Direct association of Grb2 with the p85 subunit of phosphatidylinositol 3-kinase
about
p62, a phosphotyrosine-independent ligand of the SH2 domain of p56lck, belongs to a new class of ubiquitin-binding proteinsGrap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathwayGrowth factor receptor-bound protein 2 SH2/SH3 domain binding to CD28 and its role in co-signalingErbB-1 and ErbB-2 acquire distinct signaling properties dependent upon their dimerization partner.Negative regulation of PI 3-kinase by Ruk, a novel adaptor proteinPhosphoinositides: tiny lipids with giant impact on cell regulationBrain-derived neurotrophic factor stimulates interactions of Shp2 with phosphatidylinositol 3-kinase and Grb2 in cultured cerebral cortical neuronsHyaluronan promotes CD44v3-Vav2 interaction with Grb2-p185(HER2) and induces Rac1 and Ras signaling during ovarian tumor cell migration and growthLAT, the linker for activation of T cells: a bridge between T cell-specific and general signaling pathwaysThe platelet-derived growth factor beta receptor triggers multiple cytoplasmic signaling cascades that arrive at the nucleus as distinguishable inputsEpidermal growth factor-induced phosphatidylinositol 3-kinase activation and DNA synthesis. Identification of Grb2-associated binder 2 as the major mediator in rat hepatocytesARIA/HRG regulates AChR epsilon subunit gene expression at the neuromuscular synapse via activation of phosphatidylinositol 3-kinase and Ras/MAPK pathwayNew role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathwayTyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of phosphatidylinositol 3-kinase and AktTGF-β2 induces Grb2 to recruit PI3-K to TGF-RII that activates JNK/AP-1-signaling and augments invasiveness of Theileria-transformed macrophages.Regulation of the PI3K pathway through a p85α monomer-homodimer equilibriumgrb2 heterozygosity rescues embryonic lethality but not tumorigenesis in pten+/- mice.A new tyrosine-phosphorylated 97-kDa adaptor protein mediates interleukin-2-induced association of SHP-2 with p85-phosphatidylinositol 3-kinase in human T lymphocytes.Shrinkage-induced protein tyrosine phosphorylation in Chinese hamster ovary cells.Activation of the JNK pathway is essential for transformation by the Met oncogeneSignaling inositol polyphosphate-5-phosphatase. Characterization of activity and effect of GRB2 association.Association between receptor protein-tyrosine phosphatase RPTPalpha and the Grb2 adaptor. Dual Src homology (SH) 2/SH3 domain requirement and functional consequences.Regulation of colony-stimulating factor 1 receptor signaling by the SH2 domain-containing tyrosine phosphatase SHPTP1Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of phosphatidylinositol 3-kinase in muscle and brain.In brain, Axl recruits Grb2 and the p85 regulatory subunit of PI3 kinase; in vitro mutagenesis defines the requisite binding sites for downstream Akt activation.Genetic or pharmaceutical blockade of phosphoinositide 3-kinase p110δ prevents chronic rejection of heart allograftsA human class II MHC-derived peptide antagonizes phosphatidylinositol 3-kinase to block IL-2 signaling.JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis.Platelet-derived growth factor-dependent activation of phosphatidylinositol 3-kinase is regulated by receptor binding of SH2-domain-containing proteins which influence Ras activityInsulin-like growth factor-I stimulates Shc-dependent phosphatidylinositol 3-kinase activation via Grb2-associated p85 in vascular smooth muscle cellsSignal transduction pathways that contribute to myeloid differentiation.Ligand-induced EpoR internalization is mediated by JAK2 and p85 and is impaired by mutations responsible for primary familial and congenital polycythemiaDiscovery of a novel target for cancer: PRR14Multiple roles for the p85α isoform in the regulation and function of PI3K signalling and receptor trafficking.Liposomal delivery of nucleic acid-based anticancer therapeutics: BP-100-1.01.DNAM-1 controls NK cell activation via an ITT-like motif.The role of PI 3-kinase in the UVB-induced expression of c-fos.CD28: a signalling perspective.A coiled-coil tetramerization domain of BCR-ABL is essential for the interactions of SH2-containing signal transduction molecules.Signal characteristics of G protein-transactivated EGF receptor.
P2860
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P2860
Direct association of Grb2 with the p85 subunit of phosphatidylinositol 3-kinase
description
1995 nî lūn-bûn
@nan
1995 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Direct association of Grb2 with the p85 subunit of phosphatidylinositol 3-kinase
@ast
Direct association of Grb2 with the p85 subunit of phosphatidylinositol 3-kinase
@en
Direct association of Grb2 with the p85 subunit of phosphatidylinositol 3-kinase
@nl
type
label
Direct association of Grb2 with the p85 subunit of phosphatidylinositol 3-kinase
@ast
Direct association of Grb2 with the p85 subunit of phosphatidylinositol 3-kinase
@en
Direct association of Grb2 with the p85 subunit of phosphatidylinositol 3-kinase
@nl
prefLabel
Direct association of Grb2 with the p85 subunit of phosphatidylinositol 3-kinase
@ast
Direct association of Grb2 with the p85 subunit of phosphatidylinositol 3-kinase
@en
Direct association of Grb2 with the p85 subunit of phosphatidylinositol 3-kinase
@nl
P2093
P2860
P356
P1476
Direct association of Grb2 with the p85 subunit of phosphatidylinositol 3-kinase
@en
P2093
P2860
P304
P356
10.1074/JBC.270.21.12774
P407
P577
1995-05-26T00:00:00Z