Human Kruppel-like factor 5 is a target of the E3 ubiquitin ligase WWP1 for proteolysis in epithelial cells
about
Proteasomal degradation of the KLF5 transcription factor through a ubiquitin-independent pathwayWW domain containing E3 ubiquitin protein ligase 1 targets the full-length ErbB4 for ubiquitin-mediated degradation in breast cancerOestrogen causes ATBF1 protein degradation through the oestrogen-responsive E3 ubiquitin ligase EFPMammalian Krüppel-like factors in health and diseasesRegulation of p53 localization and transcription by the HECT domain E3 ligase WWP1Evasion of anti-growth signaling: A key step in tumorigenesis and potential target for treatment and prophylaxis by natural compounds.FBW7-mediated ubiquitination and degradation of KLF5The double life of KLF5: Opposing roles in regulation of gene-expression, cellular function, and transformationUbiquitin E3 ligase WWP1 as an oncogenic factor in human prostate cancerKLF5 inhibits angiogenesis in PTEN-deficient prostate cancer by attenuating AKT activation and subsequent HIF1α accumulationEzrin ubiquitylation by the E3 ubiquitin ligase, WWP1, and consequent regulation of hepatocyte growth factor receptor activityKrüppel-like factor 11 regulates the expression of metabolic genes via an evolutionarily conserved protein interaction domain functionally disrupted in maturity onset diabetes of the young.The Fbw7/human CDC4 tumor suppressor targets proproliferative factor KLF5 for ubiquitination and degradation through multiple phosphodegron motifs.ATBF1 inhibits estrogen receptor (ER) function by selectively competing with AIB1 for binding to the ER in ER-positive breast cancer cells.Curcumin promotes KLF5 proteasome degradation through downregulating YAP/TAZ in bladder cancer cells.WWOX suppresses KLF5 expression and breast cancer cell growthUbiquitin becomes ubiquitous in cancer: emerging roles of ubiquitin ligases and deubiquitinases in tumorigenesis and as therapeutic targets.Different expression patterns and functions of acetylated and unacetylated Klf5 in the proliferation and differentiation of prostatic epithelial cells.Differential regulation of dendritic and axonal development by the novel Krüppel-like factor Dar1Identification of poly (ADP-ribose) polymerase-1 (PARP-1) as a novel Kruppel-like factor 8-interacting and -regulating proteinA Krüppel-like factor downstream of the E3 ligase WWP-1 mediates dietary-restriction-induced longevity in Caenorhabditis elegans.WW domain-containing E3 ubiquitin protein ligase 1 (WWP1) delays cellular senescence by promoting p27(Kip1) degradation in human diploid fibroblasts.The E3 ubiquitin ligase SMAD ubiquitination regulatory factor 2 negatively regulates Krüppel-like factor 5 protein.Ataxin-3 like (ATXN3L), a member of the Josephin family of deubiquitinating enzymes, promotes breast cancer proliferation by deubiquitinating Krüppel-like factor 5 (KLF5).Roles of Klf5 Acetylation in the Self-Renewal and the Differentiation of Mouse Embryonic Stem Cells.BAP1 promotes breast cancer cell proliferation and metastasis by deubiquitinating KLF5.Functional Characterization of a WWP1/Tiul1 Tumor-derived Mutant Reveals a Paradigm of Its Constitutive Activation in Human Cancer.Fbw7γ-mediated degradation of KLF13 prevents RANTES expression in resting human but not murine T lymphocytes.The ubiquitin E3 ligase WWP1 decreases CXCL12-mediated MDA231 breast cancer cell migration and bone metastasis.The interplay between TEAD4 and KLF5 promotes breast cancer partially through inhibiting the transcription of p27Kip1.Cardiomyocyte-specific overexpression of the ubiquitin ligase Wwp1 contributes to reduction in Connexin 43 and arrhythmogenesis.Coping with stress: multiple ways to activate p53.Oestrogen causes degradation of KLF5 by inducing the E3 ubiquitin ligase EFP in ER-positive breast cancer cells.Ubiquitin E3 ligase Wwp1 negatively regulates osteoblast function by inhibiting osteoblast differentiation and migrationAcetylation of KLF5 alters the assembly of p15 transcription factors in transforming growth factor-beta-mediated induction in epithelial cells.Feeder-free derivation of induced pluripotent stem cells from adult human adipose stem cellsThe role of Krüppel-like factors in the reprogramming of somatic cells to induced pluripotent stem cells.Estrogen-induced interaction between KLF5 and estrogen receptor (ER) suppresses the function of ER in ER-positive breast cancer cellsCharacterization and phylogenetic analysis of Krüppel-like transcription factor (KLF) gene family in tree shrews (Tupaia belangeri chinensis).Smurf control in bone cells.
P2860
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P2860
Human Kruppel-like factor 5 is a target of the E3 ubiquitin ligase WWP1 for proteolysis in epithelial cells
description
2005 nî lūn-bûn
@nan
2005 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Human Kruppel-like factor 5 is ...... roteolysis in epithelial cells
@ast
Human Kruppel-like factor 5 is ...... roteolysis in epithelial cells
@en
Human Kruppel-like factor 5 is ...... roteolysis in epithelial cells
@nl
type
label
Human Kruppel-like factor 5 is ...... roteolysis in epithelial cells
@ast
Human Kruppel-like factor 5 is ...... roteolysis in epithelial cells
@en
Human Kruppel-like factor 5 is ...... roteolysis in epithelial cells
@nl
prefLabel
Human Kruppel-like factor 5 is ...... roteolysis in epithelial cells
@ast
Human Kruppel-like factor 5 is ...... roteolysis in epithelial cells
@en
Human Kruppel-like factor 5 is ...... roteolysis in epithelial cells
@nl
P2093
P2860
P50
P356
P1476
Human Kruppel-like factor 5 is ...... roteolysis in epithelial cells
@en
P2093
Jerry B Lingrel
Jonathan W Simons
Junxiu Ling
Pooja Sethi
Xiaohong Cheng
P2860
P304
P356
10.1074/JBC.M506183200
P407
P577
2005-12-16T00:00:00Z