Intracellular calcium increase in epileptiform activity: modulation by levetiracetam and lamotrigine - Test2 - elhamkhani - TriplyDB

Intracellular calcium increase in epileptiform activity: modulation by levetiracetam and lamotrigine

Intracellular calcium increase in epileptiform activity: modulation by levetiracetam and lamotrigine

http://www.wikidata.org/entity/Q28269848

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Molecular targets for antiepileptic drug development Seletracetam (UCB 44212)New in vitro phenotypic assay for epilepsy: fluorescent measurement of synchronized neuronal calcium oscillations Levetiracetam: the profile of a novel anticonvulsant drug-part I: preclinical data.MEK inhibitor PD98059 acutely inhibits synchronized spontaneous Ca2+ oscillations in cultured hippocampal networks.Down-regulation of BK channel expression in the pilocarpine model of temporal lobe epilepsy.Levetiracetam inhibits glutamate transmission through presynaptic P/Q-type calcium channels on the granule cells of the dentate gyrus.Sustained down-regulation of β-dystroglycan and associated dysfunctions of astrocytic endfeet in epileptic cerebral cortex.Attenuation of the effects of corticosteroids on declarative memory with lamotrigine.Levetiracetam Prevents Perforin Mediated Neuronal Injury Induced by Acute Cerebral Ischemia Reperfusion.A randomized, double-blind, placebo-controlled, trial of lamotrigine therapy in bipolar disorder, depressed or mixed phase and cocaine dependence.Anti-Epileptic Drug Combination Efficacy in an In Vitro Seizure Model - Phenytoin and Valproate, Lamotrigine and Valproate.Development of the calcium plateau following status epilepticus: role of calcium in epileptogenesis.Lamotrigine and its applications in the treatment of epilepsy and other neurological and psychiatric disorders.Bipolar disorder: involvement of signaling cascades and AMPA receptor trafficking at synapses.Is levetiracetam different from other antiepileptic drugs? Levetiracetam and its cellular mechanism of action in epilepsy revisited.P/Q-type calcium channel modulators.Mechanisms of levetiracetam in the control of status epilepticus and epilepsy.Recent patents on calcium channel blockers: emphasis on CNS diseases.Neuroprotection as a Potential Therapeutic Perspective in Neurodegenerative Diseases: Focus on Antiepileptic Drugs.Brivaracetam: Rationale for discovery and preclinical profile of a selective SV2A ligand for epilepsy treatment.Review: Cav2.3 R-type Voltage-Gated Ca2+ Channels - Functional Implications in Convulsive and Non-convulsive Seizure Activity.Effects of anti-epileptic drugs on spreading depolarization-induced epileptiform activity in mouse hippocampal slices.Dramatic Response After Lamotrigine in a Patient With Epileptic Encephalopathy and a De NovoCACNA1A Variant.The calmodulin-dependent protein kinase II inhibitor KN-93 protects rat cerebral cortical neurons from N-methyl-D-aspartic acid-induced injury.Modulation of action potential and calcium signaling by levetiracetam in rat sensory neurons.Inhibition of persistent sodium current fraction and voltage-gated L-type calcium current by propofol in cortical neurons: implications for its antiepileptic activity.Separation of antiepileptogenic and antiseizure effects of levetiracetam in the spontaneously epileptic rat (SER).Levetiracetam in the treatment of idiopathic generalized epilepsies.Pharmacodynamic and pharmacokinetic characterization of interactions between levetiracetam and numerous antiepileptic drugs in the mouse maximal electroshock seizure model: an isobolographic analysis.The antiepileptic drug levetiracetam stabilizes the human epileptic GABAA receptors upon repetitive activation.Levetiracetam and felbamate interact both pharmacodynamically and pharmacokinetically: an isobolographic analysis in the mouse maximal electroshock model.A novel CaV2.2 channel inhibition by piracetam in peripheral and central neurons.A review of the pharmacology and clinical efficacy of brivaracetam.Spreading depolarization, a pathophysiological mechanism of stroke and migraine aura In Situ Metabolism of Levetiracetam in Blood of Patients with Epilepsy

P2860

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P2860

Intracellular calcium increase in epileptiform activity: modulation by levetiracetam and lamotrigine

http://www.wikidata.org/entity/Q28269848

description

2004 nî lūn-bûn

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2004年の論文

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Intracellular calcium increase ...... levetiracetam and lamotrigine

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Intracellular calcium increase ...... levetiracetam and lamotrigine

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Intracellular calcium increase ...... levetiracetam and lamotrigine

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Intracellular calcium increase ...... levetiracetam and lamotrigine

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Intracellular calcium increase ...... levetiracetam and lamotrigine

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J.0013-9580.2004.02204.X

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Intracellular calcium increase ...... levetiracetam and lamotrigine

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Antonio Pisani

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Cinzia Costa

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Cristiano De Persis

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Francesco Pisani

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Giorgio Bernardi

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Giuseppina Martella

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Paola Bonsi

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Paolo Calabresi

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P2860

Selective blockade of N-type calcium channels by levetiracetam

Altered expression and assembly of N-type calcium channel alpha1B and beta subunits in epileptic lethargic (lh/lh) mouse

Prolonged activation of the N-methyl-D-aspartate receptor-Ca2+ transduction pathway causes spontaneous recurrent epileptiform discharges in hippocampal neurons in culture.

Dendritic spines as basic functional units of neuronal integration.

Cellular biology of epileptogenesis.

Differential expression and association of calcium channel subunits in development and disease.

Paroxysmal depolarization shifts induced by bicuculline in CA3 neurons of hippocampal slices: suppression by the organic calcium antagonist verapamil.

Effects of extracellular pH on the interaction of sipatrigine and lamotrigine with high-voltage-activated (HVA) calcium channels in dissociated neurones of rat cortex.

Levetiracetam inhibits the high-voltage-activated Ca(2+) current in pyramidal neurones of rat hippocampal slices.

Levetiracetam does not modulate neuronal voltage-gated Na+ and T-type Ca2+ currents.

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719-28

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3232443

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10.1111/J.0013-9580.2004.02204.X

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7

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2004-07-01T00:00:00Z

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8477431

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15230693

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