Identification and characterization of a potent, selective, and orally active antagonist of the CC chemokine receptor-1
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The pan-chemokine inhibitor NR58-3.14.3 abolishes tumour necrosis factor-alpha accumulation and leucocyte recruitment induced by lipopolysaccharide in vivoInvolvement of beta-chemokines in the development of inflammatory demyelinationCloning and functional characterization of the rabbit C-C chemokine receptor 2The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptorsAnti-CCL2 treatment inhibits Theiler's murine encephalomyelitis virus-induced demyelinating diseaseEmerging concepts and approaches for chemokine-receptor drug discovery.Structure modeling of the chemokine receptor CCR5: implications for ligand binding and selectivity.Chemokines, innate and adaptive immunity, and respiratory disease.New therapeutics that modulate chemokine networks.Therapeutic targeting of CCR1 attenuates established chronic fungal asthma in mice.G protein-coupled receptors--recent advancesSB-656933, a novel CXCR2 selective antagonist, inhibits ex vivo neutrophil activation and ozone-induced airway inflammation in humansBone anabolic agents for the treatment of multiple myeloma.Temporal expression and cellular origin of CC chemokine receptors CCR1, CCR2 and CCR5 in the central nervous system: insight into mechanisms of MOG-induced EAE.Multiple myeloma/hypercalcemia.CCL5, CCR1 and CCR5 in murine glioblastoma: immune cell infiltration and survival rates are not dependent on individual expression of either CCR1 or CCR5Leukocytes induce epithelial to mesenchymal transition after unilateral ureteral obstruction in neonatal miceCCR1 antagonists in clinical development.Chemokines and chemokine receptors in multiple sclerosis. Potential targets for new therapies.Chemokines and chemokine receptors in neurological disease: raise, retain, or reduce?G protein-coupled receptors as therapeutic targets for multiple sclerosis.Assessment of QT(c)-prolonging potential of BX471 in healthy volunteers. A 'thorough QT study' following ICH E14 using various QT(c) correction methodsInternational Union of Basic and Clinical Pharmacology. [corrected]. LXXXIX. Update on the extended family of chemokine receptors and introducing a new nomenclature for atypical chemokine receptors.Chemokine receptor antagonists: Part 1.Anti-chemokine small molecule drugs: a promising future?CCR1 as a target for multiple myeloma.Therapeutic potential of CCR1 antagonists for multiple myeloma.A chemokine receptor CCR-1 antagonist reduces renal fibrosis after unilateral ureter ligation.Ticks produce highly selective chemokine binding proteins with antiinflammatory activity.Cloning, expression, and functional characterization of cynomolgus monkey (Macaca fascicularis) CC chemokine receptor 1.Site-directed mutagenesis of CC chemokine receptor 1 reveals the mechanism of action of UCB 35625, a small molecule chemokine receptor antagonist.A non-peptide functional antagonist of the CCR1 chemokine receptor is effective in rat heart transplant rejection.Pharmacological blockade of CCR1 ameliorates murine arthritis and alters cytokine networks in vivo.The role of the human Duffy antigen receptor for chemokines in malaria susceptibility: current opinions and future treatment prospects.Reversed binding of a small molecule ligand in homologous chemokine receptors - differential role of extracellular loop 2.CP-481,715, a potent and selective CCR1 antagonist with potential therapeutic implications for inflammatory diseases.Predictions of CCR1 chemokine receptor structure and BX 471 antagonist binding followed by experimental validation.Chemokines and chemokine receptors in the pathogenesis of systemic sclerosis.Efficacy, safety and tolerability of the CCR1 antagonist BAY 86-5047 for the treatment of endometriosis-associated pelvic pain: a randomized controlled trial.Overview of high-throughput screening.
P2860
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P2860
Identification and characterization of a potent, selective, and orally active antagonist of the CC chemokine receptor-1
description
2000 nî lūn-bûn
@nan
2000 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Identification and characteriz ...... of the CC chemokine receptor-1
@ast
Identification and characteriz ...... of the CC chemokine receptor-1
@en
Identification and characteriz ...... of the CC chemokine receptor-1
@nl
type
label
Identification and characteriz ...... of the CC chemokine receptor-1
@ast
Identification and characteriz ...... of the CC chemokine receptor-1
@en
Identification and characteriz ...... of the CC chemokine receptor-1
@nl
prefLabel
Identification and characteriz ...... of the CC chemokine receptor-1
@ast
Identification and characteriz ...... of the CC chemokine receptor-1
@en
Identification and characteriz ...... of the CC chemokine receptor-1
@nl
P2093
P2860
P356
P1476
Identification and characteriz ...... of the CC chemokine receptor-1
@en
P2093
B Subramanyam
P2860
P304
P356
10.1074/JBC.M001222200
P407
P577
2000-06-23T00:00:00Z