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Crystal structure of human butyrylcholinesterase and of its complexes with substrate and productsUse of a 'caged' analogue to study the traffic of choline within acetylcholinesterase by kinetic crystallographyAging of cholinesterases phosphylated by tabun proceeds through O-dealkylationCrystallographic snapshots of nonaged and aged conjugates of soman with acetylcholinesterase, and of a ternary complex of the aged conjugate with pralidoximeStructural evidence that human acetylcholinesterase inhibited by tabun ages through O-dealkylationX-ray crystallographic snapshots of reaction intermediates in the G117H mutant of human butyrylcholinesterase, a nerve agent target engineered into a catalytic bioscavengerReaction of Cresyl Saligenin Phosphate, the Organophosphorus Agent Implicated in Aerotoxic Syndrome, with Human Cholinesterases: Mechanistic Studies Employing Kinetics, Mass Spectrometry, and X-ray Structure AnalysisStructural Study of the Complex Stereoselectivity of Human Butyrylcholinesterase for the Neurotoxic V-agentsReactibodies generated by kinetic selection couple chemical reactivity with favorable protein dynamicsA step toward the reactivation of aged cholinesterases--crystal structure of ligands binding to aged human butyrylcholinesteraseInhibition pathways of the potent organophosphate CBDP with cholinesterases revealed by X-ray crystallographic snapshots and mass spectrometryCrystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesteraseAging pathways for organophosphate-inhibited human butyrylcholinesterase, including novel pathways for isomalathion, resolved by mass spectrometry.Nerve agent analogues that produce authentic soman, sarin, tabun, and cyclohexyl methylphosphonate-modified human butyrylcholinesterase.Detection of adduct on tyrosine 411 of albumin in humans poisoned by dichlorvosMass spectral characterization of organophosphate-labeled, tyrosine-containing peptides: characteristic mass fragments and a new binding motif for organophosphatesEvolution of acetylcholinesterase and butyrylcholinesterase in the vertebrates: an atypical butyrylcholinesterase from the Medaka Oryzias latipes.Role of water in aging of human butyrylcholinesterase inhibited by echothiophate: the crystal structure suggests two alternative mechanisms of aging.Exposure to tri-o-cresyl phosphate detected in jet airplane passengers.Structure, activities and biomedical applications of human butyrylcholinesterase.Structural approach to the aging of phosphylated cholinesterases.The reactant state for substrate-activated turnover of acetylthiocholine by butyrylcholinesterase is a tetrahedral intermediate.Substrate activation in acetylcholinesterase induced by low pH or mutation in the pi-cation subsite.Engineering of a monomeric and low-glycosylated form of human butyrylcholinesterase: expression, purification, characterization and crystallization.A collaborative endeavor to design cholinesterase-based catalytic scavengers against toxic organophosphorus esters.Binding and hydrolysis of soman by human serum albumin.The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity.Application of the Ugi Multicomponent Reaction in the Synthesis of Reactivators of Nerve Agent Inhibited Acetylcholinesterase.On the Influence of the Protonation States of Active Site Residues on AChE Reactivation: A QM/MM Approach.Reactivators of acetylcholinesterase inhibited by organophosphorus nerve agents.Potent 3-hydroxy-2-pyridine aldoxime reactivators of organophosphate-inhibited cholinesterases with predicted blood-brain barrier penetration.Insights into substrate and product traffic in the Drosophila melanogaster acetylcholinesterase active site gorge by enlarging a back channel.X-ray structures of human bile-salt activated lipase conjugated to nerve agents surrogatesPurification of recombinant human butyrylcholinesterase on Hupresin®A Second Look at the Crystal Structures of Drosophila melanogaster Acetylcholinesterase in Complex with Tacrine Derivatives Provides Insights Concerning Catalytic Intermediates and the Design of Specific InsecticidesStructure-Based Optimization of Nonquaternary Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve AgentsNovel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's diseaseNew evidence for dual binding site inhibitors of acetylcholinesterase as improved drugs for treatment of Alzheimer's diseaseNovel multitarget-directed ligands targeting acetylcholinesterase and σ1 receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesteraseCharacterization of organophosphate-induced brain injuries in a convulsive mouse model of diisopropylfluorophosphate exposure
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