The functional Q84R polymorphism of mammalian Tribbles homolog TRB3 is associated with insulin resistance and related cardiovascular risk in Caucasians from Italy
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Genetic prediction of common diseases. Still no help for the clinical diabetologist!Insulin receptor signaling in normal and insulin-resistant statesDevelopmental roles of tribbles protein family membersThe mammalian tribbles homolog TRIB3, glucose homeostasis, and cardiovascular diseasesEffect of TRB3 on insulin and nutrient-stimulated hepatic p70 S6 kinase activityTRB3 gene silencing alleviates diabetic cardiomyopathy in a type 2 diabetic rat modelMammalian Tribbles homolog 3 impairs insulin action in skeletal muscle: role in glucose-induced insulin resistanceKnockdown of the gene encoding Drosophila tribbles homologue 3 (Trib3) improves insulin sensitivity through peroxisome proliferator-activated receptor-γ (PPAR-γ) activation in a rat model of insulin resistanceAmino acid availability controls TRB3 transcription in liver through the GCN2/eIF2α/ATF4 pathwayENPP1 affects insulin action and secretion: evidences from in vitro studies.The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse beta cells.Tribbles homolog 3 attenuates mammalian target of rapamycin complex-2 signaling and inflammation in the diabetic kidneyDrosophila tribbles antagonizes insulin signaling-mediated growth and metabolism via interactions with Akt kinaseActivation of calcium/calmodulin-dependent protein kinase II in obesity mediates suppression of hepatic insulin signaling.The ENPP1 Q121 variant predicts major cardiovascular events in high-risk individuals: evidence for interaction with obesity in diabetic patients.Joint effect of insulin signaling genes on all-cause mortality.Association of TRB3 Q84R polymorphism with polycystic ovary syndrome in Chinese womenMagnolol administration in normotensive young spontaneously hypertensive rats postpones the development of hypertension: role of increased PPAR gamma, reduced TRB3 and resultant alleviative vascular insulin resistance.Tribbles homolog 3 denotes a poor prognosis in breast cancer and is involved in hypoxia response.The role of intracellular signaling in insulin-mediated regulation of drug metabolizing enzyme gene and protein expression.Silence of TRIB3 suppresses atherosclerosis and stabilizes plaques in diabetic ApoE-/-/LDL receptor-/- mice.Role of TRIB3 in diabetic and overnutrition-induced atherosclerosis.Regulation of hepatic TRB3/Akt interaction induced by physical exercise and its effect on the hepatic glucose production in an insulin resistance stateLeucine supplementation increases SIRT1 expression and prevents mitochondrial dysfunction and metabolic disorders in high-fat diet-induced obese mice.Joint effect of insulin signaling genes on cardiovascular events and on whole body and endothelial insulin resistance.Decreased serum obestatin consequent upon TRIB3 Q84R polymorphism exacerbates carotid atherosclerosis in subjects with metabolic syndrome.Variants of insulin-signaling inhibitor genes in type 2 diabetes and related metabolic abnormalities.Infrequent TRIB3 coding variants and coronary artery disease in type 2 diabetes.The TRIB3 Q84R polymorphism and risk of early-onset type 2 diabetesTRIB3 functional Q84R polymorphism is a risk factor for metabolic syndrome and carotid atherosclerosis.Mammalian tribbles homologs at the crossroads of endoplasmic reticulum stress and Mammalian target of rapamycin pathways.Assessment of Human Tribbles Homolog 3 Genetic Variation (rs2295490) Effects on Type 2 Diabetes Patients with Glucose Control and Blood Pressure Lowering Treatment.Sitagliptin prevents aggravation of endocrine and exocrine pancreatic damage in the Zucker Diabetic Fatty rat - focus on amelioration of metabolic profile and tissue cytoprotective propertiesAkt signaling in platelets and thrombosis.Tribbles in disease: Signaling pathways important for cellular function and neoplastic transformation.Tribbles: 'puzzling' regulators of cell signalling.Insulin receptor signaling and glucagon-like peptide 1 effects on pancreatic beta cells.TRB3: an oxidant stress-induced pseudokinase with a potential to negatively modulate MCP-1 cytokine in diabetic nephropathy.The TRIB3 R84 variant is associated with increased carotid intima-media thickness in vivo and with enhanced MAPK signalling in human endothelial cells.Fatty acids differentially regulate insulin resistance through endoplasm reticulum stress-mediated induction of tribbles homologue 3: a potential link between dietary fat composition and the pathophysiological outcomes of obesity.
P2860
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P2860
The functional Q84R polymorphism of mammalian Tribbles homolog TRB3 is associated with insulin resistance and related cardiovascular risk in Caucasians from Italy
description
2005 nî lūn-bûn
@nan
2005 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
The functional Q84R polymorphi ...... risk in Caucasians from Italy
@ast
The functional Q84R polymorphi ...... risk in Caucasians from Italy
@en
The functional Q84R polymorphi ...... risk in Caucasians from Italy
@nl
type
label
The functional Q84R polymorphi ...... risk in Caucasians from Italy
@ast
The functional Q84R polymorphi ...... risk in Caucasians from Italy
@en
The functional Q84R polymorphi ...... risk in Caucasians from Italy
@nl
prefLabel
The functional Q84R polymorphi ...... risk in Caucasians from Italy
@ast
The functional Q84R polymorphi ...... risk in Caucasians from Italy
@en
The functional Q84R polymorphi ...... risk in Caucasians from Italy
@nl
P2093
P50
P921
P1433
P1476
The functional Q84R polymorphi ...... risk in Caucasians from Italy
@en
P2093
Eleonora Morini
Federica Turchi
Marina Cardellini
Marta Letizia Hribal
Renato Lauro
Simonetta Bacci
Vittorio Tassi
P304
P356
10.2337/DIABETES.54.9.2807
P407
P50
P577
2005-09-01T00:00:00Z