The tax gene of human T-cell leukemia virus type 2 is essential for transformation of human T lymphocytes
about
Highlights on distinctive structural and functional properties of HTLV Tax proteinsComparative biology of human T-cell lymphotropic virus type 1 (HTLV-1) and HTLV-2PDZ domain-binding motif of human T-cell leukemia virus type 1 Tax oncoprotein is essential for the interleukin 2 independent growth induction of a T-cell linePresence of a functional but dispensable nuclear export signal in the HTLV-2 Tax protein.Discordance between bovine leukemia virus tax immortalization in vitro and oncogenicity in vivo.HTLV-1 Rex is required for viral spread and persistence in vivo but is dispensable for cellular immortalization in vitro.Human and simian T-cell leukemia viruses type 2 (HTLV-2 and STLV-2(pan-p)) transform T cells independently of Jak/STAT activation.Walleye retroviruses associated with skin tumors and hyperplasias encode cyclin D homologs.Human T-cell leukemia virus type 2 tax mutants that selectively abrogate NFkappaB or CREB/ATF activation fail to transform primary human T cells.Differences in the ability of human T-cell lymphotropic virus type 1 (HTLV-1) and HTLV-2 tax to inhibit p53 function.Human T-cell leukemia virus type 2 Rex protein increases stability and promotes nuclear to cytoplasmic transport of gag/pol and env RNAsBovine leukemia virus structural gene vectors are immunogenic and lack pathogenicity in a rabbit model.Genetic evidence of a role for ATM in functional interaction between human T-cell leukemia virus type 1 Tax and p53.Phosphorylation of two serine residues regulates human T-cell leukemia virus type 2 Rex function.Aberrant activation of the interleukin-2 autocrine loop through the nuclear factor of activated T cells by nonleukemogenic human T-cell leukemia virus type 2 but not by leukemogenic type 1 virusInduction of cell cycle arrest by human T-cell lymphotropic virus type 1 Tax in hematopoietic progenitor (CD34+) cells: modulation of p21cip1/waf1 and p27kip1 expression.Human T-cell leukemia virus type 1 expressing nonoverlapping tax and rex genes replicates and immortalizes primary human T lymphocytes but fails to replicate and persist in vivo.Envelope is a major viral determinant of the distinct in vitro cellular transformation tropism of human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2.Oncoviral bovine leukemia virus G4 and human T-cell leukemia virus type 1 p13(II) accessory proteins interact with farnesyl pyrophosphate synthetase.Long-term infection with retroviral structural gene vector provides protection against bovine leukemia virus disease in rabbits.Integration site preference of xenotropic murine leukemia virus-related virus, a new human retrovirus associated with prostate cancer.Human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2 use different receptor complexes to enter T cells.Tax and overlapping rex sequences do not confer the distinct transformation tropisms of human T-cell leukemia virus types 1 and 2Clonality of HTLV-2 in natural infection.Human T Lymphotropic Virus Type 1 (HTLV-1): Molecular Biology and Oncogenesis.Human T-cell leukemia virus type 1 Tax oncoprotein represses the expression of the BCL11B tumor suppressor in T-cells.Enhancement of infectivity and persistence in vivo by HBZ, a natural antisense coded protein of HTLV-1.Mutational analysis of human T-cell leukemia virus type 2 Tax.The human T-cell leukemia virus Rex proteinDetection and quantitation of HTLV-1 and HTLV-2 mRNA species by real-time RT-PCR.Human T-cell leukemia virus type 2 antisense viral protein 2 is dispensable for in vitro immortalization but functions to repress early virus replication in vivo.Comparative host protein interactions with HTLV-1 p30 and HTLV-2 p28: insights into difference in pathobiology of human retroviruses.HTLV tax: a fascinating multifunctional co-regulator of viral and cellular pathwaysFunctional Comparison of HBZ and the Related APH-2 Protein Provides Insight into Human T-Cell Leukemia Virus Type 1 Pathogenesis.Human T-cell leukemia virus type 1 tax oncoprotein suppression of multilineage hematopoiesis of CD34+ cells in vitroHuman T-cell leukemia virus type-1 antisense-encoded gene, Hbz, promotes T-lymphocyte proliferation.Functional domain structure of human T-cell leukemia virus type 2 rex.Human T-cell leukemia virus type 2 Rex carboxy terminus is an inhibitory/stability domain that regulates Rex functional activity and viral replication.Site-specific phosphorylation regulates human T-cell leukemia virus type 2 Rex function in vivo.Phosphorylation regulates human T-cell leukemia virus type 1 Rex function.
