Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers - Test2 - elhamkhani - TriplyDB

Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers

Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers

http://www.wikidata.org/entity/Q28308082

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Alzheimer's disease as homeostatic responses to age-related myelin breakdown Characterizing affinity epitopes between prion protein and β-amyloid using an epitope mapping immunoassay Intranasal insulin as a treatment for Alzheimer's disease: a review of basic research and clinical evidence Rosiglitazone monotherapy in mild-to-moderate Alzheimer's disease: results from a randomized, double-blind, placebo-controlled phase III study Synthetic amyloid-beta oligomers impair long-term memory independently of cellular prion protein The toxicity of amyloid β oligomers Brain Insulin Resistance at the Crossroads of Metabolic and Cognitive Disorders in Humans The Rationale for Insulin Therapy in Alzheimer's Disease Amyloid-β Receptors: The Good, the Bad, and the Prion Protein Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer's Disease Molecular and biochemical trajectories from diabetes to Alzheimer's disease: A critical appraisal The impact of hippocampal lesions on trace-eyeblink conditioning and forebrain-cerebellar interactions Insulin: an emerging treatment for Alzheimer's disease dementia?New drug treatments show neuroprotective effects in Alzheimer's and Parkinson's diseases Alzheimer's disease and insulin resistance: translating basic science into clinical applications Elevated risk of type 2 diabetes for development of Alzheimer disease: a key role for oxidative stress in brain Insulin resistance as a key link for the increased risk of cognitive impairment in the metabolic syndrome Food for thought: the role of appetitive peptides in age-related cognitive decline Amyloid β precursor protein as a molecular target for amyloid β--induced neuronal degeneration in Alzheimer's disease Diabetes and Alzheimer disease, two overlapping pathologies with the same background: oxidative stress Aberrant insulin signaling in Alzheimer's disease: current knowledge The dendritic hypothesis for Alzheimer's disease pathophysiology.Gut-brain connection: The neuroprotective effects of the anti-diabetic drug liraglutide Role of anti-diabetic drugs as therapeutic agents in Alzheimer's disease Lipid microdomain modification sustains neuronal viability in models of Alzheimer's disease Amyloid-β triggers the release of neuronal hexokinase 1 from mitochondria Diabetes mellitus accelerates Aβ pathology in brain accompanied by enhanced GAβ generation in nonhuman primates Nanoscale Synaptic Membrane Mimetic Allows Unbiased High Throughput Screen That Targets Binding Sites for Alzheimer's-Associated Aβ Oligomers.Mechanisms underlying insulin deficiency-induced acceleration of β-amyloidosis in a mouse model of Alzheimer's disease Exercise and cognitive function: a hypothesis for the association of type II diabetes mellitus and Alzheimer's disease from an evolutionary perspective EphA4 activation of c-Abl mediates synaptic loss and LTP blockade caused by amyloid-β oligomers Diet intervention and cerebrospinal fluid biomarkers in amnestic mild cognitive impairment.Protection against the synaptic targeting and toxicity of Alzheimer's-associated Aβ oligomers by insulin mimetic chiro-inositols.Uncovering molecular biomarkers that correlate cognitive decline with the changes of hippocampus' gene expression profiles in Alzheimer's disease.Effect of apolipoprotein E genotype and diet on apolipoprotein E lipidation and amyloid peptides: randomized clinical trial Metabotropic glutamate receptor 5 knockout reduces cognitive impairment and pathogenesis in a mouse model of Alzheimer's disease.Effects of Regular and Long-Acting Insulin on Cognition and Alzheimer's Disease Biomarkers: A Pilot Clinical Trial.Alzheimer's-associated Abeta oligomers show altered structure, immunoreactivity and synaptotoxicity with low doses of oleocanthal.Insulin, cognition, and dementia Insulin Resistance as a Link between Amyloid-Beta and Tau Pathologies in Alzheimer's Disease.

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P2860

Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers

http://www.wikidata.org/entity/Q28308082

description

2009 nî lūn-bûn

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2009 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի փետրվարին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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Fernanda G De Felice

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Helena Decker

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Kirsten L Viola

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Mary P Lambert

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Pauline T Velasco

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Sergio T Ferreira

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Theresa R Bomfim

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Wei-Qin Zhao

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William L Klein

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P2860

A Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease

Pathways towards and away from Alzheimer's disease

Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

Regulation of the NMDA receptor complex and trafficking by activity-dependent phosphorylation of the NR2B subunit PDZ ligand

Regulation of NMDA receptor trafficking by amyloid-beta

Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway

A specific amyloid-beta protein assembly in the brain impairs memory

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1971-1976

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6

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106

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Marcelo N N Vieira

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23972696

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19188609

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Alzheimer's disease

Insulin receptor

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