Apolipoprotein E: diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer's disease
about
Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's diseaseRosiglitazone increases dendritic spine density and rescues spine loss caused by apolipoprotein E4 in primary cortical neuronsThe potential of pathological protein fragmentation in blood-based biomarker development for dementia - with emphasis on Alzheimer's diseaseStructural basis for the recognition and cross-linking of amyloid fibrils by human apolipoprotein EIn silico analysis of the apolipoprotein E and the amyloid beta peptide interaction: misfolding induced by frustration of the salt bridge networkThe apolipoprotein E (APOE) gene appears functionally monomorphic in chimpanzees (Pan troglodytes)Proteomic analysis of mitochondria in APOE transgenic mice and in response to an ischemic challengeGene sequences regulating the production of apoE and cerebral palsy of variable severity.Apolipoprotein E4 domain interaction: synaptic and cognitive deficits in miceGABAergic interneuron dysfunction impairs hippocampal neurogenesis in adult apolipoprotein E4 knockin mice.IQ, educational attainment, memory and plasma lipids: associations with apolipoprotein E genotype in 5995 children.Epigenetic signature and enhancer activity of the human APOE gene.Cognitive decline and brain pathology in aging--need for a dimensional, lifespan and systems vulnerability view.The vascular contribution to Alzheimer's disease.The C-terminal alpha-helix domain of apolipoprotein E is required for interaction with nonstructural protein 5A and assembly of hepatitis C virus.Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicityApolipoprotein E: from lipid transport to neurobiologyApolipoprotein E: structure and function in lipid metabolism, neurobiology, and Alzheimer's diseases.C-terminal-truncated apolipoprotein (apo) E4 inefficiently clears amyloid-beta (Abeta) and acts in concert with Abeta to elicit neuronal and behavioral deficits in mice.Extracellular proteolysis of apolipoprotein E (apoE) by secreted serine neuronal proteaseMultiple SNPs within and surrounding the apolipoprotein E gene influence cerebrospinal fluid apolipoprotein E protein levels.Genetic Dissection of Tissue-Specific Apolipoprotein E Function for Hypercholesterolemia and Diet-Induced Obesity.Apolipoprotein E polymorphism is associated with susceptibility to schizophrenia among Saudis.Lipid homeostasis and apolipoprotein E in the development and progression of Alzheimer's disease.Lifelong vitamin E intake retards age-associated decline of spatial learning ability in apoE-deficient mice.Apolipoprotein E alleles can contribute to the pathogenesis of numerous clinical conditions including HSV-1 corneal disease.ApoE derived from adipose tissue does not suppress atherosclerosis or correct hyperlipidemia in apoE knockout miceDiurnal variations in salivary protein carbonyl levels in normal and cognitively impaired human subjects.Apolipoprotein (apo) E4 and Alzheimer's disease: unique conformational and biophysical properties of apoE4 can modulate neuropathology.Novel modulators of amyloid-beta precursor protein processing.Study on potential role of apolipoprotein E in recurrent pregnancy loss.Apolipoprotein E and neurological disease: therapeutic potential and pharmacogenomic interactions.Apolipoprotein E and cholesterol in aging and disease in the brainNeuronal protein trafficking associated with Alzheimer disease: from APP and BACE1 to glutamate receptorsUnderstanding the association of apolipoprotein E4 with Alzheimer disease: clues from its structure.Activation of the amyloid cascade in apolipoprotein E4 transgenic mice induces lysosomal activation and neurodegeneration resulting in marked cognitive deficitsDisentangling the effects of age and APOE on neuropathology and late life cognitive declineApolipoprotein E4 domain interaction induces endoplasmic reticulum stress and impairs astrocyte function.Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation.Reduced phosphorylation of brain insulin receptor substrate and Akt proteins in apolipoprotein-E4 targeted replacement mice.
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P2860
Apolipoprotein E: diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer's disease
description
2004 nî lūn-bûn
@nan
2004 թուականին հրատարակուած գիտական յօդուած
@hyw
2004 թվականին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Apolipoprotein E: diversity of ...... effects in Alzheimer's disease
@ast
Apolipoprotein E: diversity of ...... effects in Alzheimer's disease
@en
Apolipoprotein E: diversity of ...... effects in Alzheimer's disease
@nl
type
label
Apolipoprotein E: diversity of ...... effects in Alzheimer's disease
@ast
Apolipoprotein E: diversity of ...... effects in Alzheimer's disease
@en
Apolipoprotein E: diversity of ...... effects in Alzheimer's disease
@nl
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Apolipoprotein E: diversity of ...... effects in Alzheimer's disease
@ast
Apolipoprotein E: diversity of ...... effects in Alzheimer's disease
@en
Apolipoprotein E: diversity of ...... effects in Alzheimer's disease
@nl
P2093
P356
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Apolipoprotein E: diversity of ...... effects in Alzheimer's disease
@en
P2093
Karl H Weisgraber
Lennart Mucke
Robert W Mahley
Yadong Huang
P2888
P304
P356
10.1385/JMN:23:3:189
P407
P577
2004-01-01T00:00:00Z
P6179
1012126439