Disruption of ceruloplasmin and hephaestin in mice causes retinal iron overload and retinal degeneration with features of age-related macular degeneration
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Neurodegeneration with brain iron accumulation: update on pathogenic mechanismsRetinal iron homeostasis in health and diseaseThe amyloid precursor protein (APP) does not have a ferroxidase site in its E2 domainTowards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examplesHuman hephaestin expression is not limited to enterocytes of the gastrointestinal tract but is also found in the antrum, the enteric nervous system, and pancreatic {beta}-cellsIdentification of zyklopen, a new member of the vertebrate multicopper ferroxidase family, and characterization in rodents and human cellsMechanisms and regulation of iron trafficking across the capillary endothelial cells of the blood-brain barrierMulti-copper oxidases and human iron metabolismAnimal models of age related macular degenerationRPE necroptosis in response to oxidative stress and in AMDIron homeostasis and toxicity in retinal degenerationIron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseasesAge-dependent retinal iron accumulation and degeneration in hepcidin knockout miceBmp6 regulates retinal iron homeostasis and has altered expression in age-related macular degenerationDrusen, choroidal neovascularization, and retinal pigment epithelium dysfunction in SOD1-deficient mice: a model of age-related macular degenerationBrain and retinal ferroportin 1 dysregulation in polycythaemia miceThe Project MACULA Retinal Pigment Epithelium Grading System for Histology and Optical Coherence Tomography in Age-Related Macular DegenerationMacular degeneration: recent advances and therapeutic opportunities.Chronic cigarette smoke causes oxidative damage and apoptosis to retinal pigmented epithelial cells in mice.Animals as models of age-related macular degeneration: an imperfect measure of the truth.Animal models of choroidal and retinal neovascularization.Development of choroidal neovascularization in rats with advanced intense cyclic light-induced retinal degenerationNovel rodent models for macular researchDeletion of hemojuvelin, an iron-regulatory protein, in mice results in abnormal angiogenesis and vasculogenesis in retina along with reactive gliosis.Retinal ultrastructure of murine models of dry age-related macular degeneration (AMD).Aceruloplasminemia: retinal histopathologic manifestations and iron-mediated melanosome degradationThe oral iron chelator deferiprone protects against systemic iron overload-induced retinal degeneration in hepcidin knockout mice.The retinal pigment epithelium in health and diseaseIron, the retina and the lens: a focused review.Intracellular iron transport and storage: from molecular mechanisms to health implications.Iron overload in diabetic retinopathy: a cause or a consequence of impaired mechanisms?Microarray analysis of murine retinal light damage reveals changes in iron regulatory, complement, and antioxidant genes in the neurosensory retina and isolated RPE.L-ferritin binding to scara5: a new iron traffic pathway potentially implicated in retinopathy.The oral iron chelator deferiprone protects against iron overload-induced retinal degenerationAn X chromosome association scan of the Norfolk Island genetic isolate provides evidence for a novel migraine susceptibility locus at Xq12.Histologic basis of variations in retinal pigment epithelium autofluorescence in eyes with geographic atrophy.Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMDIron increases APP translation and amyloid-beta production in the retina.Role of heme in cardiovascular physiology and disease.Ferritin overexpression in Drosophila glia leads to iron deposition in the optic lobes and late-onset behavioral defects.
P2860
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P2860
Disruption of ceruloplasmin and hephaestin in mice causes retinal iron overload and retinal degeneration with features of age-related macular degeneration
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2004 nî lūn-bûn
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2004 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
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2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Disruption of ceruloplasmin an ...... e-related macular degeneration
@ast
Disruption of ceruloplasmin an ...... e-related macular degeneration
@en
Disruption of ceruloplasmin an ...... e-related macular degeneration
@nl
type
label
Disruption of ceruloplasmin an ...... e-related macular degeneration
@ast
Disruption of ceruloplasmin an ...... e-related macular degeneration
@en
Disruption of ceruloplasmin an ...... e-related macular degeneration
@nl
prefLabel
Disruption of ceruloplasmin an ...... e-related macular degeneration
@ast
Disruption of ceruloplasmin an ...... e-related macular degeneration
@en
Disruption of ceruloplasmin an ...... e-related macular degeneration
@nl
P2093
P2860
P356
P1476
Disruption of ceruloplasmin an ...... e-related macular degeneration
@en
P2093
John Beard
Joshua L Dunaief
Tzvete Dentchev
Zena Leah Harris
P2860
P304
13850-13855
P356
10.1073/PNAS.0405146101
P407
P50
P577
2004-09-13T00:00:00Z