N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen - Test2 - elhamkhani - TriplyDB

N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen

N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen

http://www.wikidata.org/entity/Q28268181

about

Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes Mechanisms of acetaminophen-induced liver necrosis Experimental models of hepatotoxicity related to acute liver failure Xenobiotic and Endobiotic Mediated Interactions Between the Cytochrome P450 System and the Inflammatory Response in the Liver Role of reactive metabolites in the circulation in extrahepatic toxicity Role and regulation of β-catenin signaling during physiological liver growth Optimization of the bacterial cytochrome P450 BM3 system for the production of human drug metabolites Structural and Kinetic Analyses of Macrophage Migration Inhibitory Factor Active Site Interactions † ‡Free-radical metabolites of acetaminophen and a dimethylated derivative Biomonitoring Human Albumin Adducts: The Past, the Present, and the Future Mice deficient in Cu,Zn-superoxide dismutase are resistant to acetaminophen toxicity A Cytoplasmic Form of Gaussia luciferase Provides a Highly Sensitive Test for Cytotoxicity c-Jun N-terminal kinase (JNK)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice The Alzheimer pandemic: is paracetamol to blame?Selective protein arylation and acetaminophen-induced hepatotoxicity.The smart Petri dish: a nanostructured photonic crystal for real-time monitoring of living cells p-Aminophenol-induced liver toxicity: tentative evidence of a role for acetaminophen.Paracetamol (acetaminophen)-induced toxicity: molecular and biochemical mechanisms, analogues and protective approaches.Identification of the hepatic protein targets of reactive metabolites of acetaminophen in vivo in mice using two-dimensional gel electrophoresis and mass spectrometry.Probable fatal drug interaction between intravenous fenretinide, ceftriaxone, and acetaminophen: a case report from a New Approaches to Neuroblastoma (NANT) Phase I study.Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury Zinc Supplementation with Polaprezinc Protects Mouse Hepatocytes against Acetaminophen-Induced Toxicity via Induction of Heat Shock Protein 70 Gentiana manshurica Kitagawa prevents acetaminophen-induced acute hepatic injury in mice via inhibiting JNK/ERK MAPK pathway Involvement of connexin43 in acetaminophen-induced liver injury.Acetaminophen reactive intermediates target hepatic thioredoxin reductase The Impact of Sterile Inflammation in Acute Liver Injury.Acetaminophen intoxication during treatment: what you don't know can hurt you.Acetaminophen elimination half-life in humans is unaffected by short-term consumption of sulfur amino acid-free diet.Differential effect of covalent protein modification and glutathione depletion on the transcriptional response of Nrf2 and NF-kappaB.Temporal study of acetaminophen (APAP) and S-adenosyl-L-methionine (SAMe) effects on subcellular hepatic SAMe levels and methionine adenosyltransferase (MAT) expression and activity Gymnaster koraiensis and its major components, 3,5-di-O-caffeoylquinic acid and gymnasterkoreayne B, reduce oxidative damage induced by tert-butyl hydroperoxide or acetaminophen in HepG2 cells Is nuclear factor erythroid 2-related factor 2 responsible for sex differences in susceptibility to acetaminophen-induced hepatotoxicity in mice?Inhibition of the metabolism of paracetamol by isoniazid Necrostatin-1 protects against reactive oxygen species (ROS)-induced hepatotoxicity in acetaminophen-induced acute liver failure Deficiency of interleukin-15 enhances susceptibility to acetaminophen-induced liver injury in mice.Zebrafish as model organisms for studying drug-induced liver injury Aloe vera attenuated liver injury in mice with acetaminophen-induced hepatitis.Acetaminophen-NAPQI hepatotoxicity: a cell line model system genome-wide association study.Indocyanine green clearance varies as a function of N-acetylcysteine treatment in a murine model of acetaminophen toxicity.Hepatoprotective activity of Tribulus terrestris extract against acetaminophen-induced toxicity in a freshwater fish (Oreochromis mossambicus).

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P2860

N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen

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1984 nî lūn-bûn

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Proceedings of the National Academy of Sciences of the United States of America

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A Y Lu

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D C Dahlin

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G T Miwa

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P2860

Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione.

Evidence that acetaminophen and N-hydroxyacetaminophen form a common arylating intermediate, N-acetyl-p-benzoquinoneimine.

Cumene hydroperoxide-supported microsomal hydroxylations of warfarin--a probe of cytochrome P-450 multiplicity and specificity.

Studies on the association of cytochrome P-450 and NADPH-cytochrome c reductase during catalysis in a reconstituted hydroxylating system.

A simple and rapid procedure for the purification of phenobarbital-inducible cytochrome P-450 from rat liver microsomes.

N-hydroxyacetaminophen: a postulated toxic metabolite of acetaminophen.

Evidence for the involvement of N-acetyl-p- quinoneimine in acetaminophen metabolism.

Acetaminophen-induced hepatic necrosis. VI. Metabolic disposition of toxic and nontoxic doses of acetaminophen.

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5

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6424115

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