Binding interactions of human interleukin 5 with its receptor alpha subunit. Large scale production, structural, and functional studies of Drosophila-expressed recombinant proteins
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Role of biologics in severe eosinophilic asthma - focus on reslizumabA potent dimeric peptide antagonist of interleukin-5 that binds two interleukin-5 receptor alpha chainsReceptor epitope usage by an interleukin-5 mimetic peptide.Asymmetric usage of antagonist charged residues drives interleukin-5 receptor recruitment but is insufficient for receptor activationThe insect metalloproteinase inhibitor gene of the lepidopteran Galleria mellonella encodes two distinct inhibitors.Instrumental biosensors: new perspectives for the analysis of biomolecular interactions.The use of biosensor technology for the engineering of antibodies and enzymes.Mutagenesis in the C-terminal region of human interleukin 5 reveals a central patch for receptor alpha chain recognition.A baculovirus superinfection system: efficient vehicle for gene transfer into Drosophila S2 cells.Interleukin-5, a therapeutic target in allergic inflammationThe GM-CSF/IL-3/IL-5 cytokine receptor family: from ligand recognition to initiation of signaling.Slow, reversible, coupled folding and binding of the spectrin tetramerization domain.Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL.Monomeric isomers of human interleukin 5 show that 1:1 receptor recruitment is sufficient for functionInterleukin-5 receptor subunit oligomerization and rearrangement revealed by fluorescence resonance energy transfer imagingStructural genomics and drug discovery.Characterization of potential antagonists of human interleukin 5 demonstrates their cross-reactivity with receptors for interleukin 3 and granulocyte-macrophage colony-stimulating factor.Expression of recombinant Atlantic salmon serum C-type lectin in Drosophila melanogaster Schneider 2 cells.Human airway eosinophils exhibit preferential reduction in STAT signaling capacity and increased CISH expression.Molecular and clinical rationale for therapeutic targeting of interleukin-5 and its receptor.Expression and in vitro properties of guinea pig IL-5: comparison to human and murine orthologs.Genetic encoding of non-natural amino acids in Drosophila melanogaster Schneider 2 cells.Protein expression in the Drosophila Schneider 2 cell system.Molecular interaction analysis in ligand design using mass transport, kinetic and thermodynamic methods.Single chain human interleukin 5 and its asymmetric mutagenesis for mapping receptor binding sites.ST2/T1 protein functionally binds to two secreted proteins from Balb/c 3T3 and human umbilical vein endothelial cells but does not bind interleukin 1.A biosensor study indicating that entropy, electrostatics, and receptor glycosylation drive the binding interaction between interleukin-7 and its receptor.Interleukin 5 interactions with soluble and cell surface forms of its receptor.Evidence for the formation of a heterotrimeric complex of leukaemia inhibitory factor with its receptor subunits in solutionMutants of single chain interleukin 5 show asymmetric recruitment of receptor alpha and betac subunits.Severe eosinophilic asthma: from the pathogenic role of interleukin-5 to the therapeutic action of mepolizumab.Protein design: on the threshold of functional properties.Kinetic interaction analysis of human interleukin 5 receptor alpha mutants reveals a unique binding topology and charge distribution for cytokine recognition.Epitope randomization redefines the functional role of glutamic acid 110 in interleukin-5 receptor activation.The Heparan Sulfate Binding Sequence of Interferon-γ Increased the On Rate of the Interferon-γ-Interferon-γ Receptor Complex FormationSpatial Orientation of the α and βcReceptor Chain Binding Sites on Monomeric Human Interleukin-5 ConstructsDevelopment of prolactin receptor antagonists with reduced pH-dependence of receptor binding
P2860
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P2860
Binding interactions of human interleukin 5 with its receptor alpha subunit. Large scale production, structural, and functional studies of Drosophila-expressed recombinant proteins
description
1995 nî lūn-bûn
@nan
1995 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Binding interactions of human ...... expressed recombinant proteins
@ast
Binding interactions of human ...... expressed recombinant proteins
@en
Binding interactions of human ...... expressed recombinant proteins
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type
label
Binding interactions of human ...... expressed recombinant proteins
@ast
Binding interactions of human ...... expressed recombinant proteins
@en
Binding interactions of human ...... expressed recombinant proteins
@nl
prefLabel
Binding interactions of human ...... expressed recombinant proteins
@ast
Binding interactions of human ...... expressed recombinant proteins
@en
Binding interactions of human ...... expressed recombinant proteins
@nl
P2093
P2860
P3181
P356
P1476
Binding interactions of human ...... expressed recombinant proteins
@en
P2093
E Appelbaum
K Johanson
S S Abdel-Meguid
P2860
P304
P3181
P356
10.1074/JBC.270.16.9459
P407
P577
1995-04-21T00:00:00Z