intranuclear signaling in prostate cancer proliferation.Expression of paxillin in laryngeal squamous cell carcinoma and its prognostic value Novel Small Molecule JP-153 Targets the Src-FAK-Paxillin Signaling Complex to Inhibit VEGF-Induced Retinal Angiogenesis.Diverse roles for the paxillin family of proteins in cancer.Mutation testing for directing upfront targeted therapy and post-progression combination therapy strategies in lung adenocarcinoma.MET as a target for treatment of chest tumors MET pathway as a therapeutic target.Paxillin: a crossroad in pathological cell migration Paxillin controls endothelial cell migration and tumor angiogenesis by altering neuropilin 2 expression.MET genetic lesions in non-small-cell lung cancer: pharmacological and clinical implications.

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P2860

Paxillin is a target for somatic mutations in lung cancer: implications for cell growth and invasion

http://www.wikidata.org/entity/Q28263339

description

2008 nî lūn-bûn

@nan

2008 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի հունվարին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

Paxillin is a target for somat ...... s for cell growth and invasion

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Paxillin is a target for somat ...... s for cell growth and invasion

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Paxillin is a target for somat ...... s for cell growth and invasion

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type

label

Paxillin is a target for somat ...... s for cell growth and invasion

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Paxillin is a target for somat ...... s for cell growth and invasion

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Paxillin is a target for somat ...... s for cell growth and invasion

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prefLabel

Paxillin is a target for somat ...... s for cell growth and invasion

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Paxillin is a target for somat ...... s for cell growth and invasion

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Paxillin is a target for somat ...... s for cell growth and invasion

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0008-5472.CAN-07-1998

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Cancer Research

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A Craig Mackinnon

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Aliya N Husain

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Gavin J Gordon

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Hanna Surawska

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John Minna

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Leonardo Faoro

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Lioubov Soulii

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Livia L Szeto

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Luc Girard

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Maria S Tretiakova

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P2860

Digital karyotyping

Leupaxin is a critical adaptor protein in the adhesion zone of the osteoclast

Integrin-regulated FAK-Src signaling in normal and cancer cells

Molecular cloning of human paxillin, a focal adhesion protein phosphorylated by P210BCR/ABL

Characterization of the TGF beta 1-inducible hic-5 gene that encodes a putative novel zinc finger protein and its possible involvement in cellular senescence

Monocyte cells and cancer cells express novel paxillin isoforms with different binding properties to focal adhesion proteins

Amplification of MET may identify a subset of cancers with extreme sensitivity to the selective tyrosine kinase inhibitor PHA-665752

Identification of LIM3 as the principal determinant of paxillin focal adhesion localization and characterization of a novel motif on paxillin directing vinculin and focal adhesion kinase binding.

Paxillin interactions

p21-activated kinases in cancer

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132-42

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1902968

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10.1158/0008-5472.CAN-07-1998

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1

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68

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David J. Sugarbaker

Everett E Vokes

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2008-01-01T00:00:00Z

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5678108

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2767335

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