P2860
Q21131117-6FE908CD-85BE-43EB-BF71-61E62102420AQ24653987-6B1897CF-A95F-4CF4-8AAC-18B089C179D6Q24811663-9C714BDA-C70B-4309-8E74-82616EE2D7D8Q24815719-D992D7B1-B1A8-4CAC-A81C-BCC283CDABC3Q33603462-22EE9EB5-3CCA-46E4-9AD6-658945C8FFB8Q33779850-66BB6926-549F-4BF6-B398-62B4244084DEQ33782891-ED04A513-2DC8-4125-A041-70281C1FB7DFQ33785258-05D3B41B-7B3B-4E2B-B0DF-D105A56B4CD8Q33799859-62726F6A-DFE6-46BC-9C99-F53B93C589B4Q33808681-C4519AFA-26E4-4CBD-BAF5-F62B55CF88D1Q33819203-A592DC4A-3FED-45F4-9989-4FDF7F29B682Q33819351-CE353FC3-0172-4C29-BAD9-19E0F74EF35EQ33834966-6EF22A16-891C-44B1-993A-C7B43694FE8EQ33854182-758439A3-B609-4004-97E1-1A4B0E9D79FFQ33987558-78291AD7-FD8D-4426-B10F-92D8CAC88C04Q34123855-F5276A3A-3F44-47A2-8666-85F8D6157EB5Q34142773-8F5B7DAD-76C6-461C-878D-716B8B9A97BCQ34142780-5731A3C1-3E8F-44E6-841D-D0A78FA232DBQ34329174-E1EA46EF-81B5-45E6-A263-E34503FB0166Q34626580-85ABA749-922B-4E1F-AAAE-95B8C45D1B6EQ34804987-F3492311-330C-4442-9526-3EA843AF4DB6Q35024063-B514C9B9-E00B-46C0-843D-107F78EB4598Q35104884-335D8AAD-0E46-4B4D-AE14-3F11BF04E8C9Q35120139-CF9DF9DA-2EF9-4324-9E52-B6B710C35F24Q35261245-C0F5C6F5-354A-4822-8FCC-11E31833CED9Q35538474-1BCCF9E9-9EEA-4F82-8E6D-00C66B10273BQ35848284-55B92B93-10B3-4A4A-B8EB-FB7D60D0A52DQ35899345-B9B4DDA4-9700-4C43-A300-CDCF1265E553Q35969160-37F8D7E2-3782-48EC-A4E0-F5FA42CA0DC7Q36103218-DA51F13A-1458-4369-859A-59AFB1979F03Q36172168-F0D0E9E5-D8C0-4C2F-9564-9EE3BE19B0ACQ36299426-989978B6-7F76-46DF-9AD1-C0AF2F34B8BEQ36434903-49B1D803-BC90-4A0E-9D3A-ECD0A57DB540Q36694078-E8B089DC-AEEF-4CAF-8415-A31CF26B8C02Q36890778-1110FDB8-0E4A-4D75-829D-15182AE5C9A7Q36948607-C198B847-8945-4728-8E2C-B50E1923069AQ37059755-DB47484E-D2B3-46D6-AB72-E601B18E0C2EQ37192222-685EAE30-E918-4ADD-BFBB-A67C7C44FE0BQ37333854-DEEC4E47-F89C-4D0E-9804-C53AB4A5E036Q37429560-ECCE5477-6C0A-4464-9A7E-8F140A19A285
P2860
The tax gene of human T-cell leukemia virus type 2 is essential for transformation of human T lymphocytes
description
1996 nî lūn-bûn
@nan
1996 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
The tax gene of human T-cell l ...... rmation of human T lymphocytes
@ast
The tax gene of human T-cell l ...... rmation of human T lymphocytes
@en
The tax gene of human T-cell l ...... rmation of human T lymphocytes
@nl
type
label
The tax gene of human T-cell l ...... rmation of human T lymphocytes
@ast
The tax gene of human T-cell l ...... rmation of human T lymphocytes
@en
The tax gene of human T-cell l ...... rmation of human T lymphocytes
@nl
prefLabel
The tax gene of human T-cell l ...... rmation of human T lymphocytes
@ast
The tax gene of human T-cell l ...... rmation of human T lymphocytes
@en
The tax gene of human T-cell l ...... rmation of human T lymphocytes
@nl
P2093
P2860
P1433
P1476
The tax gene of human T-cell l ...... rmation of human T lymphocytes
@en
P2093
S M Pettiford
P2860
P304
P407
P577
1996-08-01T00:00:00Z