Retinoid-related orphan receptor gamma t is a potential therapeutic target for controlling inflammatory autoimmunity - Test2 - elhamkhani - TriplyDB

Retinoid-related orphan receptor gamma t is a potential therapeutic target for controlling inflammatory autoimmunity

Retinoid-related orphan receptor gamma t is a potential therapeutic target for controlling inflammatory autoimmunity

http://www.wikidata.org/entity/Q28302355

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The therapeutic potential of RORγ modulators in the treatment of human disease Identification of Tetraazacyclic Compounds as Novel Potent Inhibitors Antagonizing RORγt Activity and Suppressing Th17 Cell Differentiation Identification of an allosteric binding site for RORγt inhibition.Critical role of TCF-1 in repression of the IL-17 gene.The Th17-defining transcription factor RORγt promotes glomerulonephritis Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism Identification of a novel non-retinoid pan inverse agonist of the retinoic acid receptors Pharmacologic repression of retinoic acid receptor-related orphan nuclear receptor γ is therapeutic in the collagen-induced arthritis experimental model.T-cell phenotypes in chronic rhinosinusitis with nasal polyps in Japanese patients.Inflammatory T helper 17 cells promote depression-like behavior in mice.Digoxin reduces atherosclerosis in apolipoprotein E-deficient mice Egr3 induces a Th17 response by promoting the development of γδ T cells.Synthetic RORγt Agonists Enhance Protective Immunity.The interplay between retinoic acid receptor-related orphan receptors and human diseases.Cytokine control of inflammation and repair in the pathology of multiple sclerosis.Discovery of Tertiary Amine and Indole Derivatives as Potent RORγt Inverse Agonists.RAR-Related Orphan Receptor Gamma (ROR-γ) Mediates Epithelial-Mesenchymal Transition Of Hepatocytes During Hepatic Fibrosis.Protein kinase C-θ inhibits inducible regulatory T cell differentiation via an AKT-Foxo1/3a-dependent pathway.Protein kinase C-θ promotes Th17 differentiation via upregulation of Stat3.Intervention of PKC-θ as an immunosuppressive regimen.Ubiquitination of RORγt at Lysine 446 Limits Th17 Differentiation by Controlling Coactivator Recruitment.Regulation of Th17 Differentiation by IKKα-Dependent and -Independent Phosphorylation of RORγt.A two-amino-acid substitution in the transcription factor RORγt disrupts its function in TH17 differentiation but not in thymocyte development.Impaired balance of Th17/Treg in patients with nasal polyposis.Absence of IL-23p19 in donor allogeneic cells reduces mortality from acute GVHD.Sumoylation of RORγt regulates T17 differentiation and thymocyte development

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P2860

Retinoid-related orphan receptor gamma t is a potential therapeutic target for controlling inflammatory autoimmunity

http://www.wikidata.org/entity/Q28302355

description

2007 nî lūn-bûn

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2007 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2007 թվականի հունիսին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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name

Retinoid-related orphan recept ...... ling inflammatory autoimmunity

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Retinoid-related orphan recept ...... ling inflammatory autoimmunity

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Retinoid-related orphan recept ...... ling inflammatory autoimmunity

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type

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Retinoid-related orphan recept ...... ling inflammatory autoimmunity

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Retinoid-related orphan recept ...... ling inflammatory autoimmunity

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Retinoid-related orphan recept ...... ling inflammatory autoimmunity

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prefLabel

Retinoid-related orphan recept ...... ling inflammatory autoimmunity

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Retinoid-related orphan recept ...... ling inflammatory autoimmunity

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Retinoid-related orphan recept ...... ling inflammatory autoimmunity

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14728222.11.6.737

P1433

Expert Opinion on Therapeutic Targets

P1476

Retinoid-related orphan recept ...... ling inflammatory autoimmunity

@en

P2093

Huimin Xie

http://www.w3.org/2001/XMLSchema#string

Ruiqing Wang

http://www.w3.org/2001/XMLSchema#string

Zhaofeng Huang

http://www.w3.org/2001/XMLSchema#string

Zuoming Sun

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P2860

Cloning and characterization of IL-17B and IL-17C, two new members of the IL-17 cytokine family

IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1

The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways

The role of T-cell interleukin-17 in conducting destructive arthritis: lessons from animal models.

Retinoid-related orphan receptor gamma (RORgamma) is essential for lymphoid organogenesis and controls apoptosis during thymopoiesis

RORgamma t, a novel isoform of an orphan receptor, negatively regulates Fas ligand expression and IL-2 production in T cells

Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells

A signature motif in transcriptional co-activators mediates binding to nuclear receptors

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737-43

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scholarly article

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10.1517/14728222.11.6.737

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6

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6328393

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17504012

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P921