Identification of overlapping but distinct cAMP and cGMP interaction sites with cyclic nucleotide phosphodiesterase 3A by site-directed mutagenesis and molecular modeling based on crystalline PDE4B
about
PfPDE1, a novel cGMP-specific phosphodiesterase from the human malaria parasite Plasmodium falciparumInsight into the phosphodiesterase mechanism from combined QM/MM free energy simulations.A new nonhydrolyzable reactive cGMP analogue, (Rp)-guanosine-3',5'-cyclic-S-(4-bromo-2,3-dioxobutyl)monophosphorothioate, which targets the cGMP binding site of human platelet PDE3A.Design, synthesis, and structure-activity relationship, molecular modeling, and NMR studies of a series of phenyl alkyl ketones as highly potent and selective phosphodiesterase-4 inhibitors.Design, synthesis and pharmacological evaluation of 6-hydroxy-4-methylquinolin-2(1H)-one derivatives as inotropic agents.
P2860
Identification of overlapping but distinct cAMP and cGMP interaction sites with cyclic nucleotide phosphodiesterase 3A by site-directed mutagenesis and molecular modeling based on crystalline PDE4B
description
2001 nî lūn-bûn
@nan
2001 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Identification of overlapping ...... ing based on crystalline PDE4B
@ast
Identification of overlapping ...... ing based on crystalline PDE4B
@en
Identification of overlapping ...... ing based on crystalline PDE4B
@nl
type
label
Identification of overlapping ...... ing based on crystalline PDE4B
@ast
Identification of overlapping ...... ing based on crystalline PDE4B
@en
Identification of overlapping ...... ing based on crystalline PDE4B
@nl
prefLabel
Identification of overlapping ...... ing based on crystalline PDE4B
@ast
Identification of overlapping ...... ing based on crystalline PDE4B
@en
Identification of overlapping ...... ing based on crystalline PDE4B
@nl
P2093
P2860
P356
P1433
P1476
Identification of overlapping ...... ing based on crystalline PDE4B
@en
P2093
P2860
P304
P356
10.1110/PS.6601
P407
P577
2001-08-01T00:00:00Z