5-Alkyl-2-(alkylthio)-6-(2,6-dihalophenylmethyl)-3, 4-dihydropyrimidin-4(3H)-ones: novel potent and selective dihydro-alkoxy-benzyl-oxopyrimidine derivatives
about
SJ-3366, a unique and highly potent nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1 (HIV-1) that also inhibits HIV-2DB-02, a C-6-cyclohexylmethyl substituted pyrimidinone HIV-1 reverse transcriptase inhibitor with nanomolar activity, displays an improved sensitivity against K103N or Y181C than S-DABOsChiral resolution and molecular modeling investigation of rac-2-cyclopentylthio-6-[1-(2,6-difluorophenyl)ethyl]-3,4-dihydro-5-methylpyrimidin-4(3H)-one (MC-1047), a potent anti-HIV-1 reverse transcriptase agent of the DABO class.Non-nucleoside reverse transcriptase inhibitors: the NNRTI boom.Synthesis and biological evaluation of 2-thioxopyrimidin-4(1H)-one derivatives as potential non-nucleoside HIV-1 reverse transcriptase inhibitors.Design, synthesis, and biological evaluation of 1-[(2-benzyloxyl/alkoxyl)methyl]-5-halo-6-aryluracils as potent HIV-1 non-nucleoside reverse transcriptase inhibitors with an improved drug resistance profile.Significance and biological importance of pyrimidine in the microbial world.Discovery of dihydro-alkyloxy-benzyl-oxopyrimidines as promising anti-influenza virus agents.The structure-activity relationships of 2,4(1H,3H)-pyrimidinedione derivatives as potent HIV type 1 and type 2 inhibitors.Comparative evaluation of the inhibitory activities of a series of pyrimidinedione congeners that inhibit human immunodeficiency virus types 1 and 2.3D-QSAR analysis of a series of S-DABO derivatives as anti-HIV agents by CoMFA and CoMSIA.Structure-activity relationship studies on new DABOS: effect of substitutions at pyrimidine C-5 and C-6 positions on anti-HIV-1 activity.Structure-activity relationship studies on potential non-nucleoside DABO-like inhibitors of HIV-1 reverse transcriptase.Synthesis and antiviral activity of 1,3-disubstituted uracils against HIV-1 and HCMV.Nucleoside analogues exerting antiviral activity through a non-nucleoside mechanism.Synthesis, NMR conformational analysis and pharmacological evaluation of 7,7a,13,14-tetrahydro-6H-cyclobuta[b]pyrimido[1,2-a:3,4-a']diindole analogues as melatonin receptor ligands.Topochemical models for prediction of anti-HIV activity of 4-benzyl pyridinone derivatives.Eurotiumins A⁻E, Five New Alkaloids from the Marine-Derived Fungus Eurotium sp. SCSIO F452.
P2860
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P2860
5-Alkyl-2-(alkylthio)-6-(2,6-dihalophenylmethyl)-3, 4-dihydropyrimidin-4(3H)-ones: novel potent and selective dihydro-alkoxy-benzyl-oxopyrimidine derivatives
description
1999 nî lūn-bûn
@nan
1999 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
5-Alkyl-2-(alkylthio)-6-(2,6-d ...... nzyl-oxopyrimidine derivatives
@ast
5-Alkyl-2-(alkylthio)-6-(2,6-d ...... nzyl-oxopyrimidine derivatives
@en
5-Alkyl-2-(alkylthio)-6-(2,6-d ...... nzyl-oxopyrimidine derivatives
@nl
type
label
5-Alkyl-2-(alkylthio)-6-(2,6-d ...... nzyl-oxopyrimidine derivatives
@ast
5-Alkyl-2-(alkylthio)-6-(2,6-d ...... nzyl-oxopyrimidine derivatives
@en
5-Alkyl-2-(alkylthio)-6-(2,6-d ...... nzyl-oxopyrimidine derivatives
@nl
prefLabel
5-Alkyl-2-(alkylthio)-6-(2,6-d ...... nzyl-oxopyrimidine derivatives
@ast
5-Alkyl-2-(alkylthio)-6-(2,6-d ...... nzyl-oxopyrimidine derivatives
@en
5-Alkyl-2-(alkylthio)-6-(2,6-d ...... nzyl-oxopyrimidine derivatives
@nl
P2093
P50
P356
P1476
5-Alkyl-2-(alkylthio)-6-(2,6-d ...... nzyl-oxopyrimidine derivatives
@en
P2093
P304
P356
10.1021/JM980260F
P407
P577
1999-02-25T00:00:00Z