The SIL gene is required for mouse embryonic axial development and left-right specification
about
The human microcephaly protein STIL interacts with CPAP and is required for procentriole formationSil phosphorylation in a Pin1 binding domain affects the duration of the spindle checkpointAutosomal Recessive Primary Microcephaly (MCPH): clinical manifestations, genetic heterogeneity and mutation continuumSPC4/PACE4 regulates a TGFbeta signaling network during axis formationSpindle orientation in mammalian cerebral cortical developmentTargeted disruption in mice of a neural stem cell-maintaining, KRAB-Zn finger-encoding gene that has rapidly evolved in the human lineageThe PLK4-STIL-SAS-6 module at the core of centriole duplicationPulling on my heartstrings: mechanotransduction in cardiac development and functionDisruption of a ciliary B9 protein complex causes Meckel syndromeCentriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplicationEstablishment of vertebrate left-right asymmetryMolecular characterization of a new recombination of the SIL/TAL-1 locus in a child with T-cell acute lymphoblastic leukaemiaTargeted deletion of the ATP binding domain of left-right dynein confirms its role in specifying development of left-right asymmetriesAcentriolar mitosis activates a p53-dependent apoptosis pathway in the mouse embryoConserved requirement for EGF-CFC genes in vertebrate left-right axis formationVIP blockade leads to microcephaly in mice via disruption of Mcph1-Chk1 signalingTargeted mutagenesis of the Hira gene results in gastrulation defects and patterning abnormalities of mesoendodermal derivatives prior to early embryonic lethalityMultiple left-right asymmetry defects in Shh(-/-) mutant mice unveil a convergence of the shh and retinoic acid pathways in the control of Lefty-1A mouse chromosome 4 balancer ENU-mutagenesis screen isolates eleven lethal lines.Microcephaly models in the developing zebrafish retinal neuroepithelium point to an underlying defect in metaphase progression.Loss of centrioles causes chromosomal instability in vertebrate somatic cells.The molecular genetics of holoprosencephaly.Primary microcephaly: do all roads lead to Rome?Drosophila Ana2 is a conserved centriole duplication factorTargeting the centriolar replication factor STIL synergizes with DNA damaging agents for treatment of ovarian cancerAngelman syndrome protein UBE3A interacts with primary microcephaly protein ASPM, localizes to centrosomes and regulates chromosome segregationSmall organelle, big responsibility: the role of centrosomes in development and disease.Risk factors for heart disease associated with abnormal sidedness.Classification of left-right patterning defects in zebrafish, mice, and humans.Midline and laterality defects: left and right meet in the middle.Roles of nodal-lefty regulatory loops in embryonic patterning of vertebrates.TGF-beta superfamily signaling and left-right asymmetry.The Stil protein regulates centrosome integrity and mitosis through suppression of Chfr.Homozygous STIL mutation causes holoprosencephaly and microcephaly in two siblings.Molecular genetics of human primary microcephaly: an overview.Genomics and expression profiles of the Hedgehog and Notch signaling pathways in sea urchin developmentThe zebra fish cassiopeia mutant reveals that SIL is required for mitotic spindle organization.A novel function of the human oncogene Stil: Regulation of PC12 cell toxic susceptibility through the Shh pathwayMutations in PLK4, encoding a master regulator of centriole biogenesis, cause microcephaly, growth failure and retinopathyFunctional expression of SCL/TAL1 interrupting locus (Stil) protects retinal dopaminergic cells from neurotoxin-induced degeneration.
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P2860
The SIL gene is required for mouse embryonic axial development and left-right specification
description
1999 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հունիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Nature
@fr
artículu científicu espublizáu en 1999
@ast
scientific journal article
@en
vedecký článok (publikovaný 1999/06/17)
@sk
vědecký článek publikovaný v roce 1999
@cs
wetenschappelijk artikel (gepubliceerd op 1999/06/17)
@nl
наукова стаття, опублікована в червні 1999
@uk
научни чланак (објављен 1999/06/17)
@sr
name
The SIL gene is required for m ...... t and left-right specification
@ast
The SIL gene is required for m ...... t and left-right specification
@en
The SIL gene is required for m ...... t and left-right specification
@nl
type
label
The SIL gene is required for m ...... t and left-right specification
@ast
The SIL gene is required for m ...... t and left-right specification
@en
The SIL gene is required for m ...... t and left-right specification
@nl
prefLabel
The SIL gene is required for m ...... t and left-right specification
@ast
The SIL gene is required for m ...... t and left-right specification
@en
The SIL gene is required for m ...... t and left-right specification
@nl
P2093
P2860
P3181
P356
P1433
P1476
The SIL gene is required for m ...... t and left-right specification
@en
P2093
D. J. Good
D. W. Dorward
I. R. Kirsch
L. A. Lowe
M. R. Kuehn
S. Izraeli
V. L. Bertness
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P2888
P304
P3181
P356
10.1038/21429
P407
P577
1999-06-17T00:00:00Z
P6179
1044410750