SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic glutamate receptor type 5
about
Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEPPotential anxiolytic- and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonistSelective mGluR5 antagonists MPEP and SIB-1893 decrease NMDA or glutamate-mediated neuronal toxicity through actions that reflect NMDA receptor antagonismNeurobiological Insights from mGlu Receptor Allosteric Modulation.Allosteric modulation of metabotropic glutamate receptors.Alzheimer's disease and Down syndrome rodent models exhibit audiogenic seizures.The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptorsA basis for reduced chemical library inhibition of firefly luciferase obtained from directed evolutionA novel, competitive mGlu(5) receptor antagonist (LY344545) blocks DHPG-induced potentiation of NMDA responses but not the induction of LTP in rat hippocampal slices.Fenobam sulfate inhibits cocaine-taking and cocaine-seeking behavior in rats: implications for addiction treatment in humans.Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders.Neuroprotective activity of the mGluR5 antagonists MPEP and MTEP against acute excitotoxicity differs and does not reflect actions at mGluR5 receptors.Interactions between adenosine and metabotropic glutamate receptors in the rat hippocampal slice.Therapeutic potential of mGluR5 targeting in Alzheimer's diseaseInvestigating metabotropic glutamate receptor 5 allosteric modulator cooperativity, affinity, and agonism: enriching structure-function studies and structure-activity relationships.Probing the metabotropic glutamate receptor 5 (mGlu₅) positive allosteric modulator (PAM) binding pocket: discovery of point mutations that engender a "molecular switch" in PAM pharmacology.Metabotropic glutamate receptor ligands as potential therapeutics for addictionAllosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders.MPEP reduces seizure severity in Fmr-1 KO mice over expressing human AbetaMetabotropic glutamate receptors: physiology, pharmacology, and disease.Identification of specific ligand-receptor interactions that govern binding and cooperativity of diverse modulators to a common metabotropic glutamate receptor 5 allosteric site.Early-Onset Network Hyperexcitability in Presymptomatic Alzheimer's Disease Transgenic Mice Is Suppressed by Passive Immunization with Anti-Human APP/Aβ Antibody and by mGluR5 Blockade.Metabotropic glutamate receptor subtype 5 antagonism in learning and memory.Allosteric modulation of metabotropic glutamate receptors: structural insights and therapeutic potential.Recent progress on the identification of metabotropic glutamate 4 receptor ligands and their potential utility as CNS therapeutics.Progress toward advanced understanding of metabotropic glutamate receptors: structure, signaling and therapeutic indicationsThe nuclear factor κB inhibitor (E)-2-fluoro-4'-methoxystilbene inhibits firefly luciferase.Development of [(123)I]IPEB and [(123)I]IMPEB as SPECT Radioligands for Metabotropic Glutamate Receptor Subtype 5.Metabotropic glutamate receptors: potential drug targets for psychiatric disorders.Metabotropic glutamate receptors for Parkinson's disease therapy.Illuminating Phenylazopyridines To Photoswitch Metabotropic Glutamate Receptors: From the Flask to the Animals.
P2860
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P2860
SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic glutamate receptor type 5
description
1999 nî lūn-bûn
@nan
1999 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
name
SIB-1757 and SIB-1893: selecti ...... opic glutamate receptor type 5
@ast
SIB-1757 and SIB-1893: selecti ...... opic glutamate receptor type 5
@en
SIB-1757 and SIB-1893: selecti ...... opic glutamate receptor type 5
@nl
type
label
SIB-1757 and SIB-1893: selecti ...... opic glutamate receptor type 5
@ast
SIB-1757 and SIB-1893: selecti ...... opic glutamate receptor type 5
@en
SIB-1757 and SIB-1893: selecti ...... opic glutamate receptor type 5
@nl
prefLabel
SIB-1757 and SIB-1893: selecti ...... opic glutamate receptor type 5
@ast
SIB-1757 and SIB-1893: selecti ...... opic glutamate receptor type 5
@en
SIB-1757 and SIB-1893: selecti ...... opic glutamate receptor type 5
@nl
P2093
P1476
SIB-1757 and SIB-1893: selecti ...... opic glutamate receptor type 5
@en
P2093
E C Johnson
E M Santori
F Gasparini
G Veliçelebi
H Allgeier
L Bleicher
M A Varney
P304
P407
P577
1999-07-01T00:00:00Z