Abnormal purine metabolism and purine overproduction in a patient deficient in purine nucleoside phosphorylase
about
Point mutations at the purine nucleoside phosphorylase locus impair thymocyte differentiation in the mouseHuman purine nucleoside phosphorylase cDNA sequence and genomic clone characterizationDeoxyadenosine triphosphate as a mediator of deoxyguanosine toxicity in cultured T lymphoblasts2'-deoxyguanosine toxicity for B and mature T lymphoid cell lines is mediated by guanine ribonucleotide accumulationErythrocyte metabolism in purine nucleoside phosphorylase deficiency after enzyme replacement therapy by infusion of erythrocytesMitochondrial basis for immune deficiency. Evidence from purine nucleoside phosphorylase-deficient miceHeberden oration 1979: human aberrations of purine metabolism and their significance for rheumatology.Human purine metabolism: some recent advances and relationships with immunodeficiencyDeoxyadenosine triphosphate as a potentially toxic metabolite in adenosine deaminase deficiencyInfluence of bone marrow stromal microenvironment on forodesine-induced responses in CLL primary cells.Red blood cell hypoxanthine phosphoribosyltransferase activity measured using 6-mercaptopurine as a substrate: a population study in children with acute lymphoblastic leukaemiaZ-nucleotide accumulation in erythrocytes from Lesch-Nyhan patients.Lymphospecific toxicity in adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency: possible role of nucleoside kinase(s).Mechanisms of apoptosis induction by nucleoside analogs.A proof-of-principle pharmacokinetic, pharmacodynamic, and clinical study with purine nucleoside phosphorylase inhibitor immucillin-H (BCX-1777, forodesine)Purinogenic immunodeficiency diseases: selective toxicity of deoxyribonucleosides for T cells.Purine oversecretion in cultured murine lymphoma cells deficient in adenylosuccinate synthetase: genetic model for inherited hyperuricemia and goutPurinogenic immunodeficiency diseases. Differential effects of deoxyadenosine and deoxyguanosine on DNA synthesis in human T lymphoblasts.Orotic aciduria in two unrelated patients with inherited deficiencies of purine nucleoside phosphorylase.Purine nucleoside phosphorylase deficiency. Evidence for molecular heterogeneity in two families with enzyme-deficient members.Deoxyguanosine triphosphate as a possible toxic metabolite in the immunodeficiency associated with purine nucleoside phosphorylase deficiency.Isolation and characterization of purine-nucleoside phosphorylase-deficient T-lymphoma cells and secondary mutants with altered ribonucleotide reductase: genetic model for immunodeficiency disease.Selective toxicity of purine deoxynucleosides for human lymphocyte growth and function.Hypoxanthine induces cholesterol accumulation and incites atherosclerosis in apolipoprotein E-deficient mice and cells.Purine metabolism in cultured human fibroblasts derived from patients deficient in hypoxanthine phosphoribosyltransferase, purine nucleoside phosphorylase, or adenosine deaminase.Educational paper. The expanding clinical and immunological spectrum of severe combined immunodeficiency.Transition States, analogues, and drug development.Immune deficiency due to adenosine deaminase and purine nucleoside phosphorylase deficiency: a simple diagnostic test.Overview of possible relation of defects in purine metabolism to immune deficiency.Genetic studies on the role of the nucleoside transport function in nucleoside efflux, the inosine cycle, and purine biosynthesis.Effect of NADH on hypoxanthine hydroxylation by native NAD+-dependent xanthine oxidoreductase of rat liver, and the possible biological role of this effectLack of inhibition of purine nucleoside phosphorylase and adenosine deaminase in patients treated with azathioprine.A LC-MS/MS Method for Quantifying Adenosine, Guanosine and Inosine Nucleotides in Human Cells.
P2860
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P2860
Abnormal purine metabolism and purine overproduction in a patient deficient in purine nucleoside phosphorylase
description
1976 nî lūn-bûn
@nan
1976 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1976 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1976年の論文
@ja
1976年論文
@yue
1976年論文
@zh-hant
1976年論文
@zh-hk
1976年論文
@zh-mo
1976年論文
@zh-tw
1976年论文
@wuu
name
Abnormal purine metabolism and ...... urine nucleoside phosphorylase
@ast
Abnormal purine metabolism and ...... urine nucleoside phosphorylase
@en
Abnormal purine metabolism and ...... urine nucleoside phosphorylase
@nl
type
label
Abnormal purine metabolism and ...... urine nucleoside phosphorylase
@ast
Abnormal purine metabolism and ...... urine nucleoside phosphorylase
@en
Abnormal purine metabolism and ...... urine nucleoside phosphorylase
@nl
prefLabel
Abnormal purine metabolism and ...... urine nucleoside phosphorylase
@ast
Abnormal purine metabolism and ...... urine nucleoside phosphorylase
@en
Abnormal purine metabolism and ...... urine nucleoside phosphorylase
@nl
P2093
P3181
P1476
Abnormal purine metabolism and ...... urine nucleoside phosphorylase
@en
P2093
P304
P3181
P356
10.1056/NEJM197612232952603
P407
P577
1976-12-23T00:00:00Z