Rapamycin and less immunosuppressive analogs are toxic to Candida albicans and Cryptococcus neoformans via FKBP12-dependent inhibition of TOR
about
Elucidating TOR signaling and rapamycin action: lessons from Saccharomyces cerevisiae.Large FK506-Binding Proteins Shape the Pharmacology of RapamycinMds3 regulates morphogenesis in Candida albicans through the TOR pathwayThe protein kinase Tor1 regulates adhesin gene expression in Candida albicansRole of Ess1 in growth, morphogenetic switching, and RNA polymerase II transcription in Candida albicansCharacterization of the FKBP12-Encoding Genes in Aspergillus fumigatusAntifungal activities of tacrolimus and azole agents against the eleven currently accepted Malassezia speciesAntifungal application of nonantifungal drugsCalcineurin inhibitor agents interact synergistically with antifungal agents in vitro against Cryptococcus neoformans isolates: correlation with outcome in solid organ transplant recipients with cryptococcosis.Identification and comparative analysis of sixteen fungal peptidyl-prolyl cis/trans isomerase repertoires.Importance of microbial natural products and the need to revitalize their discovery.Homoserine toxicity in Saccharomyces cerevisiae and Candida albicans homoserine kinase (thr1Delta) mutantsThe TOR signal transduction cascade controls cellular differentiation in response to nutrients.Hyphal development in Candida albicans requires two temporally linked changes in promoter chromatin for initiation and maintenance.Calcineurin is essential for survival during membrane stress in Candida albicans.Modulation of morphogenesis in Candida albicans by various small molecules.Monitoring molecular-specific pharmacodynamics of rapamycin in vivo with inducible Gal4->Fluc transgenic reporter mice.Regulation of Hxt3 and Hxt7 turnover converges on the Vid30 complex and requires inactivation of the Ras/cAMP/PKA pathway in Saccharomyces cerevisiaeCalcineurin inhibitors and rapamycin: cancer protection or promotion?Ergosterol biosynthesis inhibitors become fungicidal when combined with calcineurin inhibitors against Candida albicans, Candida glabrata, and Candida krusei.Direct effects of non-antifungal agents used in cancer chemotherapy and organ transplantation on the development and virulence of Candida and Aspergillus speciesRhb1 regulates the expression of secreted aspartic protease 2 through the TOR signaling pathway in Candida albicans.Dual action antifungal small molecule modulates multidrug efflux and TOR signalingCombined image guided monitoring the pharmacokinetics of rapamycin loaded human serum albumin nanoparticles with a split luciferase reporterReduced TOR signaling sustains hyphal development in Candida albicans by lowering Hog1 basal activity.The structure of the Candida albicans Ess1 prolyl isomerase reveals a well-ordered linker that restricts domain mobilityThe role and value of sirolimus administration in kidney and liver transplantation.Structures of Pathogenic Fungal FKBP12s Reveal Possible Self-Catalysis Function.Diverse Hap43-independent functions of the Candida albicans CCAAT-binding complex.Shuttle vectors for facile gap repair cloning and integration into a neutral locus in Candida albicans.Calcineurin regulation in fungi and beyondCombination therapeutic approaches for the management of invasive aspergillosis in organ transplant recipients.Old Cryptococcus neoformans cells contribute to virulence in chronic cryptococcosis.Cryptococcus neoformans constitutes an ideal model organism to unravel the contribution of cellular aging to the virulence of chronic infections.GLN3 encodes a global regulator of nitrogen metabolism and virulence of C. albicans.Signaling cascades as drug targets in model and pathogenic fungi.In vitro interactions between antifungals and immunosuppressive drugs against zygomycetes.Inhibitors of cellular signalling are cytotoxic or block the budded-to-hyphal transition in the pathogenic yeast Candida albicans.Our paths might cross: the role of the fungal cell wall integrity pathway in stress response and cross talk with other stress response pathways.In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus isolates from transplant and nontransplant patients.
P2860
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P2860
Rapamycin and less immunosuppressive analogs are toxic to Candida albicans and Cryptococcus neoformans via FKBP12-dependent inhibition of TOR
description
2001 nî lūn-bûn
@nan
2001 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Rapamycin and less immunosuppr ...... 12-dependent inhibition of TOR
@ast
Rapamycin and less immunosuppr ...... 12-dependent inhibition of TOR
@en
Rapamycin and less immunosuppr ...... 12-dependent inhibition of TOR
@nl
type
label
Rapamycin and less immunosuppr ...... 12-dependent inhibition of TOR
@ast
Rapamycin and less immunosuppr ...... 12-dependent inhibition of TOR
@en
Rapamycin and less immunosuppr ...... 12-dependent inhibition of TOR
@nl
prefLabel
Rapamycin and less immunosuppr ...... 12-dependent inhibition of TOR
@ast
Rapamycin and less immunosuppr ...... 12-dependent inhibition of TOR
@en
Rapamycin and less immunosuppr ...... 12-dependent inhibition of TOR
@nl
P2093
P2860
P3181
P1476
Rapamycin and less immunosuppr ...... 12-dependent inhibition of TOR
@en
P2093
A L Goldstein
J Blankenship
J H McCusker
J R Perfect
M Del Poeta
M E Cardenas
Y L Bennani
P2860
P304
P3181
P356
10.1128/AAC.45.11.3162-3170.2001
P407
P577
2001-11-01T00:00:00Z