A genetically hard-wired metabolic transcriptome in Plasmodium falciparum fails to mount protective responses to lethal antifolates
about
Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparumCharacterization and structural studies of the Plasmodium falciparum ubiquitin and Nedd8 hydrolase UCHL3A genomic and evolutionary approach reveals non-genetic drug resistance in malariaPlasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase is a potential drug targetRole of calcium signaling in the transcriptional regulation of the apicoplast genome of Plasmodium falciparumMuddled mechanisms: recent progress towards antimalarial target identificationHistone deacetylases play a major role in the transcriptional regulation of the Plasmodium falciparum life cycleAntimalarial exposure delays Plasmodium falciparum intra-erythrocytic cycle and drives drug transporter genes expressionGenome wide adaptations of Plasmodium falciparum in response to lumefantrine selective drug pressureAsexual populations of the human malaria parasite, Plasmodium falciparum, use a two-step genomic strategy to acquire accurate, beneficial DNA amplificationsInducible knockdown of Plasmodium gene expression using the glmS ribozymeTopoisomerase II from Human Malaria Parasites: EXPRESSION, PURIFICATION, AND SELECTIVE INHIBITIONPlasmodium falciparum spermidine synthase inhibition results in unique perturbation-specific effects observed on transcript, protein and metabolite levels.Nucleosome landscape and control of transcription in the human malaria parasiteThree-dimensional modeling of the P. falciparum genome during the erythrocytic cycle reveals a strong connection between genome architecture and gene expressionFrequent GU wobble pairings reduce translation efficiency in Plasmodium falciparumA novel multifunctional oligonucleotide microarray for Toxoplasma gondii.Comparative gene expression profiling of P. falciparum malaria parasites exposed to three different histone deacetylase inhibitorsA view on the role of epigenetics in the biology of malaria parasites.Module-based subnetwork alignments reveal novel transcriptional regulators in malaria parasite Plasmodium falciparum.A systems biological view of intracellular pathogensModel system to define pharmacokinetic requirements for antimalarial drug efficacy.Chemical genomics for studying parasite gene function and interaction.Genome-wide regulatory dynamics of translation in the Plasmodium falciparum asexual blood stages.Global gene expression profiling of Plasmodium falciparum in response to the anti-malarial drug pyronaridineGenomics and integrated systems biology in Plasmodium falciparum: a path to malaria control and eradication.An integrative analysis of small molecule transcriptional responses in the human malaria parasite Plasmodium falciparumGenome-wide transcriptome profiling reveals functional networks involving the Plasmodium falciparum drug resistance transporters PfCRT and PfMDR1Cytochrome b mutation Y268S conferring atovaquone resistance phenotype in malaria parasite results in reduced parasite bc1 catalytic turnover and protein expressionTranscriptional variation in the malaria parasite Plasmodium falciparumNew Agilent platform DNA microarrays for transcriptome analysis of Plasmodium falciparum and Plasmodium berghei for the malaria research communityEpigenetic dysregulation of virulence gene expression in severe Plasmodium falciparum malaria.Plasmodium parasites mount an arrest response to dihydroartemisinin, as revealed by whole transcriptome shotgun sequencing (RNA-seq) and microarray study.Nucleosome occupancy at transcription start sites in the human malaria parasite: a hard-wired evolution of virulence?Protein S-glutathionylation in malaria parasites.Comparative Genomics and Systems Biology of Malaria Parasites Plasmodium.Expression of functional Plasmodium falciparum enzymes using a wheat germ cell-free systemMalaria evolution in South Asia: knowledge for control and elimination.Epigenetics in Plasmodium: what do we really know?Target identification and validation of novel antimalarials.
P2860
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P2860
A genetically hard-wired metabolic transcriptome in Plasmodium falciparum fails to mount protective responses to lethal antifolates
description
2008 nî lūn-bûn
@nan
2008 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
A genetically hard-wired metab ...... esponses to lethal antifolates
@ast
A genetically hard-wired metab ...... esponses to lethal antifolates
@en
A genetically hard-wired metab ...... esponses to lethal antifolates
@nl
type
label
A genetically hard-wired metab ...... esponses to lethal antifolates
@ast
A genetically hard-wired metab ...... esponses to lethal antifolates
@en
A genetically hard-wired metab ...... esponses to lethal antifolates
@nl
prefLabel
A genetically hard-wired metab ...... esponses to lethal antifolates
@ast
A genetically hard-wired metab ...... esponses to lethal antifolates
@en
A genetically hard-wired metab ...... esponses to lethal antifolates
@nl
P2093
P2860
P3181
P1433
P1476
A genetically hard-wired metab ...... esponses to lethal antifolates
@en
P2093
John White
Joseph W Fowble
Karthikeyan Ganesan
Napawan Ponmee
Pradipsinh K Rathod
Prapon Wilairat
P2860
P304
P3181
P356
10.1371/JOURNAL.PPAT.1000214
P407
P577
2008-11-21T00:00:00Z