Antitumor antibiotics: bleomycin, enediynes, and mitomycin
about
Biochemical and structural insights of the early glycosylation steps in calicheamicin biosynthesisPolyketide synthase chemistry does not direct biosynthetic divergence between 9- and 10-membered enediynesBiosynthesis and function of polyacetylenes and allied natural productsLooking beneath the surface to determine what makes DNA damage deleteriousCharacterization of a novel DNA glycosylase from S. sahachiroi involved in the reduction and repair of azinomycin B induced DNA damageStructural characterization of CalO2: A putative orsellinic acid P450 oxidase in the calicheamicin biosynthetic pathwayStructural characterization of CalO1: a putative orsellinic acid methyltransferase in the calicheamicin-biosynthetic pathwayStructural characterization of the mitomycin 7-O-methyltransferaseStructure-Guided Functional Characterization of Enediyne Self-Sacrifice Resistance Proteins, CalU16 and CalU19Enzymatic methods for glyco(diversification/randomization) of drugs and small moleculesStrain Prioritization and Genome Mining for Enediyne Natural ProductsCrystal Structures of SgcE6 and SgcC, the Two-Component Monooxygenase That Catalyzes Hydroxylation of a Carrier Protein-Tethered Substrate during the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus.Detection of corneal fibrosis by imaging second harmonic-generated signals in rabbit corneas treated with mitomycin C after excimer laser surface ablation.Spirotetronate polyketides as leads in drug discovery.Effect of prophylactic and therapeutic mitomycin C on corneal apoptosis, cellular proliferation, haze, and long-term keratocyte density in rabbitsOne-year outcomes of a bilateral randomised prospective clinical trial comparing PRK with mitomycin C and LASIK.Delayed epithelial healing following photorefractive keratectomy with mitomycin C treatment.Dose-dependent effect of mitomycin C on human vocal fold fibroblastsEfficacy and safety of mitomycin C as an agent to treat corneal scarring in horses using an in vitro model.Intracellular DNA damage by lysine-acetylene conjugatesEnediyne antitumor antibiotic maduropeptin biosynthesis featuring a C-methyltransferase that acts on a CoA-tethered aromatic substrate.Mechanisms of self-resistance in the platensimycin- and platencin-producing Streptomyces platensis MA7327 and MA7339 strains.The DNA sequence specificity of bleomycin cleavage in telomeric sequences in human cells.Crystal Structure of the Zorbamycin-Binding Protein ZbmA, the Primary Self-Resistance Element in Streptomyces flavoviridis ATCC21892BlmB and TlmB provide resistance to the bleomycin family of antitumor antibiotics by N-acetylating metal-free bleomycin, tallysomycin, phleomycin, and zorbamycin.The biosynthetic genes encoding for the production of the dynemicin enediyne core in Micromonospora chersina ATCC53710Comparison of TGF-β1 in tears and corneal haze following Epi-LASIK with and without mitomycin CFunctional characterization of tlmH in Streptoalloteichus hindustanus E465-94 ATCC 31158 unveiling new insight into tallysomycin biosynthesis and affording a novel bleomycin analogBiosynthesis of enediyne antitumor antibioticsNonribosomal peptide synthetases involved in the production of medically relevant natural products.Fine-tuning alkyne cycloadditions: Insights into photochemistry responsible for the double-strand DNA cleavage via structural perturbations in diaryl alkyne conjugatesEnediyne polyketide synthases stereoselectively reduce the β-ketoacyl intermediates to β-D-hydroxyacyl intermediates in enediyne core biosynthesis.Enediynes: Exploration of microbial genomics to discover new anticancer drug leads.Genome neighborhood network reveals insights into enediyne biosynthesis and facilitates prediction and prioritization for discovery.Corneal wound healing after laser vision correction.Engineered production of cancer targeting peptide (CTP)-containing C-1027 in Streptomyces globisporus and biological evaluationA comprehensive review of glycosylated bacterial natural products.Quiescent keratocytes fail to repair MMC induced DNA damage leading to the long-term inhibition of myofibroblast differentiation and wound healingDNA damage by C1027 involves hydrogen atom abstraction and addition to nucleobases.Lovastatin prevents bleomycin-induced DNA damage to HepG2 cells.
P2860
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P2860
Antitumor antibiotics: bleomycin, enediynes, and mitomycin
description
2005 nî lūn-bûn
@nan
2005 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Antitumor antibiotics: bleomycin, enediynes, and mitomycin
@ast
Antitumor antibiotics: bleomycin, enediynes, and mitomycin
@en
Antitumor antibiotics: bleomycin, enediynes, and mitomycin
@nl
type
label
Antitumor antibiotics: bleomycin, enediynes, and mitomycin
@ast
Antitumor antibiotics: bleomycin, enediynes, and mitomycin
@en
Antitumor antibiotics: bleomycin, enediynes, and mitomycin
@nl
prefLabel
Antitumor antibiotics: bleomycin, enediynes, and mitomycin
@ast
Antitumor antibiotics: bleomycin, enediynes, and mitomycin
@en
Antitumor antibiotics: bleomycin, enediynes, and mitomycin
@nl
P2093
P3181
P356
P1433
P1476
Antitumor antibiotics: bleomycin, enediynes, and mitomycin
@en
P2093
Jianhua Ju
Jon S Thorson
Martin H Hager
Steven G Van Lanen
P304
P3181
P356
10.1021/CR030117G
P407
P577
2005-02-01T00:00:00Z