Retinoid-related orphan receptor gamma t is a potential therapeutic target for controlling inflammatory autoimmunity
about
The therapeutic potential of RORγ modulators in the treatment of human diseaseIdentification of Tetraazacyclic Compounds as Novel Potent Inhibitors Antagonizing RORγt Activity and Suppressing Th17 Cell DifferentiationIdentification of an allosteric binding site for RORγt inhibition.Critical role of TCF-1 in repression of the IL-17 gene.The Th17-defining transcription factor RORγt promotes glomerulonephritisRetinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolismIdentification of a novel non-retinoid pan inverse agonist of the retinoic acid receptorsPharmacologic repression of retinoic acid receptor-related orphan nuclear receptor γ is therapeutic in the collagen-induced arthritis experimental model.T-cell phenotypes in chronic rhinosinusitis with nasal polyps in Japanese patients.Inflammatory T helper 17 cells promote depression-like behavior in mice.Digoxin reduces atherosclerosis in apolipoprotein E-deficient miceEgr3 induces a Th17 response by promoting the development of γδ T cells.Synthetic RORγt Agonists Enhance Protective Immunity.The interplay between retinoic acid receptor-related orphan receptors and human diseases.Cytokine control of inflammation and repair in the pathology of multiple sclerosis.Discovery of Tertiary Amine and Indole Derivatives as Potent RORγt Inverse Agonists.RAR-Related Orphan Receptor Gamma (ROR-γ) Mediates Epithelial-Mesenchymal Transition Of Hepatocytes During Hepatic Fibrosis.Protein kinase C-θ inhibits inducible regulatory T cell differentiation via an AKT-Foxo1/3a-dependent pathway.Protein kinase C-θ promotes Th17 differentiation via upregulation of Stat3.Intervention of PKC-θ as an immunosuppressive regimen.Ubiquitination of RORγt at Lysine 446 Limits Th17 Differentiation by Controlling Coactivator Recruitment.Regulation of Th17 Differentiation by IKKα-Dependent and -Independent Phosphorylation of RORγt.A two-amino-acid substitution in the transcription factor RORγt disrupts its function in TH17 differentiation but not in thymocyte development.Impaired balance of Th17/Treg in patients with nasal polyposis.Absence of IL-23p19 in donor allogeneic cells reduces mortality from acute GVHD.Sumoylation of RORγt regulates T17 differentiation and thymocyte development
P2860
Q27022108-29140F39-C4FC-48D3-8509-59458AEE7976Q28547983-26E37695-1B5A-460B-BF02-FCE3CF3D7501Q30394306-5697072E-C329-472B-9CC6-6F3D2E697CB0Q34026243-C970A690-F4A5-4AAF-85F4-F7EE48676C21Q34695374-A4EBD7E5-A649-4F8D-8C65-9CA28F6B5A62Q34976906-D5C69FBB-0CC5-4EF3-AE21-31CBCB9E1008Q35053371-F669629F-BE28-4A83-97F8-B452E101B41CQ35760186-061ED1A9-E1DE-4BC7-AEF2-ADB4767253DAQ36301719-2E709273-DE8C-48E7-A66A-8330F39E85E1Q36640233-A08D2E85-CEEB-490F-AEB2-4AF038208F23Q36797363-6A3C16A8-19F3-4943-B2FF-16F0A0A68A1AQ37514604-F8469E67-67F0-453F-A5D8-B18592E8F21AQ37526761-49135B1A-534C-45F1-B85E-DD7ABC86F9A7Q38017696-78B68FFC-E1C5-4459-BE8D-074F1C3B5E3DQ38067389-4E4B1658-DD0E-48F0-8330-BF12094C2389Q39786919-DD4DB643-A94A-4036-93E2-D5D89EEC239DQ40507704-421D6081-F69B-4B7C-9C7E-DA307B1050E1Q41613842-C4F81C8A-87C7-4508-A9A1-1D1BBFFA399DQ41613948-785AF3AA-5E89-42E2-9B91-555305E7AD32Q41890374-A56CAC83-D1CE-4FE5-B61B-217737D07D0AQ42376373-A3FB4B28-058A-41E5-B23B-7280E26C6176Q43523326-9508E0F9-2D90-4BC6-A10D-FEE3843044E7Q46075995-F5095F83-F5A4-4187-9C51-149A89B3991AQ52608727-C5B1301C-F734-4358-B142-5571D37E9B5BQ54628324-B1413DE8-E023-4D45-89ED-C49C6A70A7B7Q59125265-D7E21EFE-9B3C-44AC-BCCE-CC5205B0A47A
P2860
Retinoid-related orphan receptor gamma t is a potential therapeutic target for controlling inflammatory autoimmunity
description
2007 nî lūn-bûn
@nan
2007 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Retinoid-related orphan recept ...... ling inflammatory autoimmunity
@ast
Retinoid-related orphan recept ...... ling inflammatory autoimmunity
@en
Retinoid-related orphan recept ...... ling inflammatory autoimmunity
@nl
type
label
Retinoid-related orphan recept ...... ling inflammatory autoimmunity
@ast
Retinoid-related orphan recept ...... ling inflammatory autoimmunity
@en
Retinoid-related orphan recept ...... ling inflammatory autoimmunity
@nl
prefLabel
Retinoid-related orphan recept ...... ling inflammatory autoimmunity
@ast
Retinoid-related orphan recept ...... ling inflammatory autoimmunity
@en
Retinoid-related orphan recept ...... ling inflammatory autoimmunity
@nl
P2093
P2860
P1476
Retinoid-related orphan recept ...... ling inflammatory autoimmunity
@en
P2093
Huimin Xie
Ruiqing Wang
Zhaofeng Huang
Zuoming Sun
P2860
P304
P356
10.1517/14728222.11.6.737
P407
P577
2007-06-01T00:00:00Z