Knowledge of the proposed chemical mechanism of action and cytochrome p450 metabolism of antimalarial trioxanes like artemisinin allows rational design of new antimalarial peroxides
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A plausible mechanism for the antimalarial activity of artemisinin: A computational approachChallenging Density Functional Theory Calculations with Hemes and PorphyrinsCapturing Biological Activity in Natural Product Fragments by Chemical SynthesisChiral phosphoric acid catalyzed peroxidation of iminesDihydroartemisinin enhances Apo2L/TRAIL-mediated apoptosis in pancreatic cancer cells via ROS-mediated up-regulation of death receptor 5The lipophilic bullet hits the targets: medicinal chemistry of adamantane derivativesNox4-dependent ROS modulation by amino endoperoxides to induce apoptosis in cancer cellsDesign, synthesis, and study of a mycobactin-artemisinin conjugate that has selective and potent activity against tuberculosis and malariaPlasmodium drug targets outside the genetic control of the parasite.Drug discovery for malaria: a very challenging and timely endeavorThe therapeutic potential of semi-synthetic artemisinin and synthetic endoperoxide antimalarial agents.The Nonartemisinin Sesquiterpene Lactones Parthenin and Parthenolide Block Plasmodium falciparum Sexual Stage Transmission.Catalytic enantioselective peroxidation of alpha,beta-unsaturated ketonesOkundoperoxide, a bicyclic cyclofarnesylsesquiterpene endoperoxide from Scleria striatinux with antiplasmodial activity.Artemisinin and its derivatives: a novel class of anti-malarial and anti-cancer agents.Qinghaosu (artemisinin): chemistry and pharmacology.Metabolic engineering for the production of clinically important molecules: Omega-3 fatty acids, artemisinin, and taxol.Tetraoxanes: synthetic and medicinal chemistry perspective.Synthesis of five- and six-membered cyclic organic peroxides: Key transformations into peroxide ring-retaining products.RIP1-dependent reactive oxygen species production executes artesunate-induced cell death in renal carcinoma Caki cells.Malaria treatment using novel nano-based drug delivery systems.Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs.Catalytic asymmetric peroxidation of α,β-unsaturated nitroalkenes by a bifunctional organic catalyst.Probing the Peroxycarbenium [3+2] Cycloaddition Reactions with 1,2-Disubstituted Ethylenes: Results and Insights.Chemiluminescent identification and quantification of artemisinin and relevant sesquiterpene lactone derivatives.Potent antimalarial 1,2,4-trioxanes through perhydrolysis of epoxides.Simple analogues of qinghaosu (artemisinin).Four-step synthesis of the antimalarial cardamom peroxide via an oxygen stitching strategy.Endoperoxide synthesis by photocatalytic aerobic [2 + 2 + 2] cycloadditions3-Alkoxy-1,2-Dioxolanes: Synthesis and Evaluation as Potential Antimalarial Agents.Clausena anisata and Dysphania ambrosioides essential oils: from ethno-medicine to modern uses as effective insecticides.Efficient and selective synthesis of α,β-epoxy-γ-butyrolactones from 2-peroxy-1,4-dicarbonyl compounds.Design, synthesis and antimalarial activity of trifluoromethylartemisinin-mefloquine dual molecules.Enantiomeric 1,2,4-trioxanes display equivalent in vitro antimalarial activity versus Plasmodium falciparum malaria parasites: implications for the molecular mechanism of action of the artemisinins.Reactivity Patterns of (Protonated) Compound II and Compound I of Cytochrome P450: Which is the Better Oxidant?Cu-based carbene involved in a radical process: a new crossover reaction to construct γ-peroxy esters and 1,4-dicarbonyl compounds.Synthesis and Study of the Antimalarial Cardamom PeroxideChemiluminescence from the biomimetic reaction of 1,2,4-trioxolanes and 1,2,4,5-tetroxanes with ferrous ions
P2860
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P2860
Knowledge of the proposed chemical mechanism of action and cytochrome p450 metabolism of antimalarial trioxanes like artemisinin allows rational design of new antimalarial peroxides
description
2004 nî lūn-bûn
@nan
2004 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Knowledge of the proposed chem ...... of new antimalarial peroxides
@ast
Knowledge of the proposed chem ...... of new antimalarial peroxides
@en
Knowledge of the proposed chem ...... of new antimalarial peroxides
@nl
type
label
Knowledge of the proposed chem ...... of new antimalarial peroxides
@ast
Knowledge of the proposed chem ...... of new antimalarial peroxides
@en
Knowledge of the proposed chem ...... of new antimalarial peroxides
@nl
prefLabel
Knowledge of the proposed chem ...... of new antimalarial peroxides
@ast
Knowledge of the proposed chem ...... of new antimalarial peroxides
@en
Knowledge of the proposed chem ...... of new antimalarial peroxides
@nl
P3181
P356
P1476
Knowledge of the proposed chem ...... of new antimalarial peroxides
@en
P2093
Gary H Posner
Paul M O'Neill
P304
P3181
P356
10.1021/AR020227U
P407
P577
2004-06-01T00:00:00Z