Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing
about
Molecular pathological epidemiology of epigenetics: emerging integrative science to analyze environment, host, and diseaseCpG island methylation in colorectal cancer: past, present and futureInduced pluripotent stem cell technology for dissecting the cancer epigenomeDedifferentiation and reprogramming: origins of cancer stem cellsActive DNA demethylation of the vertebrate genomes by DNA methyltransferases: deaminase, dehydroxymethylase or demethylase?Epigenetic regulation of the intestinal epitheliumModulation of Dnmt3b function in vitro by interactions with Dnmt3L, Dnmt3a and Dnmt3b splice variantsAntiproliferative effects of DNA methyltransferase 3B depletion are not associated with DNA demethylationAberrant DNA methylation occurs in colon neoplasms arising in the azoxymethane colon cancer modelECRG4 is a candidate tumor suppressor gene frequently hypermethylated in colorectal carcinoma and glioma.C57BL/6J mice as a polygenic developmental model of diet-induced obesity.A role for the Werner syndrome protein in epigenetic inactivation of the pluripotency factor Oct4.DNA methyltransferases: a novel target for prevention and therapy.DNMT3a epigenetic program regulates the HIF-2α oxygen-sensing pathway and the cellular response to hypoxia.Widespread and tissue specific age-related DNA methylation changes in mice.DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus.HOXB13, a target of DNMT3B, is methylated at an upstream CpG island, and functions as a tumor suppressor in primary colorectal tumors.Methylation of the SPARC gene promoter and its clinical implication in pancreatic cancer.DNMT3B expression might contribute to CpG island methylator phenotype in colorectal cancerA DNA methyltransferase inhibitor and all-trans retinoic acid reduce oral cavity carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide.A DNMT3B alternatively spliced exon and encoded peptide are novel biomarkers of human pluripotent stem cellsB vitamins, methionine and alcohol intake and risk of colon cancer in relation to BRAF mutation and CpG island methylator phenotype (CIMP).Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens.The influence of cis-regulatory elements on DNA methylation fidelity.ATRA inhibits the proliferation of DU145 prostate cancer cells through reducing the methylation level of HOXB13 gene.Novel application of structural equation modeling to correlation structure analysis of CpG island methylation in colorectal cancerDietary methyl donors, methyl metabolizing enzymes, and epigenetic regulators: diet-gene interactions and promoter CpG island hypermethylation in colorectal cancer.Gene body methylation can alter gene expression and is a therapeutic target in cancer.Identification of preferential target sites for human DNA methyltransferases.Dnmt3a protects active chromosome domains against cancer-associated hypomethylation.Maternal transmission of a humanised Igf2r allele results in an Igf2 dependent hypomorphic and non-viable growth phenotypeGenomic insights into cancer-associated aberrant CpG island hypermethylationEpigenetic regulation in neural crest development.Downregulation of microRNA-29c is associated with hypermethylation of tumor-related genes and disease outcome in cutaneous melanomaDNA methyltransferase 3B regulates duration of neural crest production via repression of Sox10Genes methylated by DNA methyltransferase 3b are similar in mouse intestine and human colon cancer.Hypermethylation of multiple tumor-related genes associated with DNMT3b up-regulation served as a biomarker for early diagnosis of esophageal squamous cell carcinomaThe human melanoma side population displays molecular and functional characteristics of enriched chemoresistance and tumorigenesis.Reduction of pancreatic acinar cell tumor multiplicity in Dnmt1 hypomorphic mice.Inhibition of intestinal tumor formation by deletion of the DNA methyltransferase 3a.
