Hot spots of retroviral integration in human CD34+ hematopoietic cells
about
Retroviral integrations in gene therapy trialsGene therapy on the moveGene therapy studies in a canine model of X-linked severe combined immunodeficiencyThe GATA1-HS2 enhancer allows persistent and position-independent expression of a β-globin transgeneEfficient reprogramming of naïve-like induced pluripotent stem cells from porcine adipose-derived stem cells with a feeder-independent and serum-free systemDifferential roles of cyclin D1 and D3 in pancreatic ductal adenocarcinoma.Retroviral integration process in the human genome: is it really non-random? A new statistical approach.Correction of murine ADAMTS13 deficiency by hematopoietic progenitor cell-mediated gene therapyPreclinical safety and efficacy of human CD34(+) cells transduced with lentiviral vector for the treatment of Wiskott-Aldrich syndrome.Transcription factor binding sites are genetic determinants of retroviral integration in the human genome.Murine leukemias with retroviral insertions at Lmo2 are predictive of the leukemias induced in SCID-X1 patients following retroviral gene therapy.Concise review: lessons learned from clinical trials of gene therapy in monogenic immunodeficiency diseases.Gene-delivery systems for iPS cell generation.Stem cell marking with promotor-deprived self-inactivating retroviral vectors does not lead to induced clonal imbalance.Insertional transformation of hematopoietic cells by self-inactivating lentiviral and gammaretroviral vectors.Genotoxic potential of lineage-specific lentivirus vectors carrying the beta-globin locus control region.Cell-intrinsic and vector-related properties cooperate to determine the incidence and consequences of insertional mutagenesis.Deciphering the code for retroviral integration target site selectionVector integration and tumorigenesis.High-definition mapping of retroviral integration sites defines the fate of allogeneic T cells after donor lymphocyte infusion.CRISPR/Cas9-Mediated Correction of the FANCD1 Gene in Primary Patient CellsGenome-wide analysis of alpharetroviral integration in human hematopoietic stem/progenitor cells.Dynamics of gene-modified progenitor cells analyzed by tracking retroviral integration sites in a human SCID-X1 gene therapy trialMethodology and software to detect viral integration site hot-spots.Ex vivo expansion of retrovirally transduced primate CD34+ cells results in overrepresentation of clones with MDS1/EVI1 insertion sites in the myeloid lineage after transplantation.The BET family of proteins targets moloney murine leukemia virus integration near transcription start sites.Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich syndrome.Lentivector integration sites in ependymal cells from a model of metachromatic leukodystrophy: non-B DNA as a new factor influencing integration.Nuclear architecture dictates HIV-1 integration site selection.Biochemical correction of X-CGD by a novel chimeric promoter regulating high levels of transgene expression in myeloid cells.Deletion of the LTR enhancer/promoter has no impact on the integration profile of MLV vectors in human hematopoietic progenitors.Medicine. A comeback for gene therapy.Integration profile of retroviral vector in gene therapy treated patients is cell-specific according to gene expression and chromatin conformation of target cellRecombinant adeno-associated virus serotype 6 efficiently transduces primary human melanocytesGenetic engineering of murine CD8+ and CD4+ T cells for preclinical adoptive immunotherapy studies.Shielding the messenger (RNA): microRNA-based anticancer therapies.Distribution of lentiviral vector integration sites in mice following therapeutic gene transfer to treat β-thalassemia.Therapeutic challenges to retinitis pigmentosa: from neuroprotection to gene therapy.No evidence for clonal selection due to lentiviral integration sites in human induced pluripotent stem cells.Cell cycle status of CD34(+) hemopoietic stem cells determines lentiviral integration in actively transcribed and development-related genes.
P2860
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P2860
Hot spots of retroviral integration in human CD34+ hematopoietic cells
description
2007 nî lūn-bûn
@nan
2007 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Hot spots of retroviral integration in human CD34+ hematopoietic cells
@ast
Hot spots of retroviral integration in human CD34+ hematopoietic cells
@en
Hot spots of retroviral integration in human CD34+ hematopoietic cells
@nl
type
label
Hot spots of retroviral integration in human CD34+ hematopoietic cells
@ast
Hot spots of retroviral integration in human CD34+ hematopoietic cells
@en
Hot spots of retroviral integration in human CD34+ hematopoietic cells
@nl
prefLabel
Hot spots of retroviral integration in human CD34+ hematopoietic cells
@ast
Hot spots of retroviral integration in human CD34+ hematopoietic cells
@en
Hot spots of retroviral integration in human CD34+ hematopoietic cells
@nl
P2093
P50
P3181
P1433
P1476
Hot spots of retroviral integration in human CD34+ hematopoietic cells
@en
P2093
Daniela Sartori
Giulia Facchini
Giuliana Ferrari
Manfred Schmidt
Steve Howe
P304
P3181
P356
10.1182/BLOOD-2007-01-068759
P407
P50
P577
2007-09-15T00:00:00Z