IL-21 enhances and sustains CD8+ T cell responses to achieve durable tumor immunity: comparative evaluation of IL-2, IL-15, and IL-21
about
Interleukin-21 activates human natural killer cells and modulates their surface receptor expressionInterleukin-21 is a T-helper cytokine that regulates humoral immunity and cell-mediated anti-tumour responsesDifferential effects of IL-21 and IL-15 on perforin expression, lysosomal degranulation, and proliferation in CD8 T cells of patients with human immunodeficiency virus-1 (HIV)Induced Pluripotent Stem Cell as a New Source for Cancer ImmunotherapyCytokine-Induced Modulation of Colorectal CancerImproving Adoptive T Cell Therapy: The Particular Role of T Cell Costimulation, Cytokines, and Post-Transfer VaccinationHarnessing the Microbiome to Enhance Cancer ImmunotherapyInterleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiationDual anti-OX40/IL-2 therapy augments tumor immunotherapy via IL-2R-mediated regulation of OX40 expressionPreclinical safety, pharmacokinetics, and pharmacodynamics of recombinant human interleukin-21 in cynomolgus macaques (Macaca fascicularis).Neutralizations of IL-17A and IL-21 regulate regulatory T cell/T-helper 17 imbalance via T-helper 17-associated signaling pathway in immune thrombocytopenia.Interleukin-21 induces the differentiation of human umbilical cord blood CD34-lineage- cells into pseudomature lytic NK cells.Combination of IL-21 and IL-15 enhances tumour-specific cytotoxicity and cytokine production of TCR-transduced primary T cells.T cell receptor (TCR) gene therapy to treat melanoma: lessons from clinical and preclinical studies.Recombinant interleukin-21 plus sorafenib for metastatic renal cell carcinoma: a phase 1/2 study.IL-7 and IL-21 are superior to IL-2 and IL-15 in promoting human T cell-mediated rejection of systemic lymphoma in immunodeficient mice.Human cell-based artificial antigen-presenting cells for cancer immunotherapy.Sinks, suppressors and antigen presenters: how lymphodepletion enhances T cell-mediated tumor immunotherapy.Regulating functional cell fates in CD8 T cells.Interleukin-21 is critically required in autoimmune and allogeneic responses to islet tissue in murine models.Interleukin-21 augments the efficacy of T-cell therapy by eliciting concurrent cellular and humoral responses.TGF-β enhanced IL-21-induced differentiation of human IL-21-producing CD4+ T cells via Smad3.Combined IL-21 and low-dose IL-2 therapy induces anti-tumor immunity and long-term curative effects in a murine melanoma tumor model.Reprogramming CD19-specific T cells with IL-21 signaling can improve adoptive immunotherapy of B-lineage malignancies.Elevated levels of circulating IL-7 and IL-15 in patients with early stage prostate cancer.Addition of interleukin-21 for expansion of T-cells for adoptive immunotherapy of murine melanomaMonoclonal antibody therapy of pancreatic cancer with cetuximab: potential for immune modulation.T cell immune reconstitution following lymphodepletion.Interleukins 18 and 21: biology, mechanisms of action, toxicity, and clinical activity.Interleukin-7-dependent expansion and persistence of melanoma-specific T cells in lymphodepleted mice lead to tumor regression and editing.Synergistic effects of soluble PD-1 and IL-21 on antitumor immunity against H22 murine hepatocellular carcinoma.Efficiency of CD19 chimeric antigen receptor-modified T cells for treatment of B cell malignancies in phase I clinical trials: a meta-analysisComparison of vascular leak syndrome in mice treated with IL21 or IL2Expanding roles for CD4 T cells and their subpopulations in tumor immunity and therapy.IL-21 promotes the expansion of CD27+ CD28+ tumor infiltrating lymphocytes with high cytotoxic potential and low collateral expansion of regulatory T cells.Danger signals and nonself entity of tumor antigen are both required for eliciting effective immune responses against HER-2/neu positive mammary carcinoma: implications for vaccine designRole of IL-21 in immune-regulation and tumor immunotherapy.Increased level and longevity of protective immune responses induced by DNA vaccine expressing the HIV-1 Env glycoprotein when combined with IL-21 and IL-15 gene delivery.The influence of IL-2 family cytokines on activation and function of naturally occurring regulatory T cells.The Yin and Yang of interleukin-21 in allergy, autoimmunity and cancer.
P2860
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P2860
IL-21 enhances and sustains CD8+ T cell responses to achieve durable tumor immunity: comparative evaluation of IL-2, IL-15, and IL-21
description
2004 nî lūn-bûn
@nan
2004 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
IL-21 enhances and sustains CD ...... tion of IL-2, IL-15, and IL-21
@ast
IL-21 enhances and sustains CD ...... tion of IL-2, IL-15, and IL-21
@en
IL-21 enhances and sustains CD ...... tion of IL-2, IL-15, and IL-21
@nl
type
label
IL-21 enhances and sustains CD ...... tion of IL-2, IL-15, and IL-21
@ast
IL-21 enhances and sustains CD ...... tion of IL-2, IL-15, and IL-21
@en
IL-21 enhances and sustains CD ...... tion of IL-2, IL-15, and IL-21
@nl
prefLabel
IL-21 enhances and sustains CD ...... tion of IL-2, IL-15, and IL-21
@ast
IL-21 enhances and sustains CD ...... tion of IL-2, IL-15, and IL-21
@en
IL-21 enhances and sustains CD ...... tion of IL-2, IL-15, and IL-21
@nl
P2093
P3181
P1476
IL-21 enhances and sustains CD ...... tion of IL-2, IL-15, and IL-21
@en
P2093
Adrianna Moroz
Cheryl Eppolito
Christopher H Clegg
Jianming Tao
Protul A Shrikant
Qingsheng Li
P3181
P356
10.4049/JIMMUNOL.173.2.900
P407
P577
2004-07-15T00:00:00Z