RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination
about
RAG1 core and V(D)J recombination signal sequences were derived from Transib transposonsThe genome sequence of the colonial chordate, Botryllus schlosseriT cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expressionEvolution of the RAG1-RAG2 locus: both proteins came from the same transposonA novel testis-specific RAG2-like protein, Peas: its expression in pachytene spermatocyte cytoplasm and meiotic chromatinThe RAG1 N-terminal domain is an E3 ubiquitin ligaseAmino acid residues in RAG1 responsible for the interaction with RAG2 during the V(D)J recombination processRch1, a protein that specifically interacts with the RAG-1 recombination-activating proteinRAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1DNA binding of Xrcc4 protein is associated with V(D)J recombination but not with stimulation of DNA ligase IV activityThe gene for severe combined immunodeficiency disease in Athabascan-speaking Native Americans is located on chromosome 10p.Medical immunology: a new journal for a new subspecialty.Evidence against T-cell development in the adult human intestinal mucosa based upon lack of terminal deoxynucleotidyltransferase expressionAn ancient evolutionary origin of the Rag1/2 gene locusNonhomologous end joining and V(D)J recombination require an additional factorThe RAG1 homeodomain recruits HMG1 and HMG2 to facilitate recombination signal sequence binding and to enhance the intrinsic DNA-bending activity of RAG1-RAG2Functional and biochemical dissection of the structure-specific nuclease ARTEMISTargeted oncogene activation by site-specific recombination in transgenic miceOrigin and evolution of the adaptive immune system: genetic events and selective pressuresThe lymphoid transcription factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros geneA combinatorial approach to create artificial homing endonucleases cleaving chosen sequencesFrom lymphocytes to sharks: V(D)J recombinase moves to the germlineThe recombination activation gene 1 (Rag1) is expressed in a subset of zebrafish olfactory neurons but is not essential for axon targeting or amino acid detection.The pre-B cell receptor; selecting for or against autoreactivityMolecular Mechanism of V(D)J Recombination from Synaptic RAG1-RAG2 Complex Structures.Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsisMolecular basis of engineered meganuclease targeting of the endogenous human RAG1 locusZebrafish Models of Human Leukemia: Technological Advances and Mechanistic InsightsKu70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombinationThe XRCC4 gene product is a target for and interacts with the DNA-dependent protein kinaseMechanistic constraints on diversity in human V(D)J recombinationMolluscan mobile elements similar to the vertebrate Recombination-Activating GenesHuman RAG mutations: biochemistry and clinical implicationsSingle-strand recombination signal sequence nicks in vivo: evidence for a capture model of synapsisDNA-dependent kinase (p350) as a candidate gene for the murine SCID defectDefective nonhomologous end joining blocks B-cell development in FLT3/ITD miceDNA polymerase theta contributes to the generation of C/G mutations during somatic hypermutation of Ig genes.Expression and V(D)J recombination activity of mutated RAG-1 proteinsAutoubiquitylation of the V(D)J recombinase protein RAG1Compound heterozygous mutation of Rag1 leading to Omenn syndrome
P2860
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P2860
RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination
description
1990 nî lūn-bûn
@nan
1990 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1990 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
name
RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination
@ast
RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination
@en
RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination
@nl
type
label
RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination
@ast
RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination
@en
RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination
@nl
prefLabel
RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination
@ast
RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination
@en
RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination
@nl
P2093
P3181
P356
P1433
P1476
RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination
@en
P2093
D Baltimore
D G Schatz
M A Oettinger
P304
P3181
P356
10.1126/SCIENCE.2360047
P407
P577
1990-06-22T00:00:00Z