RAP46 is a negative regulator of glucocorticoid receptor action and hormone-induced apoptosis
about
An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulatorsReceptor interacting protein RIP140 inhibits both positive and negative gene regulation by glucocorticoidsAtBAG6, a novel calmodulin-binding protein, induces programmed cell death in yeast and plantsShort peptides derived from the BAG-1 C-terminus inhibit the interaction between BAG-1 and HSC70 and decrease breast cancer cell growthBiological activities of HAP46/BAG-1. The HAP46/BAG-1 protein: regulator of HSP70 chaperones, DNA-binding protein and stimulator of transcription.Hsp70-RAP46 interaction in downregulation of DNA binding by glucocorticoid receptorThe cochaperone Bag-1L enhances androgen receptor action via interaction with the NH2-terminal region of the receptorHuman BAG-1 proteins bind to the cellular stress response protein GADD34 and interfere with GADD34 functionsA nuclear action of the eukaryotic cochaperone RAP46 in downregulation of glucocorticoid receptor activityRole of Nuclear Receptors in Central Nervous System Development and Associated DiseasesThe ubiquitin-related BAG-1 provides a link between the molecular chaperones Hsc70/Hsp70 and the proteasomeBAG1L enhances trans-activation function of the vitamin D receptorMolecular chaperone targeting and regulation by BAG family proteinsIdentification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arraysBAG-i expression in human breast cancer: interrelationship between BAG-1 RNA, protein, HSC70 expression and clinico-pathological data.Dissection of the ATP-binding domain of the chaperone hsc70 for interaction with the cofactor Hap46.Maturation of steroid receptors: an example of functional cooperation among molecular chaperones and their associated proteinsDrosophila starvin encodes a tissue-specific BAG-domain protein required for larval food uptake.The hsp70-associating protein Hap46 binds to DNA and stimulates transcriptionBAG-1--a nucleotide exchange factor of Hsc70 with multiple cellular functions.The molecular basis for the effectiveness, toxicity, and resistance to glucocorticoids: focus on the treatment of rheumatoid arthritis.High level expression of differentially localized BAG-1 isoforms in some oestrogen receptor-positive human breast cancers.Dysregulation of glucocorticoid receptor co-factors FKBP5, BAG1 and PTGES3 in prefrontal cortex in psychotic illness.Multiple, but concerted cellular activities of the human protein Hap46/BAG-1M and isoforms.Different BAG-1 isoforms have distinct functions in modulating chemotherapeutic-induced apoptosis in breast cancer cells.Translational profiling of stress-induced neuroplasticity in the CA3 pyramidal neurons of BDNF Val66Met mice.The p27-Skp2 axis mediates glucocorticoid-induced cell cycle arrest in T-lymphoma cells.BAG-1 diversely affects steroid receptor activity.Interference between proteins Hap46 and Hop/p60, which bind to different domains of the molecular chaperone hsp70/hsc70.Transcriptional stimulation by the DNA binding protein Hap46/BAG-1M involves hsp70/hsc70 molecular chaperones.Distinct BAG-1 isoforms have different anti-apoptotic functions in BAG-1-transfected C33A human cervical carcinoma cell line.Distinct isoforms of the cofactor BAG-1 differentially affect Hsc70 chaperone function.Differential effects of the hsp70-binding protein BAG-1 on glucocorticoid receptor folding by the hsp90-based chaperone machinery.BAG-1 accelerates cell motility of human gastric cancer cells.Transcriptional repression of the 5-HT1A receptor promoter by corticosterone via mineralocorticoid receptors depends on the cellular context.Hsp70 cochaperones HspBP1 and BAG-1M differentially regulate steroid hormone receptor function.BAG-1, a negative regulator of Hsp70 chaperone activity, uncouples nucleotide hydrolysis from substrate release.Expression profiling of glucocorticoid-treated T-ALL cell lines: rapid repression of multiple genes involved in RNA-, protein- and nucleotide synthesis.Apoptosis inhibition mediated by medroxyprogesterone acetate treatment of breast cancer cell lines.Essential role of the unusual DNA-binding motif of BAG-1 for inhibition of the glucocorticoid receptor.
P2860
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P2860
RAP46 is a negative regulator of glucocorticoid receptor action and hormone-induced apoptosis
description
1998 nî lūn-bûn
@nan
1998 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
RAP46 is a negative regulator ...... and hormone-induced apoptosis
@ast
RAP46 is a negative regulator ...... and hormone-induced apoptosis
@en
RAP46 is a negative regulator ...... and hormone-induced apoptosis
@nl
type
label
RAP46 is a negative regulator ...... and hormone-induced apoptosis
@ast
RAP46 is a negative regulator ...... and hormone-induced apoptosis
@en
RAP46 is a negative regulator ...... and hormone-induced apoptosis
@nl
prefLabel
RAP46 is a negative regulator ...... and hormone-induced apoptosis
@ast
RAP46 is a negative regulator ...... and hormone-induced apoptosis
@en
RAP46 is a negative regulator ...... and hormone-induced apoptosis
@nl
P2093
P2860
P356
P1476
RAP46 is a negative regulator ...... and hormone-induced apoptosis
@en
P2093
P2860
P304
14620-14625
P356
10.1074/JBC.273.23.14620
P407
P50
P577
1998-06-01T00:00:00Z