P2860
Q24289344-402C2582-7C5D-4370-9D05-5E37A17CED24Q24597977-A1EAA625-2542-474C-BE76-F98F248ABC34Q26801711-2A06B54A-948F-4086-AF68-DF169A8EFFCAQ26826876-517D2680-E13C-48D2-8D93-5492C66C4073Q27001209-50F38576-9150-4B97-99FA-C90EFB54B8FFQ28084849-7EA822F2-0C1F-48E8-B160-8311BD5044C6Q28593679-97FBC63E-3E55-47D2-8864-D86B481138F0Q28730186-A609EEB1-6453-4E0E-9BDD-5839B8DD6A3CQ30494652-6354E335-1F31-4A16-AB5A-DEB3CC0F33A4Q33519164-9A82C1EB-694F-4BD4-BE05-043A8FA0EB49Q33567427-4579AC9A-EDA1-4D3F-97E9-14B08F088F64Q33579422-A646D493-5F0D-4E50-AE40-AA67E97124FDQ33579896-4E246CD0-5723-4CA4-97F8-720F2E7DF604Q33694616-C1AF1D5E-F592-426F-8009-82B9F47177E2Q33736551-F44B21A2-93FA-4E81-B5C5-9D30E0B0BFF6Q33742017-61195487-D420-4615-A832-E73242830188Q33818402-BA8BBC04-31A0-49B7-8F10-B8F33A22682FQ33820209-08F19687-CA44-453E-BE21-E76E693574E8Q33837632-1481590C-5761-4451-B205-82D3BEB80DF2Q33880963-A347C589-E5FD-4890-AB8E-5CA7D916DC91Q33941252-216BF8D2-2FE4-40A1-8BED-B8C20FC993A5Q33954696-FE4AB683-4EDE-4E3A-B5A6-8431B7DA0B28Q34086476-65D70FA8-2519-4EF7-9314-E518403C7977Q34193554-029EE1FA-DD14-4B4E-A882-F2F3DC288EBEQ34342517-4375C955-8B1A-49F2-A912-019C01974ACEQ34358286-37F8EE9C-A5D8-4915-A04B-DBC703D9BD0EQ34407309-5ABA221B-0C3E-48DC-A60D-490B85C3793DQ34471361-F6455685-B98B-45BC-B7F2-FC52FA6CEFC6Q34474148-F1E2FABB-289B-4263-B526-0BDE7A0FF86DQ34531301-05A49710-D2C1-4CE9-B475-A1E54C6B78B5Q34611930-D55124AC-7F06-4E3F-9C8B-00F06ED0A2B5Q34647477-54D71A45-8F4D-4CAA-97FC-DB01C72BA12FQ34663839-645DE9EE-CB35-49FF-9C85-65526D2BDA4FQ34713622-62943D44-B294-4800-8D89-3F56EA6CA2BEQ34752532-DF64B7F8-835D-46E7-98A0-B6DF2C42A51BQ34876473-D609311E-9B82-4DD1-9847-BED8E1492BB3Q34974989-9734720B-54B3-47C1-8A26-9F45DE592404Q35009536-4D171262-BD12-479C-86D0-EA5FD7D4EA24Q35020444-ABB1ABAF-73DF-4F76-9AA9-38EE0788EB36Q35170416-51BDCC2E-4448-4ECB-8FF7-3D5EB13D0958
P2860
Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing
description
2007 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2007
@ast
im Dezember 2007 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2007/12/01)
@sk
vědecký článek publikovaný v roce 2007
@cs
wetenschappelijk artikel (gepubliceerd op 2007/12/01)
@nl
наукова стаття, опублікована в грудні 2007
@uk
مقالة علمية (نشرت في ديسمبر 2007)
@ar
name
Dnmt3b promotes tumorigenesis ...... and transcriptional silencing
@ast
Dnmt3b promotes tumorigenesis ...... and transcriptional silencing
@en
Dnmt3b promotes tumorigenesis ...... and transcriptional silencing
@nl
type
label
Dnmt3b promotes tumorigenesis ...... and transcriptional silencing
@ast
Dnmt3b promotes tumorigenesis ...... and transcriptional silencing
@en
Dnmt3b promotes tumorigenesis ...... and transcriptional silencing
@nl
prefLabel
Dnmt3b promotes tumorigenesis ...... and transcriptional silencing
@ast
Dnmt3b promotes tumorigenesis ...... and transcriptional silencing
@en
Dnmt3b promotes tumorigenesis ...... and transcriptional silencing
@nl
P2093
P2860
P3181
P356
P1433
P1476
Dnmt3b promotes tumorigenesis ...... and transcriptional silencing
@en
P2093
Alex Meissner
Erika Cantu
Eveline J. Steine
Haijiang Lin
Heinz G. Linhart
Mathias Ehrich
Sumita Gokhale
Timothy He
P2860
P304
P3181
P356
10.1101/GAD.1594007
P577
2007-12-01T00:00:00Z