4'-Phosphopantetheinyl transferase PptT, a new drug target required for Mycobacterium tuberculosis growth and persistence in vivo - Test2 - elhamkhani - TriplyDB

4'-Phosphopantetheinyl transferase PptT, a new drug target required for Mycobacterium tuberculosis growth and persistence in vivo

4'-Phosphopantetheinyl transferase PptT, a new drug target required for Mycobacterium tuberculosis growth and persistence in vivo

http://www.wikidata.org/entity/Q28484764

about

The application of tetracyclineregulated gene expression systems in the validation of novel drug targets in Mycobacterium tuberculosis Structure, Biochemistry, and Inhibition of Essential 4′-Phosphopantetheinyl Transferases from Two Species of Mycobacteria Trehalose-6-Phosphate-Mediated Toxicity Determines Essentiality of OtsB2 in Mycobacterium tuberculosis In Vitro and in Mice The phosphopantetheinyl transferases: catalysis of a post-translational modification crucial for life A Nonredundant Phosphopantetheinyl Transferase, PptA, Is a Novel Antifungal Target That Directs Secondary Metabolite, Siderophore, and Lysine Biosynthesis in Aspergillus fumigatus and Is Critical for Pathogenicity.Regulated Expression Systems for Mycobacteria and Their Applications 4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-methoxypyridin-2-yl)piperazine-1-carbothioamide (ML267), a potent inhibitor of bacterial phosphopantetheinyl transferase that attenuates secondary metabolism and thwarts bacterial growth.Paenibacillus polymyxa A26 Sfp-type PPTase inactivation limits bacterial antagonism against Fusarium graminearum but not of F. culmorum in kernel assay.Breaking a pathogen's iron will: Inhibiting siderophore production as an antimicrobial strategy Genetic Approaches to Facilitate Antibacterial Drug Development.A genetic strategy to identify targets for the development of drugs that prevent bacterial persistence.Validation of CoaBC as a Bactericidal Target in the Coenzyme A Pathway of Mycobacterium tuberculosis.Depleting Mycobacterium tuberculosis of the transcription termination factor Rho causes pervasive transcription and rapid death Biosynthesis of mycobacterial lipids by polyketide synthases and beyond.Newer patents in antimycobacterial therapy.Survival proteomes: the emerging proteotype of antimicrobial resistance.Fluorescent techniques for discovery and characterization of phosphopantetheinyl transferase inhibitors.Sfp-type PPTase inactivation promotes bacterial biofilm formation and ability to enhance wheat drought tolerance.Global adaptation to a lipid environment triggers the dormancy-related phenotype of Mycobacterium tuberculosis.Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform.Insights from the docking and molecular dynamics simulation of the Phosphopantetheinyl transferase (PptT) structural model from Mycobacterium tuberculosis.Mass spectral determination of phosphopantetheinylation specificity for carrier proteins in Mycobacterium tuberculosis A Chemoproteomics Approach to Investigate Phosphopantetheine Transferase Activity at the Cellular Level.The Emergence of the First Cells

P2860

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P2860

4'-Phosphopantetheinyl transferase PptT, a new drug target required for Mycobacterium tuberculosis growth and persistence in vivo

http://www.wikidata.org/entity/Q28484764

description

2012 nî lūn-bûn

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2012 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

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2012 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

4'-Phosphopantetheinyl transfe ...... growth and persistence in vivo

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4'-Phosphopantetheinyl transfe ...... growth and persistence in vivo

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4'-Phosphopantetheinyl transfe ...... growth and persistence in vivo

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4'-Phosphopantetheinyl transfe ...... growth and persistence in vivo

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4'-Phosphopantetheinyl transfe ...... growth and persistence in vivo

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JOURNAL.PPAT.1003097

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4'-Phosphopantetheinyl transfe ...... growth and persistence in vivo

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Aurélie Ray

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Christian Chalut

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Christophe Guilhot

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Cécile Leblanc

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Guillaume Tabouret

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Lionel Mourey

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Sophie Burbaud

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Stéphanie Cabantous

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Thomas Prudhomme

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P2860

A minimal peptide substrate in biotin holoenzyme synthetase-catalyzed biotinylation

Gatifloxacin and ethionamide as the foundation for therapy of tuberculosis

Controlling gene expression in mycobacteria with anhydrotetracycline and Tet repressor

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

Post-translational modification of polyketide and nonribosomal peptide synthases

Mycolic acids: structure, biosynthesis and physiological functions

The salicylate-derived mycobactin siderophores of Mycobacterium tuberculosis are essential for growth in macrophages

Mycobacterium leprae phenolglycolipid-1 expressed by engineered M. bovis BCG modulates early interaction with human phagocytes

Evaluating the sensitivity of Mycobacterium tuberculosis to biotin deprivation using regulated gene expression

Phthiocerol dimycocerosates of M. tuberculosis participate in macrophage invasion by inducing changes in the organization of plasma membrane lipids

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e1003097

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234106092

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23308068

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Mycobacterium tuberculosis

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